NO832610L - Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse - Google Patents

Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse

Info

Publication number
NO832610L
NO832610L NO832610A NO832610A NO832610L NO 832610 L NO832610 L NO 832610L NO 832610 A NO832610 A NO 832610A NO 832610 A NO832610 A NO 832610A NO 832610 L NO832610 L NO 832610L
Authority
NO
Norway
Prior art keywords
morpholinyl
daunorubicin
doxorubicin
analogs
derivatives
Prior art date
Application number
NO832610A
Other languages
English (en)
Other versions
NO157146C (no
NO157146B (no
Inventor
Carol Walker Mosher
George Low Tong
Edward Mcintosh Acton
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of NO832610L publication Critical patent/NO832610L/no
Publication of NO157146B publication Critical patent/NO157146B/no
Publication of NO157146C publication Critical patent/NO157146C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
NO832610A 1982-07-20 1983-07-18 Analogifremgangsmaate ved fremstilling av terapeutisk, aktive derivater av morfolinyl-daunorbicin og morfolinyl-doksorubicin. NO157146C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40012082A 1982-07-20 1982-07-20
US06/496,122 US4464529A (en) 1982-07-20 1983-05-24 Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Publications (3)

Publication Number Publication Date
NO832610L true NO832610L (no) 1984-01-23
NO157146B NO157146B (no) 1987-10-19
NO157146C NO157146C (no) 1988-01-27

Family

ID=27016900

Family Applications (1)

Application Number Title Priority Date Filing Date
NO832610A NO157146C (no) 1982-07-20 1983-07-18 Analogifremgangsmaate ved fremstilling av terapeutisk, aktive derivater av morfolinyl-daunorbicin og morfolinyl-doksorubicin.

Country Status (24)

Country Link
US (1) US4464529A (no)
KR (1) KR880002461B1 (no)
AT (1) AT381319B (no)
AU (1) AU555902B2 (no)
BE (1) BE897312A (no)
CA (1) CA1239396A (no)
CH (1) CH655729A5 (no)
DE (1) DE3325816A1 (no)
DK (1) DK158269C (no)
ES (2) ES8501415A1 (no)
FI (1) FI75174C (no)
FR (1) FR2530640B1 (no)
GB (1) GB2124224B (no)
GR (1) GR78885B (no)
IE (1) IE55795B1 (no)
IL (1) IL69260A (no)
IT (1) IT1163818B (no)
NL (1) NL188905C (no)
NO (1) NO157146C (no)
NZ (1) NZ204911A (no)
PH (1) PH21860A (no)
PT (1) PT77060B (no)
SE (1) SE459921B (no)
YU (2) YU155083A (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) * 1984-03-09 1987-01-16 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) * 1984-06-15 1988-01-15 Hoechst Lab Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4705850A (en) * 1984-10-25 1987-11-10 Sri International C-glycosidic adriamycin analogs
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
EP2588490B1 (en) 2010-07-02 2017-02-22 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
EP3191134B1 (en) 2014-09-12 2019-11-20 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4202967A (en) * 1978-10-02 1980-05-13 Sri International N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) * 1981-03-23 1982-02-02 Sri International 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

Also Published As

Publication number Publication date
DE3325816A1 (de) 1984-01-26
US4464529A (en) 1984-08-07
GB2124224B (en) 1985-12-04
IT1163818B (it) 1987-04-08
CH655729A5 (de) 1986-05-15
IL69260A0 (en) 1983-11-30
GR78885B (no) 1984-10-02
AU555902B2 (en) 1986-10-16
FI75174C (fi) 1988-05-09
NL188905C (nl) 1992-11-02
SE8304045D0 (sv) 1983-07-19
NL8302586A (nl) 1984-02-16
CA1239396A (en) 1988-07-19
FI832637A (fi) 1984-01-21
NO157146C (no) 1988-01-27
GB8319165D0 (en) 1983-08-17
FI75174B (fi) 1988-01-29
DK158269C (da) 1990-10-08
PH21860A (en) 1988-03-25
DK158269B (da) 1990-04-23
KR880002461B1 (ko) 1988-11-14
ATA260883A (de) 1986-02-15
PT77060A (en) 1983-08-01
IT8322143A1 (it) 1985-01-20
DK332983A (da) 1984-01-21
KR840005443A (ko) 1984-11-12
DE3325816C2 (no) 1990-05-03
FR2530640A1 (fr) 1984-01-27
FI832637A0 (fi) 1983-07-19
NO157146B (no) 1987-10-19
DK332983D0 (da) 1983-07-19
SE8304045L (sv) 1984-01-21
FR2530640B1 (fr) 1985-07-12
NZ204911A (en) 1986-04-11
ES524271A0 (es) 1984-11-16
GB2124224A (en) 1984-02-15
PT77060B (en) 1986-04-09
ES8501415A1 (es) 1984-11-16
IT8322143A0 (it) 1983-07-20
BE897312A (fr) 1984-01-18
IL69260A (en) 1987-03-31
IE55795B1 (en) 1991-01-16
ES530593A0 (es) 1985-11-01
AT381319B (de) 1986-09-25
AU1694683A (en) 1984-01-26
YU155083A (en) 1986-02-28
ES8602032A1 (es) 1985-11-01
SE459921B (sv) 1989-08-21
YU140585A (en) 1986-02-28
IE831680L (en) 1984-01-20

Similar Documents

Publication Publication Date Title
NO832610L (no) Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse
NO166218C (no) Fremgangsmaate for hydrolysering av cos.
DK307883A (da) Carbostyrilderivater samt fremgangsmaade til fremstilling deraf
NO158461C (no) Analogifremgangsmaate for fremstilling av fenyl-piperidin-propanol-derivater.
RO90861A (ro) Procedeu pentru prepararea etielnglicolului
NO162158C (no) Fremgangsmaate for fremstilling av polyolefiner.
NO843956L (no) Fremgangsmaate for fremstilling av karboksyalkenamido-cefalosporiner
RO86213A (ro) Procedeu pentru prepararea izobutenei
NO834197L (no) Fremgangsmaate for fremstilling av et sprengstoff
DK409784D0 (da) Substituerede phenyl-alifatiske isoxaler, fremgangsmaade til fremstilling deraf samt antivirale praeparater indeholdende disse
NO812464L (no) Fremgangsmaate til fremstilling av antiviralt virksomme forbindelser, samt preparater inneholdende disse
FI832257L (fi) Foerfarande foer framstaellning av fenolskum med hjaelp av vattenfria arylsulfonsyrakatalyter
DK446082A (da) Fremgangsmaade til fremstilling af chlordioxid samt apparat til anvendelse derved
AR229519A1 (es) Procedimiento de preparacion de derivados de 2,3-dihidro-9-fenil-1h-pirazolo(1,2-a)-indazolio
NO159716C (no) Apparat til fremstilling av mellomofaseagglomerater.
NO830176L (no) Fremgangsmaate for fremstilling av ultrarent toriumfluorid
NO160335C (no) Fremgangsmaate for fremstilling av roerkokiller.
ES533618A0 (es) Procedimiento de preparacion de nuevos derivados de guarnina.
NO162018C (no) Fremgangsmaate for fremstilling av 4-metyl-5-alkyltiometylimidazoler.
NO811628L (no) Fremgangsmaate for fremstilling av karbapenam- og karbapen-2-em-derivater.
DK423284A (da) Naphthalenylimidazopyridin og derivater heraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK364483D0 (da) 14-aminosteroid-derivater samt fremgangsmade til fremstilling deraf
NO831874L (no) Fremgangsmaate for fremstilling av trifenylbuten-derivater
ES522652A0 (es) Procedimiento de preparacion de derivados de piperacina.
DK537081A (da) Fremgangsmaade til fremstilling af estra-4,9-dienderivater