ES8603899A1 - Procedimiento para la obtencion de derivados trifenilmetili-cos de la snglicero-3-fosfocolina y sn-glicero-3-fosfoetano-lamina - Google Patents

Procedimiento para la obtencion de derivados trifenilmetili-cos de la snglicero-3-fosfocolina y sn-glicero-3-fosfoetano-lamina

Info

Publication number
ES8603899A1
ES8603899A1 ES543146A ES543146A ES8603899A1 ES 8603899 A1 ES8603899 A1 ES 8603899A1 ES 543146 A ES543146 A ES 543146A ES 543146 A ES543146 A ES 543146A ES 8603899 A1 ES8603899 A1 ES 8603899A1
Authority
ES
Spain
Prior art keywords
glycerophosphoethanol
glycerophosphocholine
amine
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543146A
Other languages
English (en)
Other versions
ES543146A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Patheon Austria GmbH and Co KG
Original Assignee
Chemie Linz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz AG filed Critical Chemie Linz AG
Publication of ES543146A0 publication Critical patent/ES543146A0/es
Publication of ES8603899A1 publication Critical patent/ES8603899A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epoxy Resins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS TRIFENILMETALICOS DE LA SN-GLICERO-3-FOSFOCOLINA Y SN-GLICERO-3-FOSFOETANOLAMINA, EN FORMA DE ENANTIOMEROS PUROS, DE FORMULA (I), EN LA QUE T, R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE SN-GLICERO-3-FOSFOCOLINA O SN-GLICERO-3-FOSFO(N-TRIFENILMETIL)-ETANOLAMINA DE FORMULA (II) CON UN DERIVADO DE TRIFENILMETILO REACTIVO, TAL COMO UN COMPUESTO DE FORMULA T-X, EN LAS QUE T1, R1, R2 Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y X ES CLORO, BROMO O YODO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO O MEZCLA DE DISOLVENTES A TEMPERATURA ENTRE LA AMBIENTE Y LA DE EBULLICION DEL DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA SINTESIS DE 1,2-DIACIL-SIN-GLICERO-3-FOSFOCOLINA Y 1,2-DIACIL-SN-GLICERO-3- FOSFOETANOLAMINAS.
ES543146A 1984-05-15 1985-05-14 Procedimiento para la obtencion de derivados trifenilmetili-cos de la snglicero-3-fosfocolina y sn-glicero-3-fosfoetano-lamina Expired ES8603899A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0159084A AT383130B (de) 1984-05-15 1984-05-15 Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin

Publications (2)

Publication Number Publication Date
ES543146A0 ES543146A0 (es) 1986-01-01
ES8603899A1 true ES8603899A1 (es) 1986-01-01

Family

ID=3516711

Family Applications (2)

Application Number Title Priority Date Filing Date
ES543147A Granted ES543147A0 (es) 1984-05-15 1985-05-14 Procedimiento para la obtencion de 1,2-diacil-sn-glicero-3- fosfocolinas y 1,2-diacil-sn-glicero-3-fosfoetanolaminas sustituidas en forma mixta
ES543146A Expired ES8603899A1 (es) 1984-05-15 1985-05-14 Procedimiento para la obtencion de derivados trifenilmetili-cos de la snglicero-3-fosfocolina y sn-glicero-3-fosfoetano-lamina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES543147A Granted ES543147A0 (es) 1984-05-15 1985-05-14 Procedimiento para la obtencion de 1,2-diacil-sn-glicero-3- fosfocolinas y 1,2-diacil-sn-glicero-3-fosfoetanolaminas sustituidas en forma mixta

Country Status (24)

Country Link
US (2) US4622180A (es)
EP (1) EP0161519B1 (es)
JP (1) JPS60252490A (es)
KR (1) KR920009556B1 (es)
CN (1) CN1014791B (es)
AT (2) AT383130B (es)
AU (1) AU565316B2 (es)
BR (1) BR8502293A (es)
CA (1) CA1244462A (es)
DD (2) DD233130A1 (es)
DE (1) DE3563533D1 (es)
DK (2) DK167441C (es)
ES (2) ES543147A0 (es)
FI (1) FI77663C (es)
HU (2) HU203555B (es)
IE (1) IE58511B1 (es)
IL (1) IL75133A (es)
NO (1) NO163100C (es)
NZ (1) NZ212067A (es)
PH (2) PH21831A (es)
SU (2) SU1422999A3 (es)
TR (1) TR22204A (es)
YU (2) YU45720B (es)
ZA (1) ZA853697B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT383130B (de) * 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
DE3638687A1 (de) * 1986-11-13 1988-05-19 Lentia Gmbh Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3-phosphocholinen
AT388165B (de) * 1986-12-10 1989-05-10 Chemie Linz Ag Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3- phosphocholinen
JP2657486B2 (ja) * 1987-02-20 1997-09-24 花王株式会社 洗浄剤組成物
US5144045A (en) * 1990-11-13 1992-09-01 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US7964641B2 (en) * 2003-08-18 2011-06-21 Btg International Limited Treatment of neurodegenerative conditions
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
GB0425932D0 (en) * 2004-11-25 2004-12-29 Btg Int Ltd Structured phospholipids
GB0504362D0 (en) 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
EP2826370A3 (en) * 2008-11-06 2015-04-08 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
CN104017019A (zh) * 2014-06-12 2014-09-03 东南大学 一种氮芥-甘油磷脂酰胆碱化合物的合成方法
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CA2968790A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis
CZ308596B6 (cs) * 2017-04-03 2020-12-23 Ústav molekulární genetiky AV ČR, v. v. i. Deriváty fosfolipidů a jejich použití jako léčiva
PL232298B1 (pl) * 2017-06-30 2019-06-28 Univ Przyrodniczy We Wroclawiu Sposób otrzymywania fosfatydylocholiny zawierającej ibuprofen w pozycji sn-1
PL232663B1 (pl) * 2017-06-30 2019-07-31 Univ Przyrodniczy We Wroclawiu Fosfatydylocholiny oraz sposób ich otrzymywania

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2820893C2 (de) * 1978-05-12 1986-02-20 A. Nattermann & Cie GmbH, 5000 Köln Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
IT1123187B (it) * 1979-09-17 1986-04-30 Lpb Ist Farm Processo per la preparazione di l-alfa-glicerilfosforilcolina
DE3130867A1 (de) * 1981-08-04 1983-02-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Zwischenprodukte zur herstellung von glycerinderivaten
AT383130B (de) * 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin

Also Published As

Publication number Publication date
HU203555B (en) 1991-08-28
DD233130A1 (de) 1986-02-19
NZ212067A (en) 1988-10-28
HUT39454A (en) 1986-09-29
NO163100B (no) 1989-12-27
FI77663C (fi) 1989-04-10
IE58511B1 (en) 1993-10-06
BR8502293A (pt) 1986-01-21
DK212185D0 (da) 1985-05-14
DD245668A1 (de) 1987-05-13
KR850008677A (ko) 1985-12-21
DK167441B (da) 1993-11-01
PH23978A (en) 1990-02-09
ES543146A0 (es) 1986-01-01
CA1244462A (en) 1988-11-08
PH21831A (en) 1988-03-17
ZA853697B (en) 1986-01-29
AU565316B2 (en) 1987-09-10
YU81585A (en) 1987-10-31
US4717512A (en) 1988-01-05
YU45719B (sh) 1992-07-20
NO163100C (no) 1990-04-04
DK98192A (da) 1992-08-03
CN85104463A (zh) 1986-12-10
EP0161519A3 (en) 1986-02-12
HU199486B (en) 1990-02-28
YU45720B (sh) 1992-07-20
FI851781L (fi) 1985-11-16
ATE35416T1 (de) 1988-07-15
JPH0482157B2 (es) 1992-12-25
IE851136L (en) 1985-11-15
IL75133A (en) 1988-12-30
EP0161519B1 (de) 1988-06-29
DE3563533D1 (en) 1988-08-04
FI77663B (fi) 1988-12-30
ES8603900A1 (es) 1986-01-01
TR22204A (tr) 1986-09-24
DK212185A (da) 1985-11-16
ES543147A0 (es) 1986-01-01
EP0161519A2 (de) 1985-11-21
DK98192D0 (da) 1992-08-03
CA1251462C (es) 1989-03-21
KR920009556B1 (ko) 1992-10-19
US4622180A (en) 1986-11-11
CN1014791B (zh) 1991-11-20
SU1422999A3 (ru) 1988-09-07
DK167441C (da) 1994-04-18
SU1400511A3 (ru) 1988-05-30
AT383130B (de) 1987-05-25
AU4244885A (en) 1985-11-21
JPS60252490A (ja) 1985-12-13
ATA159084A (de) 1986-10-15
YU81685A (en) 1987-10-31
FI851781A0 (fi) 1985-05-07
NO851928L (no) 1985-11-18
IL75133A0 (en) 1985-09-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001