DK162282C - Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden - Google Patents
Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaadenInfo
- Publication number
- DK162282C DK162282C DK137083A DK137083A DK162282C DK 162282 C DK162282 C DK 162282C DK 137083 A DK137083 A DK 137083A DK 137083 A DK137083 A DK 137083A DK 162282 C DK162282 C DK 162282C
- Authority
- DK
- Denmark
- Prior art keywords
- 1alfa
- hexafluor
- dihydroxycholecalciferoles
- trihyd
- 3beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK554084A DK165695C (da) | 1981-07-27 | 1984-11-22 | 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28679081 | 1981-07-27 | ||
US06/286,790 US4358406A (en) | 1981-07-27 | 1981-07-27 | 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same |
US8200909 | 1982-07-06 | ||
PCT/US1982/000909 WO1983000335A1 (en) | 1981-07-27 | 1982-07-06 | 26,26,26,27,27,27-HEXAFLUORO-1'alpha',25-DIHYDROXYCHOLECALCIFEROL AND PROCESS FOR PREPARING SAME |
Publications (4)
Publication Number | Publication Date |
---|---|
DK137083A DK137083A (da) | 1983-03-25 |
DK137083D0 DK137083D0 (da) | 1983-03-25 |
DK162282B DK162282B (da) | 1991-10-07 |
DK162282C true DK162282C (da) | 1992-03-16 |
Family
ID=23100174
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK137083A DK162282C (da) | 1981-07-27 | 1983-03-25 | Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden |
DK554084A DK165695C (da) | 1981-07-27 | 1984-11-22 | 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK554084A DK165695C (da) | 1981-07-27 | 1984-11-22 | 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol |
Country Status (14)
Country | Link |
---|---|
US (1) | US4358406A (da) |
JP (1) | JPS58501176A (da) |
AU (2) | AU552210B2 (da) |
BE (1) | BE893943A (da) |
CH (2) | CH655307A5 (da) |
DE (2) | DE3250034C2 (da) |
DK (2) | DK162282C (da) |
FR (1) | FR2510566B1 (da) |
GB (2) | GB2102806B (da) |
IE (2) | IE54369B1 (da) |
IL (5) | IL66351A (da) |
IT (1) | IT1157309B (da) |
NL (1) | NL8220265A (da) |
WO (1) | WO1983000335A1 (da) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4634692A (en) * | 1981-08-28 | 1987-01-06 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol |
US4411833A (en) * | 1982-05-26 | 1983-10-25 | Wisconsin Alumni Research Foundation | Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol |
US4448726A (en) * | 1983-05-11 | 1984-05-15 | Wisconsin Alumni Research Foundation | Ring A- and triene-modified vitamin D compounds |
US4613594A (en) * | 1984-11-16 | 1986-09-23 | Hoffmann-La Roche Inc. | Fluorinated vitamin D3 compounds |
ZA859138B (en) * | 1984-12-19 | 1986-08-27 | Hoffmann La Roche | Cholecalciferol derivatives |
EP0205025A1 (en) * | 1985-05-27 | 1986-12-17 | Sumitomo Pharmaceuticals Company, Limited | Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient |
US4619920A (en) * | 1985-09-16 | 1986-10-28 | Wisconsin Alumni Research Foundation | 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3 |
JPH0764804B2 (ja) * | 1986-04-25 | 1995-07-12 | 住友製薬株式会社 | 活性型ビタミンd3のフッ素誘導体 |
CA1314872C (en) | 1986-04-25 | 1993-03-23 | Toshio Nishizawa | Fluorine derivatives of vitamin d _and process for producing the same |
US4853378A (en) * | 1986-10-20 | 1989-08-01 | Sumitomo Chemical Company, Limited | Fluorine derivatives of vitamin D3 and process for producing the same |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
US5316770A (en) * | 1989-02-16 | 1994-05-31 | University Of Georgia Research Foundation, Inc. | Vitamin D derivative feed compositions and methods of use |
US5366736A (en) * | 1989-02-16 | 1994-11-22 | University Of Georgia Research Foundation, Inc. | Vitamin D derivative feed compositions and methods of use |
AU5185790A (en) * | 1989-02-16 | 1990-09-05 | University Of Georgia Research Foundation, Inc., The | Treatment of tibial dyschondroplasia |
JP3708115B2 (ja) * | 1991-05-06 | 2005-10-19 | ザ プロクター アンド ギャンブル カンパニー | 混合カルシウム及びビタミンd補給品 |
CA2096105A1 (en) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Vitamin d3 fluorinated analogs |
US5753638A (en) * | 1992-10-07 | 1998-05-19 | Hoffmann-La Roche Inc. | Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs |
CA2147264C (en) * | 1992-10-16 | 2006-05-16 | Tetsuhiro Mikami | Vitamin d derivatives and a process for producing them |
US5571802A (en) * | 1993-02-19 | 1996-11-05 | Wisconsin Alumni Research Foundation | Method of treating post menopausal osteoporosis with hexafluro-vitamin D |
US5547947A (en) * | 1993-03-11 | 1996-08-20 | Hoffmann-La Roche Inc. | Methods of treatment |
US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
IL139241A0 (en) | 1998-05-13 | 2001-11-25 | Novo Nordisk As | Meiosis regulating compounds |
US6080879A (en) * | 1998-05-19 | 2000-06-27 | Tetrionics, Inc. | Hexafluoro-vitamin synthesis and crystallization method, solvent and product |
EP2240439B1 (en) * | 2007-12-28 | 2015-03-18 | Wisconsin Alumni Research Foundation | (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs |
JP5932339B2 (ja) | 2009-01-27 | 2016-06-08 | バーグ エルエルシー | 化学療法に付随する副作用を軽減するためのビタミンd3およびその類似体 |
IN2012DN02137A (da) | 2009-08-14 | 2015-08-07 | Berg Biosystems Llc | |
SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
ES2536256B2 (es) | 2013-11-20 | 2016-02-01 | Universidade De Santiago De Compostela | Análogos de vitamina d con interés farmacéutico |
CN111960938B (zh) * | 2020-08-20 | 2022-06-17 | 甘肃皓天医药科技有限责任公司 | 用于制备氟骨化醇的中间体的制备方法及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL45897A (en) * | 1974-10-22 | 1978-12-17 | Yeda Res & Dev | Process for the preparation of 1 hydroxy-provitamin d3 |
US4199518A (en) * | 1978-03-30 | 1980-04-22 | Diamond Shamrock Corporation | 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones |
PH16989A (en) * | 1978-11-07 | 1984-05-04 | Res Inst Medicine Chem | Process for the preparation of 1-hydroxylated vitamin d compounds |
US4226788A (en) * | 1979-03-28 | 1980-10-07 | Wisconsin Alumni Research Foundation | 24,24-Difluoro-1α,25-dihydroxycholecalciferol |
US4248791A (en) * | 1980-02-04 | 1981-02-03 | Wisconsin Alumni Research Foundation | 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol |
-
1981
- 1981-07-27 US US06/286,790 patent/US4358406A/en not_active Expired - Lifetime
-
1982
- 1982-07-06 AU AU87605/82A patent/AU552210B2/en not_active Ceased
- 1982-07-06 WO PCT/US1982/000909 patent/WO1983000335A1/en active Application Filing
- 1982-07-06 DE DE3250034A patent/DE3250034C2/de not_active Expired - Lifetime
- 1982-07-06 CH CH1788/83A patent/CH655307A5/de not_active IP Right Cessation
- 1982-07-06 CH CH2891/85A patent/CH656134A5/de not_active IP Right Cessation
- 1982-07-06 JP JP57502411A patent/JPS58501176A/ja active Granted
- 1982-07-06 NL NL8220265A patent/NL8220265A/nl not_active Application Discontinuation
- 1982-07-06 DE DE823248900T patent/DE3248900T1/de active Granted
- 1982-07-19 IL IL66351A patent/IL66351A/xx not_active IP Right Cessation
- 1982-07-19 IL IL76090A patent/IL76090A/xx not_active IP Right Cessation
- 1982-07-19 IL IL76091A patent/IL76091A/xx not_active IP Right Cessation
- 1982-07-26 GB GB08221573A patent/GB2102806B/en not_active Expired
- 1982-07-26 FR FR8212994A patent/FR2510566B1/fr not_active Expired
- 1982-07-26 IT IT22574/82A patent/IT1157309B/it active
- 1982-07-26 BE BE0/208679A patent/BE893943A/fr not_active IP Right Cessation
- 1982-07-26 IE IE1797/82A patent/IE54369B1/en not_active IP Right Cessation
- 1982-07-26 IE IE1226/89A patent/IE54370B1/en not_active IP Right Cessation
-
1983
- 1983-03-25 DK DK137083A patent/DK162282C/da not_active IP Right Cessation
- 1983-04-27 GB GB08311517A patent/GB2118556B/en not_active Expired
-
1984
- 1984-11-22 DK DK554084A patent/DK165695C/da not_active IP Right Cessation
-
1985
- 1985-08-14 IL IL76090A patent/IL76090A0/xx unknown
- 1985-08-14 IL IL76091A patent/IL76091A0/xx unknown
-
1986
- 1986-07-25 AU AU60560/86A patent/AU586267B2/en not_active Ceased
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK162282C (da) | Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden | |
DK162601C (da) | Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion | |
DK160943C (da) | Analogifremgangsmaade til fremstilling af acyloxyalkyl-6-(alfa, alfa-disubstituerede acetamido)penicillanater samt et udgangsmateriale til fremstilling heraf | |
NO162121C (no) | Fremgangsmaate ved fremstilling av titan, samt apparat forutfoerelse av fremgangsmaaten. | |
DK268385D0 (da) | Lysfoelsomme mikrokapsler og lysfoelsomt materiale, indeholdende disse, samt anvendelse deraf til dannelse af flerfarvede billeder | |
NO158630C (no) | Poroest, tverrbundet polymert blokkmateriale, samt fremgangsmaate for fremstilling av et slikt. | |
NO871830D0 (no) | Komposittelektroder, framgangsmaate for framstilling av disse samt apparat der elektrodene benyttes. | |
DK528982A (da) | Fremgangsmaade til fremstilling af 13,14-didehydro-prostaglandiner | |
NO832610L (no) | Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse | |
DK145787A (da) | Fremgangsmaade til maling af fortrinsvis hoejviskose vaeskers flydeegenskaber samt apparat til udfoerelse af fremgangsmaaden | |
DK158664C (da) | Analogifremgangsmaade til fremstilling af benzoxazinoner og benzoxazolinoner samt forbindelser til anvendelse ved fremgangsmaaden. | |
DK631986A (da) | Fremgangsmaade samt apparat til kalcinering. | |
DK446082A (da) | Fremgangsmaade til fremstilling af chlordioxid samt apparat til anvendelse derved | |
DK149846C (da) | Analogifremgangsmaade til fremstilling af n,n'-bis-tetrahydro-isoquinolyldisulfonylimider | |
DK369483A (da) | Stabiliseret herbicidsammensaetning samt fremgangsmaade til fremstilling af samme | |
NO821270L (no) | Fremgangsmaate ved fremstilling av metallklorider, samt anordning for utfoerelse av fremgangsmaaten | |
DK520279A (da) | Pyrrolo-eller pyrido(2,1-c)(1,4)thiaziner eller-thiazepiner samt fremgangsmaade til anvendelse af saadanne forbindelser som mellemprodukter | |
DK174784D0 (da) | Fremgangsmaade,apparat samt hylstre til stopning | |
DK215681A (da) | Fremgangsmaade samt apparat til frmstilling af alkansulfonylchlorider | |
DK165245C (da) | 5-phenyl-5h-indenooe1,2-daapyrimidiner, fremgangsmaade til fremstilling af disse samt anvendelse af forbindelserne | |
DK523781A (da) | Fremgangsmaade til fremstilling af benzylpyrimidiner samt mellemprodukt for disse | |
DK7483A (da) | Fremgangsmaade til fremstilling af 6-aminoalkylpencillansyre-1,1-dioxider samt derivater deraf | |
DK148883C (da) | Analogifremgangsmaade til fremstilling af ergolinderivater samt ergolinderivater til anvendelse som udgangsmateriale hertil | |
DK456779A (da) | Acyl-1h-1,2,4-triazolderivater til anvendelse som antireproduktive midler samt fremgangsmaade til fremstilling af disse | |
EP0104258A4 (en) | STICK FOR CHROMATOGRAPHY AND METHOD FOR DEVELOPING A SAMPLE USING THE SAME. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |