CN1014791B - 生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法 - Google Patents

生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法

Info

Publication number
CN1014791B
CN1014791B CN85104463A CN85104463A CN1014791B CN 1014791 B CN1014791 B CN 1014791B CN 85104463 A CN85104463 A CN 85104463A CN 85104463 A CN85104463 A CN 85104463A CN 1014791 B CN1014791 B CN 1014791B
Authority
CN
China
Prior art keywords
trityl
glyceryl
general formula
acid
phosphocholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN85104463A
Other languages
English (en)
Chinese (zh)
Other versions
CN85104463A (zh
Inventor
帕尔陶夫
赫尔梅特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Patheon Austria GmbH and Co KG
Original Assignee
Chemie Linz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz AG filed Critical Chemie Linz AG
Priority to CN85104463A priority Critical patent/CN1014791B/zh
Publication of CN85104463A publication Critical patent/CN85104463A/zh
Publication of CN1014791B publication Critical patent/CN1014791B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Resins (AREA)
  • Hydrogenated Pyridines (AREA)
CN85104463A 1984-05-15 1985-06-11 生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法 Expired CN1014791B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN85104463A CN1014791B (zh) 1984-05-15 1985-06-11 生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0159084A AT383130B (de) 1984-05-15 1984-05-15 Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
CN85104463A CN1014791B (zh) 1984-05-15 1985-06-11 生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法

Publications (2)

Publication Number Publication Date
CN85104463A CN85104463A (zh) 1986-12-10
CN1014791B true CN1014791B (zh) 1991-11-20

Family

ID=3516711

Family Applications (1)

Application Number Title Priority Date Filing Date
CN85104463A Expired CN1014791B (zh) 1984-05-15 1985-06-11 生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法

Country Status (24)

Country Link
US (2) US4622180A (enExample)
EP (1) EP0161519B1 (enExample)
JP (1) JPS60252490A (enExample)
KR (1) KR920009556B1 (enExample)
CN (1) CN1014791B (enExample)
AT (2) AT383130B (enExample)
AU (1) AU565316B2 (enExample)
BR (1) BR8502293A (enExample)
CA (1) CA1244462A (enExample)
DD (2) DD245668A1 (enExample)
DE (1) DE3563533D1 (enExample)
DK (2) DK167441C (enExample)
ES (2) ES543147A0 (enExample)
FI (1) FI77663C (enExample)
HU (2) HU199486B (enExample)
IE (1) IE58511B1 (enExample)
IL (1) IL75133A (enExample)
NO (1) NO163100C (enExample)
NZ (1) NZ212067A (enExample)
PH (2) PH21831A (enExample)
SU (2) SU1422999A3 (enExample)
TR (1) TR22204A (enExample)
YU (2) YU45720B (enExample)
ZA (1) ZA853697B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT383130B (de) * 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
DE3638687A1 (de) * 1986-11-13 1988-05-19 Lentia Gmbh Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3-phosphocholinen
AT388165B (de) * 1986-12-10 1989-05-10 Chemie Linz Ag Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3- phosphocholinen
JP2657486B2 (ja) * 1987-02-20 1997-09-24 花王株式会社 洗浄剤組成物
US5144045A (en) * 1990-11-13 1992-09-01 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
DE4233044A1 (de) * 1992-10-01 1994-04-07 Asta Medica Ag Phospholipidderivate, die höhere Elemente der V. Hauptgruppe enthalten
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
CH698539A8 (de) * 2003-08-18 2009-10-15 Btg Int Ltd Verbindungen mit ungesättigten Fettsäureresten zur Herstellung von Medikamenten zur Behandlung von multipler Sklerose.
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
CN101039680B (zh) * 2004-07-09 2011-08-03 脉管生物生长有限公司 制备氧化磷脂的改进方法
GB0425932D0 (en) * 2004-11-25 2004-12-29 Btg Int Ltd Structured phospholipids
GB0504362D0 (en) 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
RU2382765C1 (ru) * 2008-10-24 2010-02-27 Государственное образовательное учреждение высшего профессионального образования "Московская государственная академия тонкой химической технологии имени М.В. Ломоносова" Rac-N,N-ДИМЕТИЛ-N-[2-(5-N',N'- ДИМЕТИЛАМИНОНАФТАЛЕН-1-СУЛЬФОНИЛОКСИ)ЭТИЛ]-N- {4-[(2-МЕТОКСИ-3-ОКТАДЕЦИЛОКСИ)ПРОП-1-ИЛОКСИКАРБОНИЛ]БУТИЛ} АММОНИЙИОДИД
EP2826369A3 (en) * 2008-11-06 2015-03-18 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
CN104017019A (zh) * 2014-06-12 2014-09-03 东南大学 一种氮芥-甘油磷脂酰胆碱化合物的合成方法
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CA2968790A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis
CZ308596B6 (cs) * 2017-04-03 2020-12-23 Ústav molekulární genetiky AV ČR, v. v. i. Deriváty fosfolipidů a jejich použití jako léčiva
PL232298B1 (pl) * 2017-06-30 2019-06-28 Univ Przyrodniczy We Wroclawiu Sposób otrzymywania fosfatydylocholiny zawierającej ibuprofen w pozycji sn-1
PL232663B1 (pl) * 2017-06-30 2019-07-31 Univ Przyrodniczy We Wroclawiu Fosfatydylocholiny oraz sposób ich otrzymywania

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2820893C2 (de) * 1978-05-12 1986-02-20 A. Nattermann & Cie GmbH, 5000 Köln Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
IT1123187B (it) * 1979-09-17 1986-04-30 Lpb Ist Farm Processo per la preparazione di l-alfa-glicerilfosforilcolina
DE3130867A1 (de) * 1981-08-04 1983-02-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Zwischenprodukte zur herstellung von glycerinderivaten
AT383130B (de) * 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin

Also Published As

Publication number Publication date
NO163100C (no) 1990-04-04
KR850008677A (ko) 1985-12-21
IL75133A (en) 1988-12-30
FI77663C (fi) 1989-04-10
ATE35416T1 (de) 1988-07-15
DD245668A1 (de) 1987-05-13
BR8502293A (pt) 1986-01-21
AU565316B2 (en) 1987-09-10
DK167441C (da) 1994-04-18
FI77663B (fi) 1988-12-30
YU81685A (en) 1987-10-31
PH21831A (en) 1988-03-17
ES8603900A1 (es) 1986-01-01
EP0161519A2 (de) 1985-11-21
ZA853697B (en) 1986-01-29
YU81585A (en) 1987-10-31
JPS60252490A (ja) 1985-12-13
FI851781L (fi) 1985-11-16
ATA159084A (de) 1986-10-15
AU4244885A (en) 1985-11-21
ES8603899A1 (es) 1986-01-01
CA1244462A (en) 1988-11-08
DK98192D0 (da) 1992-08-03
CN85104463A (zh) 1986-12-10
US4717512A (en) 1988-01-05
YU45720B (sh) 1992-07-20
DD233130A1 (de) 1986-02-19
EP0161519B1 (de) 1988-06-29
CA1251462C (enExample) 1989-03-21
HU203555B (en) 1991-08-28
DK212185D0 (da) 1985-05-14
TR22204A (tr) 1986-09-24
ES543147A0 (es) 1986-01-01
IL75133A0 (en) 1985-09-29
DK167441B (da) 1993-11-01
FI851781A0 (fi) 1985-05-07
EP0161519A3 (en) 1986-02-12
YU45719B (sh) 1992-07-20
NZ212067A (en) 1988-10-28
DK98192A (da) 1992-08-03
DE3563533D1 (en) 1988-08-04
NO851928L (no) 1985-11-18
NO163100B (no) 1989-12-27
DK212185A (da) 1985-11-16
HUT39454A (en) 1986-09-29
PH23978A (en) 1990-02-09
KR920009556B1 (ko) 1992-10-19
JPH0482157B2 (enExample) 1992-12-25
IE851136L (en) 1985-11-15
ES543146A0 (es) 1986-01-01
US4622180A (en) 1986-11-11
IE58511B1 (en) 1993-10-06
SU1400511A3 (ru) 1988-05-30
HU199486B (en) 1990-02-28
SU1422999A3 (ru) 1988-09-07
AT383130B (de) 1987-05-25

Similar Documents

Publication Publication Date Title
CN1014791B (zh) 生产各自带有不同取代基的磷脂酰胆碱和磷脂酰乙醇胺的方法
CN1414969A (zh) 氢化硅烷化反应的催化剂
CN1052483C (zh) 六氮杂异纤锌矿型结构烷烃衍生物及其制备方法
CN1102829A (zh) 紫杉酚、紫杉酚类似物及其中间体的合成及它的组合物
CN1095070A (zh) 制备n4-酰基-5′-脱氧-5-氟胞苷衍生物的新方法
CN1286818C (zh) 制备三唑啉硫酮衍生物的方法
CN1198805C (zh) 制备光学活性的半酯的方法
CN1240380C (zh) 吲哚并吡咯并咔唑的相转移催化苷化方法
CN1239493C (zh) 3,6－二烷基－5,6－二氢－4－羟基－吡喃－2－酮的合成方法
CN1211387C (zh) 化学发光的1,2－二氧丁环
CN1249038C (zh) 芳基醚的制备方法
CN1339024A (zh) 生产鎓盐衍生物的方法、和新的鎓盐衍生物
CN100344647C (zh) 磷酸化肽的标记方法及选择吸附方法，使用于该方法的配位化合物、该配位化合物的制造方法及该配位化合物的原料化合物
CN1202899A (zh) 可聚磷酸二酯的合成
CN1097593C (zh) 制备六硝基六氮杂异纤锌矿型结构烷烃的方法
CN1168713C (zh) 制备鼻病毒蛋白酶抑制剂的合成路线以及关键的中间体
CN1028023C (zh) 戊二酸衍生物的制备
CN1026323C (zh) 新的磺酰苯基-β-D-硫代木糖苷的制备方法
CN1098087A (zh) 5-甲酰戊酸酯的制备方法
EP1437357B1 (en) Process for production of alkoxysilane-based compound
CN1337938A (zh) 用于制备手性氨基酸的新方法
WO2020142281A1 (en) Method of preparing functional organosilanol compounds
CN88100764A (zh) 4-乙酰氧基-3-羟乙基氮杂环丁-2-酮衍生物的制备方法
CN1226251A (zh) 含亚烷基二醇基团的叔膦
CN85104009A (zh) 制备咪唑衍生物的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C13 Decision
GR02 Examined patent application
C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Applicant after: Longde Nai hAFS Come pharmaceutical Ltd.

Applicant before: Chemie Linz Aktiengesellshaft

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: CHEMIE LINZ AG TO: HAFSTROM LUND NETCOM PHARMACEUTICAL CO., LTD.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee