CN101679401B - 用于治疗肿瘤的作为met激酶抑制剂的2-氧代-3-苄基-苯并*唑-2-酮衍生物及相关化合物 - Google Patents

用于治疗肿瘤的作为met激酶抑制剂的2-氧代-3-苄基-苯并*唑-2-酮衍生物及相关化合物 Download PDF

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CN101679401B
CN101679401B CN2008800183950A CN200880018395A CN101679401B CN 101679401 B CN101679401 B CN 101679401B CN 2008800183950 A CN2008800183950 A CN 2008800183950A CN 200880018395 A CN200880018395 A CN 200880018395A CN 101679401 B CN101679401 B CN 101679401B
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CN101679401A (zh
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O·沙特
D·多施
F·施蒂贝尔
A·布劳卡特
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2008800183950A 2007-06-06 2008-05-08 用于治疗肿瘤的作为met激酶抑制剂的2-氧代-3-苄基-苯并*唑-2-酮衍生物及相关化合物 Expired - Fee Related CN101679401B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007026341.6 2007-06-06
DE102007026341A DE102007026341A1 (de) 2007-06-06 2007-06-06 Benzoxazolonderivate
PCT/EP2008/003696 WO2008148449A1 (de) 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren

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CN101679401B true CN101679401B (zh) 2012-12-12

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KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
JP2020524718A (ja) * 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ ヒトｓｔｉｎｇの複素環式小分子調節因子
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WO2020186202A1 (en) 2019-03-14 2020-09-17 Board Of Regents, The University Of Texas System Small molecule grb2 stabilizers for ras map kinase inhibition
CN115490578B (zh) * 2022-09-23 2023-12-22 江苏理工学院 一种碳同位素标记的三氯生的制备方法

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KR20100031531A (ko) 2010-03-22
IL202505A (en) 2014-11-30
US8431572B2 (en) 2013-04-30
ZA201000085B (en) 2010-09-29
AU2008258366A1 (en) 2008-12-11
CA2689554A1 (en) 2008-12-11
EP2150551B1 (de) 2013-01-16
EP2150551A1 (de) 2010-02-10
JP5662143B2 (ja) 2015-01-28
JP2010529051A (ja) 2010-08-26
US20100280030A1 (en) 2010-11-04
MX2009013077A (es) 2010-01-15
PE20090770A1 (es) 2009-06-24
BRPI0812293A2 (pt) 2014-11-25
AU2008258366B2 (en) 2013-02-21
CN101679401A (zh) 2010-03-24
US20110263596A1 (en) 2011-10-27
WO2008148449A1 (de) 2008-12-11
TW200848030A (en) 2008-12-16
ES2402540T3 (es) 2013-05-06
AR066892A1 (es) 2009-09-16
IL202505A0 (en) 2010-06-30
CA2689554C (en) 2015-12-01
US8071593B2 (en) 2011-12-06
DE102007026341A1 (de) 2008-12-11
EA200901611A1 (ru) 2010-06-30

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