AR066892A1 - Derivados de benzoxazolona, proceso, medicamento, uso para tratar tumores y kit - Google Patents
Derivados de benzoxazolona, proceso, medicamento, uso para tratar tumores y kitInfo
- Publication number
- AR066892A1 AR066892A1 ARP080102415A ARP080102415A AR066892A1 AR 066892 A1 AR066892 A1 AR 066892A1 AR P080102415 A ARP080102415 A AR P080102415A AR P080102415 A ARP080102415 A AR P080102415A AR 066892 A1 AR066892 A1 AR 066892A1
- Authority
- AR
- Argentina
- Prior art keywords
- mnha
- mnh2
- hal
- mnaa
- conh
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007026341A DE102007026341A1 (de) | 2007-06-06 | 2007-06-06 | Benzoxazolonderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066892A1 true AR066892A1 (es) | 2009-09-16 |
Family
ID=39739806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102415A AR066892A1 (es) | 2007-06-06 | 2008-06-06 | Derivados de benzoxazolona, proceso, medicamento, uso para tratar tumores y kit |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8071593B2 (enExample) |
| EP (1) | EP2150551B1 (enExample) |
| JP (1) | JP5662143B2 (enExample) |
| KR (1) | KR20100031531A (enExample) |
| CN (1) | CN101679401B (enExample) |
| AR (1) | AR066892A1 (enExample) |
| AU (1) | AU2008258366B2 (enExample) |
| BR (1) | BRPI0812293A2 (enExample) |
| CA (1) | CA2689554C (enExample) |
| DE (1) | DE102007026341A1 (enExample) |
| EA (1) | EA200901611A1 (enExample) |
| ES (1) | ES2402540T3 (enExample) |
| IL (1) | IL202505A (enExample) |
| MX (1) | MX2009013077A (enExample) |
| PE (1) | PE20090770A1 (enExample) |
| TW (1) | TW200848030A (enExample) |
| WO (1) | WO2008148449A1 (enExample) |
| ZA (1) | ZA201000085B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| CA2724715A1 (en) | 2008-05-22 | 2009-11-26 | Amgen Inc. | Heterocycles as protein kinase inhibitors |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| EA201170349A1 (ru) * | 2008-08-18 | 2011-08-30 | Йейл Юниверсити | Модуляторы mif |
| US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| EA019320B1 (ru) | 2008-12-22 | 2014-02-28 | Мерк Патент Гмбх | Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения |
| DE102009003975A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
| WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| JP2014518267A (ja) | 2011-06-27 | 2014-07-28 | 杏林製薬株式会社 | 細菌感染症の治療のための架橋二環式化合物 |
| CN103242345B (zh) * | 2012-09-14 | 2015-03-11 | 日出实业集团有限公司 | 甲基吡啶磷中间体6-氯噁唑[4,5-b]吡啶-2(3H)酮的合成方法 |
| AR095883A1 (es) | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
| US9549988B2 (en) | 2013-06-09 | 2017-01-24 | RJS Biologics | Pharmaceutical compounds targeted by MIF affinity-tethered moieties |
| EP3229836B1 (en) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| EP3642197A1 (en) * | 2017-06-22 | 2020-04-29 | Curadev Pharma Limited | Heterocyclic small molecule modulators of human sting |
| CN111465602B (zh) | 2017-10-17 | 2023-05-23 | 帕劳制药有限公司 | 4-氨基嘧啶化合物的合成 |
| EP3937919A4 (en) | 2019-03-14 | 2023-04-12 | Board of Regents, The University of Texas System | SMALL MOLECULES GRB2 STABILIZER FOR INHIBITION OF RAS-MAP KINASE |
| CN115490578B (zh) * | 2022-09-23 | 2023-12-22 | 江苏理工学院 | 一种碳同位素标记的三氯生的制备方法 |
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| JPS421467B1 (enExample) * | 1963-11-28 | 1967-01-24 | ||
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| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
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| KR100883731B1 (ko) | 2001-06-22 | 2009-02-12 | 기린 파마 가부시끼가이샤 | 간세포 증식 인자 수용체 자기 인산화를 저해하는 퀴놀린유도체 및 퀴나졸린 유도체 및 이들을 함유하는 의약 조성물 |
| MXPA04003668A (es) | 2001-10-31 | 2004-07-22 | Merck Patent Gmbh | Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos. |
| CA2470214A1 (en) * | 2001-12-13 | 2003-06-26 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
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| UA77526C2 (en) | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
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| EP1773826A4 (en) | 2004-07-02 | 2009-06-03 | Exelixis Inc | MODULATORS OF C-MET AND THEIR METHOD OF USE |
| DE102004036581A1 (de) | 2004-07-28 | 2006-03-23 | Robert Bosch Gmbh | Verfahren zum Betreiben eines Hybridantriebs und Vorrichtung zur Durchführung des Verfahrens |
| TW200612918A (en) | 2004-07-29 | 2006-05-01 | Threshold Pharmaceuticals Inc | Lonidamine analogs |
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| CH697191A5 (de) | 2004-07-29 | 2008-06-25 | Biospectra Ag | Mehrfach-Bioreaktorvorrichtung. |
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| EP1621785A1 (en) | 2004-07-30 | 2006-02-01 | Mecos Traxler AG | Method and apparatus for controlling a magnetic bearing device |
| HRP20110116T1 (hr) | 2004-08-26 | 2011-03-31 | Pfizer Inc. | Pirazolom supstituirani heteroarilni spojevi kao inhibitori proteinskih kinaza |
| DE102005038537A1 (de) | 2005-08-16 | 2007-02-22 | Merck Patent Gmbh | 1-Acyldihydropyrazolderivate |
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| DE102005055355A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
| DE102005055354A1 (de) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| EP1963329B1 (en) | 2005-11-30 | 2013-01-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
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| BRPI0620292B1 (pt) | 2005-12-21 | 2021-08-24 | Janssen Pharmaceutica N. V. | Compostos de triazolopiridazinas como moduladores da cinase, composição, uso, combinação e processo de preparo do referido composto |
| WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| NL2000613C2 (nl) | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
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| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| CN101827595B (zh) | 2007-10-16 | 2013-07-24 | 诺瓦提斯公司 | 作为神经肽y2受体调节剂的取代的哌嗪和哌啶类 |
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| JP5769970B2 (ja) | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
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| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
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| US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
| CN101538245B (zh) | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
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| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| WO2010010150A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| JP5253143B2 (ja) | 2008-12-26 | 2013-07-31 | キヤノン株式会社 | 情報処理装置、情報処理装置の制御方法、及びプログラム |
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-
2007
- 2007-06-06 DE DE102007026341A patent/DE102007026341A1/de not_active Withdrawn
-
2008
- 2008-05-08 US US12/663,206 patent/US8071593B2/en not_active Expired - Fee Related
- 2008-05-08 AU AU2008258366A patent/AU2008258366B2/en not_active Ceased
- 2008-05-08 BR BRPI0812293-8A2A patent/BRPI0812293A2/pt not_active IP Right Cessation
- 2008-05-08 ES ES08749391T patent/ES2402540T3/es active Active
- 2008-05-08 MX MX2009013077A patent/MX2009013077A/es not_active Application Discontinuation
- 2008-05-08 KR KR1020107000014A patent/KR20100031531A/ko not_active Withdrawn
- 2008-05-08 CA CA2689554A patent/CA2689554C/en active Active
- 2008-05-08 EA EA200901611A patent/EA200901611A1/ru unknown
- 2008-05-08 JP JP2010510658A patent/JP5662143B2/ja not_active Expired - Fee Related
- 2008-05-08 EP EP08749391A patent/EP2150551B1/de not_active Not-in-force
- 2008-05-08 CN CN2008800183950A patent/CN101679401B/zh not_active Expired - Fee Related
- 2008-05-08 WO PCT/EP2008/003696 patent/WO2008148449A1/de not_active Ceased
- 2008-06-05 PE PE2008000958A patent/PE20090770A1/es not_active Application Discontinuation
- 2008-06-06 TW TW097121279A patent/TW200848030A/zh unknown
- 2008-06-06 AR ARP080102415A patent/AR066892A1/es unknown
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2009
- 2009-12-03 IL IL202505A patent/IL202505A/en active IP Right Grant
-
2010
- 2010-01-05 ZA ZA201000085A patent/ZA201000085B/xx unknown
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2011
- 2011-07-06 US US13/177,261 patent/US8431572B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201000085B (en) | 2010-09-29 |
| IL202505A0 (en) | 2010-06-30 |
| WO2008148449A1 (de) | 2008-12-11 |
| IL202505A (en) | 2014-11-30 |
| CN101679401B (zh) | 2012-12-12 |
| US20110263596A1 (en) | 2011-10-27 |
| AU2008258366B2 (en) | 2013-02-21 |
| TW200848030A (en) | 2008-12-16 |
| EP2150551A1 (de) | 2010-02-10 |
| EA200901611A1 (ru) | 2010-06-30 |
| CA2689554A1 (en) | 2008-12-11 |
| KR20100031531A (ko) | 2010-03-22 |
| ES2402540T3 (es) | 2013-05-06 |
| DE102007026341A1 (de) | 2008-12-11 |
| PE20090770A1 (es) | 2009-06-24 |
| CN101679401A (zh) | 2010-03-24 |
| JP5662143B2 (ja) | 2015-01-28 |
| JP2010529051A (ja) | 2010-08-26 |
| EP2150551B1 (de) | 2013-01-16 |
| MX2009013077A (es) | 2010-01-15 |
| AU2008258366A1 (en) | 2008-12-11 |
| US8431572B2 (en) | 2013-04-30 |
| CA2689554C (en) | 2015-12-01 |
| US8071593B2 (en) | 2011-12-06 |
| BRPI0812293A2 (pt) | 2014-11-25 |
| US20100280030A1 (en) | 2010-11-04 |
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