CN101568529A - 作为cdk抑制剂、用于治疗癌症、炎症和病毒感染的杂芳基-杂芳基化合物 - Google Patents

作为cdk抑制剂、用于治疗癌症、炎症和病毒感染的杂芳基-杂芳基化合物 Download PDF

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Publication number
CN101568529A
CN101568529A CNA2007800476340A CN200780047634A CN101568529A CN 101568529 A CN101568529 A CN 101568529A CN A2007800476340 A CNA2007800476340 A CN A2007800476340A CN 200780047634 A CN200780047634 A CN 200780047634A CN 101568529 A CN101568529 A CN 101568529A
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replacement
unsubstituted
alkyl
compound
hydrogen
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R·E·J·贝克威思
D·T·柯蒂斯
E·哈林顿
J·H-H·欣里希斯
J·A·塔拉里科
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Novartis AG
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
CNA2007800476340A 2006-12-22 2007-12-20 作为cdk抑制剂、用于治疗癌症、炎症和病毒感染的杂芳基-杂芳基化合物 Pending CN101568529A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87147106P 2006-12-22 2006-12-22
US60/871,471 2006-12-22

Publications (1)

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CN101568529A true CN101568529A (zh) 2009-10-28

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US (1) US20100048597A1 (https=)
EP (1) EP2094682A2 (https=)
JP (1) JP2010514689A (https=)
KR (1) KR20090091306A (https=)
CN (1) CN101568529A (https=)
AU (1) AU2007336933A1 (https=)
BR (1) BRPI0720635A2 (https=)
CA (1) CA2672518A1 (https=)
EA (1) EA200900799A1 (https=)
MX (1) MX2009006536A (https=)
WO (1) WO2008079933A2 (https=)

Cited By (19)

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CN102712621A (zh) * 2009-12-31 2012-10-03 诺瓦提斯公司 吡嗪衍生物及其在治疗神经学障碍中的用途
CN103298787A (zh) * 2010-11-17 2013-09-11 诺瓦提斯公司 3-(氨基芳基)-吡啶化合物
CN103476759A (zh) * 2011-04-19 2013-12-25 拜耳知识产权有限责任公司 取代的4-芳基-n-苯基-1,3,5-三嗪-2-胺
CN103702979A (zh) * 2011-05-24 2014-04-02 拜耳知识产权有限责任公司 含亚磺酰亚胺基团的4-芳基-n-苯基-1,3,5-三嗪-2-胺
CN103930399A (zh) * 2011-09-16 2014-07-16 拜耳知识产权有限责任公司 包含亚氨基亚磺酰基的二取代的5-氟嘧啶衍生物
CN104507941A (zh) * 2012-07-31 2015-04-08 百时美施贵宝公司 芳基内酰胺激酶抑制剂
CN104619686A (zh) * 2012-08-23 2015-05-13 霍夫曼-拉罗奇有限公司 用于治疗癌症的新的苯基-吡啶/吡嗪酰胺
CN105916848A (zh) * 2013-12-31 2016-08-31 山东轩竹医药科技有限公司 激酶抑制剂及其用途
CN106188029A (zh) * 2015-05-05 2016-12-07 山东轩竹医药科技有限公司 二并环类间变性淋巴瘤激酶抑制剂
CN106699785A (zh) * 2015-07-13 2017-05-24 南开大学 作为CDK4/6抑制剂的2-(N-氧化吡啶-2基氨基)-吡啶并[2,3-d]嘧啶-7-酮类化合物
US9949976B2 (en) 2013-12-31 2018-04-24 Xuanzhu Pharma Co., Ltd. Kinase inhibitor and use thereof
CN109678962A (zh) * 2019-01-22 2019-04-26 山西农业大学 一种Cdk5纳米抗体和筛选方法
CN109836385A (zh) * 2019-04-04 2019-06-04 上海翰森生物医药科技有限公司 四氢喹啉类n-氧化衍生物及其制备方法和应用
CN109985241A (zh) * 2017-12-29 2019-07-09 广州威溶特医药科技有限公司 Cdk抑制剂和溶瘤病毒在制备抗肿瘤药物的应用
CN110041253A (zh) * 2018-01-17 2019-07-23 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
CN110511211A (zh) * 2019-08-30 2019-11-29 武汉工程大学 一种吲唑哌啶嘧啶类化合物的应用
WO2022028556A1 (zh) * 2020-08-07 2022-02-10 南京药石科技股份有限公司 Cdk9抑制剂及其用途
WO2024008083A1 (zh) * 2022-07-04 2024-01-11 浙江同源康医药股份有限公司 用作cdk7激酶抑制剂的化合物及其应用
CN119841771A (zh) * 2025-01-08 2025-04-18 华中农业大学 一种猪链球菌丝氨酸蛋白激酶抑制剂的筛选方法及其应用

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HK1209414A1 (en) 2012-10-18 2016-04-01 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
CN105102434A (zh) 2012-10-18 2015-11-25 拜耳药业股份公司 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺
JP6277196B2 (ja) 2012-10-18 2018-02-07 バイエル ファーマ アクチエンゲゼルシャフト スルホン基を含んでいるｎ−（ピリジン−２−イル）ピリミジン−４−アミン誘導体
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KR20220143164A (ko) 2012-11-21 2022-10-24 피티씨 테라퓨틱스, 인크. 치환된 리버스 피리미딘 ｂｍｉ-1 저해제
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
DK2968290T3 (da) 2013-03-15 2019-11-25 G1 Therapeutics Inc Transient beskyttelse af normale celler under kemoterapi
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