AU2008258366B2 - 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumors - Google Patents

2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumors Download PDF

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Publication number
AU2008258366B2
AU2008258366B2 AU2008258366A AU2008258366A AU2008258366B2 AU 2008258366 B2 AU2008258366 B2 AU 2008258366B2 AU 2008258366 A AU2008258366 A AU 2008258366A AU 2008258366 A AU2008258366 A AU 2008258366A AU 2008258366 B2 AU2008258366 B2 AU 2008258366B2
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AU
Australia
Prior art keywords
methyl
phenyl
ylmethyl
methylpiperazin
mmol
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Ceased
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AU2008258366A
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English (en)
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AU2008258366A1 (en
Inventor
Andree Blaukat
Dieter Dorsch
Oliver Schadt
Frank Stieber
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Merck Patent GmbH
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Merck Patent GmbH
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Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2008258366A 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumors Ceased AU2008258366B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007026341.6 2007-06-06
DE102007026341A DE102007026341A1 (de) 2007-06-06 2007-06-06 Benzoxazolonderivate
PCT/EP2008/003696 WO2008148449A1 (de) 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
AU2008258366A1 AU2008258366A1 (en) 2008-12-11
AU2008258366B2 true AU2008258366B2 (en) 2013-02-21

Family

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Family Applications (1)

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AU2008258366A Ceased AU2008258366B2 (en) 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumors

Country Status (18)

Country Link
US (2) US8071593B2 (enExample)
EP (1) EP2150551B1 (enExample)
JP (1) JP5662143B2 (enExample)
KR (1) KR20100031531A (enExample)
CN (1) CN101679401B (enExample)
AR (1) AR066892A1 (enExample)
AU (1) AU2008258366B2 (enExample)
BR (1) BRPI0812293A2 (enExample)
CA (1) CA2689554C (enExample)
DE (1) DE102007026341A1 (enExample)
EA (1) EA200901611A1 (enExample)
ES (1) ES2402540T3 (enExample)
IL (1) IL202505A (enExample)
MX (1) MX2009013077A (enExample)
PE (1) PE20090770A1 (enExample)
TW (1) TW200848030A (enExample)
WO (1) WO2008148449A1 (enExample)
ZA (1) ZA201000085B (enExample)

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DE102008028905A1 (de) * 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
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JP2020524718A (ja) * 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ ヒトｓｔｉｎｇの複素環式小分子調節因子
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN115490578A (zh) * 2022-09-23 2022-12-20 江苏理工学院 一种碳同位素标记的三氯生的制备方法
CN115490578B (zh) * 2022-09-23 2023-12-22 江苏理工学院 一种碳同位素标记的三氯生的制备方法

Also Published As

Publication number Publication date
KR20100031531A (ko) 2010-03-22
IL202505A (en) 2014-11-30
US8431572B2 (en) 2013-04-30
ZA201000085B (en) 2010-09-29
AU2008258366A1 (en) 2008-12-11
CA2689554A1 (en) 2008-12-11
EP2150551B1 (de) 2013-01-16
EP2150551A1 (de) 2010-02-10
JP5662143B2 (ja) 2015-01-28
JP2010529051A (ja) 2010-08-26
US20100280030A1 (en) 2010-11-04
MX2009013077A (es) 2010-01-15
PE20090770A1 (es) 2009-06-24
BRPI0812293A2 (pt) 2014-11-25
CN101679401A (zh) 2010-03-24
US20110263596A1 (en) 2011-10-27
WO2008148449A1 (de) 2008-12-11
CN101679401B (zh) 2012-12-12
TW200848030A (en) 2008-12-16
ES2402540T3 (es) 2013-05-06
AR066892A1 (es) 2009-09-16
IL202505A0 (en) 2010-06-30
CA2689554C (en) 2015-12-01
US8071593B2 (en) 2011-12-06
DE102007026341A1 (de) 2008-12-11
EA200901611A1 (ru) 2010-06-30

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