DK554084A - 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol - Google Patents

26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol Download PDF

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Publication number
DK554084A
DK554084A DK554084A DK554084A DK554084A DK 554084 A DK554084 A DK 554084A DK 554084 A DK554084 A DK 554084A DK 554084 A DK554084 A DK 554084A DK 554084 A DK554084 A DK 554084A
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DK
Denmark
Prior art keywords
dihydroxycholesterol
1alpha
hexafluoro
vitamin
derivatives
Prior art date
Application number
DK554084A
Other languages
English (en)
Other versions
DK165695C (da
DK165695B (da
DK554084D0 (da
Inventor
Hector F Deluca
Yoko Tanaka
Nobuo Ikekawa
Yoshiro Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK554084A publication Critical patent/DK554084A/da
Publication of DK554084D0 publication Critical patent/DK554084D0/da
Publication of DK165695B publication Critical patent/DK165695B/da
Application granted granted Critical
Publication of DK165695C publication Critical patent/DK165695C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK554084A 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol DK165695C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28679081 1981-07-27
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US8200909 1982-07-06
PCT/US1982/000909 WO1983000335A1 (en) 1981-07-27 1982-07-06 26,26,26,27,27,27-HEXAFLUORO-1'alpha',25-DIHYDROXYCHOLECALCIFEROL AND PROCESS FOR PREPARING SAME
DK137083 1983-03-25
DK137083A DK162282C (da) 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden

Publications (4)

Publication Number Publication Date
DK554084A true DK554084A (da) 1984-11-22
DK554084D0 DK554084D0 (da) 1984-11-22
DK165695B DK165695B (da) 1993-01-04
DK165695C DK165695C (da) 1993-06-07

Family

ID=23100174

Family Applications (2)

Application Number Title Priority Date Filing Date
DK137083A DK162282C (da) 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK137083A DK162282C (da) 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden

Country Status (14)

Country Link
US (1) US4358406A (da)
JP (1) JPS58501176A (da)
AU (2) AU552210B2 (da)
BE (1) BE893943A (da)
CH (2) CH656134A5 (da)
DE (2) DE3248900T1 (da)
DK (2) DK162282C (da)
FR (1) FR2510566B1 (da)
GB (2) GB2102806B (da)
IE (2) IE54370B1 (da)
IL (5) IL76090A (da)
IT (1) IT1157309B (da)
NL (1) NL8220265A (da)
WO (1) WO1983000335A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
ATE253921T1 (de) * 1991-05-06 2003-11-15 Procter & Gamble Kombinationen aus calzium und vitamin d
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
CA2147264C (en) * 1992-10-16 2006-05-16 Tetsuhiro Mikami Vitamin d derivatives and a process for producing them
BR9405735A (pt) * 1993-02-19 1995-12-05 Wisconsin Alumni Res Found Uso de 26,26,26,27,27,27-hexaflúor-1-alfa 25-dihidróxi colecalciferol para o tratamento de distúrbios do metabolismo do cálcio
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
IL139241A0 (en) * 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
JP2011508743A (ja) * 2007-12-28 2011-03-17 ウィスコンシン アラムナイ リサーチ ファンデーション （２０ｓ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体
CA2981549A1 (en) 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
JPS58501176A (ja) 1983-07-21
US4358406A (en) 1982-11-09
DE3248900C2 (da) 1990-12-13
IL76090A (en) 1987-12-31
IL76090A0 (en) 1985-12-31
WO1983000335A1 (en) 1983-02-03
DE3248900T1 (de) 1983-07-07
GB2118556A (en) 1983-11-02
DK137083D0 (da) 1983-03-25
DK165695C (da) 1993-06-07
IL66351A (en) 1987-12-31
GB8311517D0 (en) 1983-06-02
BE893943A (fr) 1982-11-16
IT1157309B (it) 1987-02-11
DE3250034C2 (da) 1991-02-28
AU8760582A (en) 1983-03-17
GB2102806A (en) 1983-02-09
NL8220265A (nl) 1983-06-01
IE54369B1 (en) 1989-09-13
DK162282B (da) 1991-10-07
IL76091A0 (en) 1985-12-31
GB2102806B (en) 1985-02-27
IL66351A0 (en) 1982-11-30
JPH0348903B2 (da) 1991-07-25
DK162282C (da) 1992-03-16
AU586267B2 (en) 1989-07-06
FR2510566A1 (fr) 1983-02-04
IL76091A (en) 1987-12-31
GB2118556B (en) 1985-02-27
CH656134A5 (de) 1986-06-13
CH655307A5 (de) 1986-04-15
AU552210B2 (en) 1986-05-22
AU6056086A (en) 1986-12-18
FR2510566B1 (fr) 1985-06-28
DK165695B (da) 1993-01-04
IE821797L (en) 1983-01-27
IE891226L (en) 1983-01-27
DK554084D0 (da) 1984-11-22
DK137083A (da) 1983-03-25
IT8222574A0 (it) 1982-07-26
IE54370B1 (en) 1989-09-13

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