YU45720B - POSTOPEK ZA PRIPRAVO NOVIH TRIFENILMETILNIH DERIVATOV Sn-GLICERO-3-FOSFOHOLINA IN SN-GLICERO-3-FOSFOETANOLAMINA - Google Patents

POSTOPEK ZA PRIPRAVO NOVIH TRIFENILMETILNIH DERIVATOV Sn-GLICERO-3-FOSFOHOLINA IN SN-GLICERO-3-FOSFOETANOLAMINA

Info

Publication number
YU45720B
YU45720B YU81685A YU81685A YU45720B YU 45720 B YU45720 B YU 45720B YU 81685 A YU81685 A YU 81685A YU 81685 A YU81685 A YU 81685A YU 45720 B YU45720 B YU 45720B
Authority
YU
Yugoslavia
Prior art keywords
glycero
phosphoethanolamine
phosphocholine
preparation
new
Prior art date
Application number
YU81685A
Other languages
English (en)
Other versions
YU81685A (en
Inventor
F. Paltauf
A. Hermetter
Original Assignee
Chemie Linz Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Aktiengesellschaft filed Critical Chemie Linz Aktiengesellschaft
Publication of YU81685A publication Critical patent/YU81685A/xx
Publication of YU45720B publication Critical patent/YU45720B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Abstract

POSTOPEK ZA PRIPRAVO NOVIH TRIFENILMETILNIH DERIVATOV Sn-GLICERO-3-FOSFOHOLINA IN SN-GLICERO-3-FOSFOETANOLAMINA, s splošno formulo v kateri N pomeni trifenilmetilno skupino, in so ostanki R1, R2 in R3 bodisi enaki in stoje vsakokrat za metilno skupino, ali pa so različni, pri čemer v tem primeru dva izmed ostankov R1, R2 in R3 vedno pomenita vodik in tretji ostanek predstavlja nesubstituirano ali z alkilom z 1 do 6 atomi ogljika, alkoksilom z 1 6 atomi ogljika ali halogenom, enkrat ali večkrat substituirano trifenilmetilno skupino, označen s tem, da sn-glicero-3-fosfonolin ali sn-glicero-3-fosfo-(N-trifenilmetil)-etanolamin s splošno formulo v kateri imajo R1, R2 in R3 v formuli I navedeni pomen, njihove soli z anorganskimi ali organskimi kislinami ali bazami ali njihov kompleks s kovinskimi solmi tritiliramo na kisiku v legi 1 glicerina s presnovo z reaktivnim trimetilfenilnim derivatom s splošno formulo T - X kjer ima T v formuli I definirani pomen in X pomeni reaktivno odcepljivo skupino kot klor, brom ali jod, v inertnem organskem topilu ali zmesi topil, kot dimetilformamidu ali piridinu, pri temperaturah od sobne temperature do vrelišča topila ali komponente topila zmesi z najnižjim vreliščem. Prijava vsebuje še 4 patentna zahtevka.
YU81685A 1984-05-15 1985-05-15 POSTOPEK ZA PRIPRAVO NOVIH TRIFENILMETILNIH DERIVATOV Sn-GLICERO-3-FOSFOHOLINA IN SN-GLICERO-3-FOSFOETANOLAMINA YU45720B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0159084A AT383130B (de) 1984-05-15 1984-05-15 Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin

Publications (2)

Publication Number Publication Date
YU81685A YU81685A (en) 1987-10-31
YU45720B true YU45720B (sh) 1992-07-20

Family

ID=3516711

Family Applications (2)

Application Number Title Priority Date Filing Date
YU81585A YU45719B (sh) 1984-05-15 1985-05-15 Postopek za pripravo mešano substituiranih enantiomerno čistih 1,2-diacil-sn-gli cero-3-fosfoholinov in 1,2-di-acil-sn-glicero-3-fosfoetanolaminov
YU81685A YU45720B (sh) 1984-05-15 1985-05-15 POSTOPEK ZA PRIPRAVO NOVIH TRIFENILMETILNIH DERIVATOV Sn-GLICERO-3-FOSFOHOLINA IN SN-GLICERO-3-FOSFOETANOLAMINA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU81585A YU45719B (sh) 1984-05-15 1985-05-15 Postopek za pripravo mešano substituiranih enantiomerno čistih 1,2-diacil-sn-gli cero-3-fosfoholinov in 1,2-di-acil-sn-glicero-3-fosfoetanolaminov

Country Status (24)

Country Link
US (2) US4622180A (sh)
EP (1) EP0161519B1 (sh)
JP (1) JPS60252490A (sh)
KR (1) KR920009556B1 (sh)
CN (1) CN1014791B (sh)
AT (2) AT383130B (sh)
AU (1) AU565316B2 (sh)
BR (1) BR8502293A (sh)
CA (1) CA1244462A (sh)
DD (2) DD245668A1 (sh)
DE (1) DE3563533D1 (sh)
DK (2) DK167441C (sh)
ES (2) ES8603900A1 (sh)
FI (1) FI77663C (sh)
HU (2) HU203555B (sh)
IE (1) IE58511B1 (sh)
IL (1) IL75133A (sh)
NO (1) NO163100C (sh)
NZ (1) NZ212067A (sh)
PH (2) PH21831A (sh)
SU (2) SU1422999A3 (sh)
TR (1) TR22204A (sh)
YU (2) YU45719B (sh)
ZA (1) ZA853697B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT383130B (de) * 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin
DE3638687A1 (de) * 1986-11-13 1988-05-19 Lentia Gmbh Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3-phosphocholinen
AT388165B (de) * 1986-12-10 1989-05-10 Chemie Linz Ag Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3- phosphocholinen
JP2657486B2 (ja) * 1987-02-20 1997-09-24 花王株式会社 洗浄剤組成物
US5144045A (en) * 1990-11-13 1992-09-01 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
EP1660071A1 (en) * 2003-08-18 2006-05-31 Btg International Limited Treatment of neurodegenerative conditions
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
GB0425932D0 (en) * 2004-11-25 2004-12-29 Btg Int Ltd Structured phospholipids
GB0504362D0 (en) 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
ES2534044T3 (es) * 2008-11-06 2015-04-16 Vascular Biogenics Ltd. Compuestos de lípidos oxidados y usos de los mismos
CN104017019A (zh) * 2014-06-12 2014-09-03 东南大学 一种氮芥-甘油磷脂酰胆碱化合物的合成方法
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
ES2855299T3 (es) 2014-11-26 2021-09-23 Vascular Biogenics Ltd Lípidos oxidados y tratamiento o prevención de la fibrosis
CZ308596B6 (cs) * 2017-04-03 2020-12-23 Ústav molekulární genetiky AV ČR, v. v. i. Deriváty fosfolipidů a jejich použití jako léčiva
PL232663B1 (pl) * 2017-06-30 2019-07-31 Univ Przyrodniczy We Wroclawiu Fosfatydylocholiny oraz sposób ich otrzymywania
PL232298B1 (pl) * 2017-06-30 2019-06-28 Univ Przyrodniczy We Wroclawiu Sposób otrzymywania fosfatydylocholiny zawierającej ibuprofen w pozycji sn-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2820893C2 (de) * 1978-05-12 1986-02-20 A. Nattermann & Cie GmbH, 5000 Köln Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
IT1123187B (it) * 1979-09-17 1986-04-30 Lpb Ist Farm Processo per la preparazione di l-alfa-glicerilfosforilcolina
DE3130867A1 (de) * 1981-08-04 1983-02-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Zwischenprodukte zur herstellung von glycerinderivaten
AT383130B (de) * 1984-05-15 1987-05-25 Chemie Linz Ag Verfahren zur herstellung von an c1 und c2 verschieden substituierten phosphatidylcholinen und phosphatidylethanolaminen ueber die neuen verbindungen 1-0-tritylglycerophosphocholin beziehungsweise (1-0,n-ditrityl)-glycerophosphoethanolamin

Also Published As

Publication number Publication date
NO851928L (no) 1985-11-18
DK167441B (da) 1993-11-01
AU565316B2 (en) 1987-09-10
DK98192A (da) 1992-08-03
NO163100B (no) 1989-12-27
HU203555B (en) 1991-08-28
EP0161519A2 (de) 1985-11-21
JPS60252490A (ja) 1985-12-13
AU4244885A (en) 1985-11-21
ATA159084A (de) 1986-10-15
FI851781L (fi) 1985-11-16
ES543147A0 (es) 1986-01-01
KR850008677A (ko) 1985-12-21
DE3563533D1 (en) 1988-08-04
US4717512A (en) 1988-01-05
HU199486B (en) 1990-02-28
FI77663B (fi) 1988-12-30
ZA853697B (en) 1986-01-29
AT383130B (de) 1987-05-25
CN85104463A (zh) 1986-12-10
CA1244462A (en) 1988-11-08
TR22204A (tr) 1986-09-24
PH23978A (en) 1990-02-09
PH21831A (en) 1988-03-17
EP0161519B1 (de) 1988-06-29
IL75133A0 (en) 1985-09-29
EP0161519A3 (en) 1986-02-12
ES8603899A1 (es) 1986-01-01
SU1422999A3 (ru) 1988-09-07
ATE35416T1 (de) 1988-07-15
DK212185D0 (da) 1985-05-14
IL75133A (en) 1988-12-30
CN1014791B (zh) 1991-11-20
NO163100C (no) 1990-04-04
DD245668A1 (de) 1987-05-13
IE851136L (en) 1985-11-15
FI77663C (fi) 1989-04-10
JPH0482157B2 (sh) 1992-12-25
IE58511B1 (en) 1993-10-06
ES8603900A1 (es) 1986-01-01
DK98192D0 (da) 1992-08-03
ES543146A0 (es) 1986-01-01
SU1400511A3 (ru) 1988-05-30
BR8502293A (pt) 1986-01-21
DK167441C (da) 1994-04-18
FI851781A0 (fi) 1985-05-07
YU45719B (sh) 1992-07-20
KR920009556B1 (ko) 1992-10-19
YU81685A (en) 1987-10-31
HUT39454A (en) 1986-09-29
US4622180A (en) 1986-11-11
NZ212067A (en) 1988-10-28
DD233130A1 (de) 1986-02-19
CA1251462C (sh) 1989-03-21
DK212185A (da) 1985-11-16
YU81585A (en) 1987-10-31

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