DK137083D0 - Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholecalciferol og mellemprodukter til brug herved - Google Patents

Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholecalciferol og mellemprodukter til brug herved

Info

Publication number
DK137083D0
DK137083D0 DK1370/83A DK137083A DK137083D0 DK 137083 D0 DK137083 D0 DK 137083D0 DK 1370/83 A DK1370/83 A DK 1370/83A DK 137083 A DK137083 A DK 137083A DK 137083 D0 DK137083 D0 DK 137083D0
Authority
DK
Denmark
Prior art keywords
hexafluorlalfa
dihydroxycholecalciferol
intermediates
preparing
Prior art date
Application number
DK1370/83A
Other languages
English (en)
Other versions
DK162282B (da
DK162282C (da
DK137083A (da
Inventor
Hector F Deluca
Yoko Tanaka
Nobuo Ikekawa
Yoshiro Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK137083A publication Critical patent/DK137083A/da
Publication of DK137083D0 publication Critical patent/DK137083D0/da
Priority to DK554084A priority Critical patent/DK165695C/da
Publication of DK162282B publication Critical patent/DK162282B/da
Application granted granted Critical
Publication of DK162282C publication Critical patent/DK162282C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK137083A 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden DK162282C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US28679081 1981-07-27
US8200909 1982-07-06
PCT/US1982/000909 WO1983000335A1 (en) 1981-07-27 1982-07-06 26,26,26,27,27,27-HEXAFLUORO-1'alpha',25-DIHYDROXYCHOLECALCIFEROL AND PROCESS FOR PREPARING SAME

Publications (4)

Publication Number Publication Date
DK137083A DK137083A (da) 1983-03-25
DK137083D0 true DK137083D0 (da) 1983-03-25
DK162282B DK162282B (da) 1991-10-07
DK162282C DK162282C (da) 1992-03-16

Family

ID=23100174

Family Applications (2)

Application Number Title Priority Date Filing Date
DK137083A DK162282C (da) 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Country Status (14)

Country Link
US (1) US4358406A (da)
JP (1) JPS58501176A (da)
AU (2) AU552210B2 (da)
BE (1) BE893943A (da)
CH (2) CH656134A5 (da)
DE (2) DE3250034C2 (da)
DK (2) DK162282C (da)
FR (1) FR2510566B1 (da)
GB (2) GB2102806B (da)
IE (2) IE54370B1 (da)
IL (5) IL76091A (da)
IT (1) IT1157309B (da)
NL (1) NL8220265A (da)
WO (1) WO1983000335A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
CA2102210C (en) * 1991-05-06 1998-08-04 Mark Benson Andon Combined calcium and vitamin d supplements
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
EP0665221B1 (en) * 1992-10-16 2000-02-23 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivative and process for producing the same
JPH08507073A (ja) * 1993-02-19 1996-07-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン カルシウム代謝障害の治療のための２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１アルファ，２５−ジヒドロキシコレカルシフェロールの使用
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
EP2240439B1 (en) * 2007-12-28 2015-03-18 Wisconsin Alumni Research Foundation (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs
BRPI1007415A2 (pt) 2009-01-27 2016-02-16 Berg Biosystems Llc vitamina d3 e análogos da mesma para aliviar os efeitos colaterais associados com quimioterapia
KR101880032B1 (ko) 2009-08-14 2018-07-20 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
CN105492081A (zh) 2013-05-29 2016-04-13 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
ES2536256B2 (es) 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
IL66351A0 (en) 1982-11-30
CH656134A5 (de) 1986-06-13
IE891226L (en) 1983-01-27
DK554084D0 (da) 1984-11-22
GB2102806A (en) 1983-02-09
AU8760582A (en) 1983-03-17
DE3248900C2 (da) 1990-12-13
IL76090A (en) 1987-12-31
DK162282B (da) 1991-10-07
IL76091A0 (en) 1985-12-31
IL76090A0 (en) 1985-12-31
IE821797L (en) 1983-01-27
DE3248900T1 (de) 1983-07-07
IL76091A (en) 1987-12-31
AU586267B2 (en) 1989-07-06
DE3250034C2 (da) 1991-02-28
DK165695C (da) 1993-06-07
JPH0348903B2 (da) 1991-07-25
DK162282C (da) 1992-03-16
IE54369B1 (en) 1989-09-13
FR2510566B1 (fr) 1985-06-28
GB2118556A (en) 1983-11-02
DK554084A (da) 1984-11-22
GB2102806B (en) 1985-02-27
US4358406A (en) 1982-11-09
IT8222574A0 (it) 1982-07-26
DK165695B (da) 1993-01-04
IT1157309B (it) 1987-02-11
AU552210B2 (en) 1986-05-22
DK137083A (da) 1983-03-25
GB2118556B (en) 1985-02-27
IE54370B1 (en) 1989-09-13
IL66351A (en) 1987-12-31
GB8311517D0 (en) 1983-06-02
NL8220265A (nl) 1983-06-01
BE893943A (fr) 1982-11-16
CH655307A5 (de) 1986-04-15
JPS58501176A (ja) 1983-07-21
FR2510566A1 (fr) 1983-02-04
WO1983000335A1 (en) 1983-02-03
AU6056086A (en) 1986-12-18

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