AR072148A1 - Derivados de quinoxalindiona - Google Patents
Derivados de quinoxalindionaInfo
- Publication number
- AR072148A1 AR072148A1 ARP090102166A ARP090102166A AR072148A1 AR 072148 A1 AR072148 A1 AR 072148A1 AR P090102166 A ARP090102166 A AR P090102166A AR P090102166 A ARP090102166 A AR P090102166A AR 072148 A1 AR072148 A1 AR 072148A1
- Authority
- AR
- Argentina
- Prior art keywords
- denotes
- coa
- hal
- mono
- nha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente se refiere a compuestos de la formula (1) en la que X, Y, Z denotan cada uno, de modo independiente entre s¡, N o CR4, excluyendo los compuestos en los que X=Z=N, R1 denota H, A, COA, COOR5, CONR6R7, Ar o Het, R2, R3 denotan cada uno, de modo independiente entre s¡, H o A', R4 denota H, A, OH, OA, Hal, NH2, NHA, NA2, NO2, COA, COOR5, CONR6R7, CN, Ar o Het, R5 denota H o A', R6, R7 denotan cada uno, de modo independiente entre s¡, H, A, Ar o Het1, R6 y R7 tambien denotan juntos (CH2)m; Ar denota fenilo, naftilo o bifenilo, cada uno de los cuales no est sustituido o est mono-, di-, ri-, tetra- o pentasustituido con A, Hal, OA, OH, CHO, COA, NH2, NHA, NA2, NO2, COOA, COOH, CONH2, CONA, CONA2, SO2A, CN, C(=NH)NH2 y/o C(=NH)NHOH, Het denota un heterociclo mono- o bic¡clico saturado, insaturado o arom tico que tiene de 1 a 4 tomos de N, O y/o S, que puede estar mono-, di- o trisustituido con Hal, A, OA, OH, CHO, COA, COOH, COOA, CN, NO2, NH2, NHA, NA2, CONH2, CONHA, CONA2 y/u =O, Het1 denota un heterociclo mono- o bic¡clico insaturado o arom tico que tiene de 1 a 4 tomos de N, O y/o S, que puede estar mono-, di- o trisustituido con Hal, A, OA, OH, CHO, COA, COOH, COOA, CN, NO2, NH2, NHA, NA2, CONH2, CONHA y/o CONA2, A denota alquilo no ramificado o ramificado C1-10, en donde uno o dos grupos no adyacentes CH y/o CH2 pueden estar reemplazados por O y/o NH y/o adem s, 1-7 tomos de H pueden estar reemplazados por OH, F y/o Cl, o denota cicloalquilo C3-7, A' denota alquilo no ramificado o ramificado C1-6, en donde 1-7 tomos de H pueden estar reemplazados por F y/o Cl, Hal denota F, Cl, Br o I, m 2, 3, 4, 5 o 6, y sus sales y estereoisomeros farmaceuticamente aceptables, incluyendo sus mezclas en todas las proporciones. Incluyendo sus composiciones farmaceuticas y su uso en el tratamiento y/o la prevencion de diabetes, s¡ndrome metabolico, obesidad, c ncer, inflamacion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290564 | 2008-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072148A1 true AR072148A1 (es) | 2010-08-11 |
Family
ID=40823394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102166A AR072148A1 (es) | 2008-06-16 | 2009-06-16 | Derivados de quinoxalindiona |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8329698B2 (es) |
| EP (1) | EP2285786B1 (es) |
| JP (1) | JP5596676B2 (es) |
| KR (1) | KR101641391B1 (es) |
| CN (1) | CN102066342B (es) |
| AR (1) | AR072148A1 (es) |
| AU (1) | AU2009259754B2 (es) |
| BR (1) | BRPI0915064B8 (es) |
| CA (1) | CA2728018C (es) |
| CO (1) | CO6321252A2 (es) |
| CY (1) | CY1114737T1 (es) |
| DK (1) | DK2285786T3 (es) |
| EA (1) | EA020236B1 (es) |
| EC (1) | ECSP11010760A (es) |
| ES (1) | ES2436195T3 (es) |
| HK (1) | HK1157784A1 (es) |
| HR (1) | HRP20131069T1 (es) |
| IL (1) | IL209421A (es) |
| MX (1) | MX2010013577A (es) |
| MY (1) | MY155695A (es) |
| NZ (1) | NZ590503A (es) |
| PL (1) | PL2285786T3 (es) |
| PT (1) | PT2285786E (es) |
| SI (1) | SI2285786T1 (es) |
| WO (1) | WO2009152909A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| RS61664B1 (sr) | 2012-04-24 | 2021-04-29 | Vertex Pharma | Inhibitori dna-pk |
| RS58374B1 (sr) | 2013-03-12 | 2019-03-29 | Vertex Pharma | Inhibitori dnk-pk |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ａｍｐｋを活性化させるインダゾール化合物 |
| CN103435561B (zh) * | 2013-08-19 | 2016-08-10 | 上海交通大学 | 一种新型d-氨基酸氧化酶抑制剂及其制备和应用 |
| EP3057953B1 (en) | 2013-10-17 | 2018-08-15 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
| TW201815418A (zh) | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
| US20220152117A1 (en) * | 2019-03-18 | 2022-05-19 | University Of Washington | Methods of promoting cellular maturation with ampk activators |
| CN110642798B (zh) * | 2019-11-10 | 2020-07-24 | 湖南科技学院 | 一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法 |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| UY39222A (es) | 2020-05-19 | 2021-11-30 | Kallyope Inc | Activadores de la ampk |
| EP4172162A4 (en) | 2020-06-26 | 2024-08-07 | Kallyope Inc | AMPK ACTIVATORS |
| EP4221700A1 (en) | 2020-09-30 | 2023-08-09 | Bioverativ Therapeutics Inc. | Ampk activators and methods of use thereof |
| US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
| WO2022114812A1 (ko) * | 2020-11-26 | 2022-06-02 | 주식회사 엘지화학 | 다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
| NZ336971A (en) | 1997-02-18 | 2000-10-27 | American Home Prod | 5-Aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones useful as dopamine agonists |
| WO2002096422A2 (en) | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Combination of a dopamine d2-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways |
| US20050148586A1 (en) * | 2004-01-06 | 2005-07-07 | Beavers Mary P. | Quinoxalinones |
| MY139645A (en) * | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| JP2009537520A (ja) * | 2006-05-15 | 2009-10-29 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｆｇｆ受容体キナーゼ阻害剤のための組成物および方法 |
| FR2903695B1 (fr) * | 2006-07-13 | 2008-10-24 | Merck Sante Soc Par Actions Si | Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2009
- 2009-05-19 ES ES09765489T patent/ES2436195T3/es active Active
- 2009-05-19 NZ NZ590503A patent/NZ590503A/xx unknown
- 2009-05-19 BR BRPI0915064A patent/BRPI0915064B8/pt active IP Right Grant
- 2009-05-19 EP EP09765489.1A patent/EP2285786B1/en active Active
- 2009-05-19 WO PCT/EP2009/003538 patent/WO2009152909A1/en active Application Filing
- 2009-05-19 DK DK09765489.1T patent/DK2285786T3/da active
- 2009-05-19 AU AU2009259754A patent/AU2009259754B2/en active Active
- 2009-05-19 CA CA2728018A patent/CA2728018C/en active Active
- 2009-05-19 PL PL09765489T patent/PL2285786T3/pl unknown
- 2009-05-19 SI SI200930812T patent/SI2285786T1/sl unknown
- 2009-05-19 US US12/997,641 patent/US8329698B2/en active Active
- 2009-05-19 MY MYPI2010005917A patent/MY155695A/en unknown
- 2009-05-19 KR KR1020117000992A patent/KR101641391B1/ko active IP Right Grant
- 2009-05-19 MX MX2010013577A patent/MX2010013577A/es active IP Right Grant
- 2009-05-19 PT PT97654891T patent/PT2285786E/pt unknown
- 2009-05-19 JP JP2011513895A patent/JP5596676B2/ja active Active
- 2009-05-19 EA EA201100007A patent/EA020236B1/ru not_active IP Right Cessation
- 2009-05-19 CN CN2009801227397A patent/CN102066342B/zh active Active
- 2009-06-16 AR ARP090102166A patent/AR072148A1/es active IP Right Grant
-
2010
- 2010-11-18 IL IL209421A patent/IL209421A/en active IP Right Grant
- 2010-12-14 CO CO10156748A patent/CO6321252A2/es active IP Right Grant
-
2011
- 2011-01-14 EC EC2011010760A patent/ECSP11010760A/es unknown
- 2011-11-16 HK HK11112373.9A patent/HK1157784A1/xx unknown
-
2012
- 2012-08-24 US US13/593,722 patent/US8674097B2/en active Active
-
2013
- 2013-11-08 HR HRP20131069AT patent/HRP20131069T1/hr unknown
- 2013-12-27 CY CY20131101166T patent/CY1114737T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal | ||
| FG | Grant, registration |