CN101801981A - 瑟土因调节性噻唑并吡啶化合物 - Google Patents

瑟土因调节性噻唑并吡啶化合物 Download PDF

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Publication number
CN101801981A
CN101801981A CN200880103654A CN200880103654A CN101801981A CN 101801981 A CN101801981 A CN 101801981A CN 200880103654 A CN200880103654 A CN 200880103654A CN 200880103654 A CN200880103654 A CN 200880103654A CN 101801981 A CN101801981 A CN 101801981A
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CN
China
Prior art keywords
sirtuin
compound
activity
compound according
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880103654A
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English (en)
Chinese (zh)
Inventor
琼·贝米斯
杰里米·S·迪施
吴佩仪
克里斯托弗·欧尔曼
罗伯特·B·珀尼
奇·B·武
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Sirtris Pharmaceuticals Inc
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Sirtris Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of CN101801981A publication Critical patent/CN101801981A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880103654A 2007-06-20 2008-06-20 瑟土因调节性噻唑并吡啶化合物 Pending CN101801981A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93663607P 2007-06-20 2007-06-20
US60/936,636 2007-06-20
PCT/US2008/007776 WO2008156869A2 (en) 2007-06-20 2008-06-20 Sirtuin modulating thiazolopyridine compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201310744228.7A Division CN103833775A (zh) 2007-06-20 2008-06-20 瑟土因调节性化合物

Publications (1)

Publication Number Publication Date
CN101801981A true CN101801981A (zh) 2010-08-11

Family

ID=39798234

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880103654A Pending CN101801981A (zh) 2007-06-20 2008-06-20 瑟土因调节性噻唑并吡啶化合物
CN201310744228.7A Pending CN103833775A (zh) 2007-06-20 2008-06-20 瑟土因调节性化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201310744228.7A Pending CN103833775A (zh) 2007-06-20 2008-06-20 瑟土因调节性化合物

Country Status (23)

Country Link
US (2) US7893086B2 (enExample)
EP (1) EP2170905A2 (enExample)
JP (1) JP5498940B2 (enExample)
KR (1) KR20100051048A (enExample)
CN (2) CN101801981A (enExample)
AR (1) AR067107A1 (enExample)
AU (1) AU2008266749C1 (enExample)
BR (1) BRPI0813651A2 (enExample)
CA (1) CA2691733A1 (enExample)
CL (1) CL2008001822A1 (enExample)
CO (1) CO6251248A2 (enExample)
CR (1) CR11232A (enExample)
DO (1) DOP2009000284A (enExample)
EA (1) EA018922B1 (enExample)
IL (1) IL202730A0 (enExample)
MA (1) MA31506B1 (enExample)
MX (1) MX2009013977A (enExample)
NZ (1) NZ581990A (enExample)
PE (1) PE20090694A1 (enExample)
TW (1) TW200916472A (enExample)
UY (1) UY31169A1 (enExample)
WO (1) WO2008156869A2 (enExample)
ZA (1) ZA200908883B (enExample)

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CN111885914A (zh) * 2017-10-27 2020-11-03 投资健康有限责任公司 使用芴衍生物制造扩增的造血干细胞的组合物和方法
CN112292380A (zh) * 2018-02-20 2021-01-29 因赛特公司 作为用于治疗癌症的hpk1抑制剂的n-(苯基)-2-(苯基)嘧啶-4-甲酰胺衍生物及相关化合物
US11787784B2 (en) 2019-08-06 2023-10-17 Incyte Corporation Solid forms of an HPK1 inhibitor
US11866426B2 (en) 2018-08-08 2024-01-09 Incyte Corporation Benzothiazole compounds and uses thereof
US11891388B2 (en) 2016-09-09 2024-02-06 Incyte Corporation Pyrazolopyridine compounds and uses thereof

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CN107496410A (zh) * 2017-09-21 2017-12-22 上海华堇生物技术有限责任公司 洋槐黄素的药物用途
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