ES8602032A1 - Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina

Info

Publication number
ES8602032A1
ES8602032A1 ES530593A ES530593A ES8602032A1 ES 8602032 A1 ES8602032 A1 ES 8602032A1 ES 530593 A ES530593 A ES 530593A ES 530593 A ES530593 A ES 530593A ES 8602032 A1 ES8602032 A1 ES 8602032A1
Authority
ES
Spain
Prior art keywords
morpholinyl
daunorubicin
doxorubicin
analogues
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530593A
Other languages
English (en)
Other versions
ES530593A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of ES8602032A1 publication Critical patent/ES8602032A1/es
Publication of ES530593A0 publication Critical patent/ES530593A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE DAUNORRUBICINA Y DOXORRUBICINA. COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN GRUPO 14-HIDROXI, SI ESTA PRESENTE, ADECUADAMENTE BLOQUEADO, CON CUALQUIER GRUPO PROTECTOR LABIL A LOS ACIDOS DEBILES, CON UN EXCESO DE AMONIACO ALCOHOLICO A UNA TEMPERATURA ENTRE -25 Y 25C Y, SI ES NECESARIO DESPUES DE ESCINDIR EL GRUPO PROTECTOR LABIL A LOS ACIDOS DEBILES, AISLAR Y PURIFICAR EL COMPUESTO OBTENIDO DE FORMULA (I) EN DONDE R ESTA SELECCIONADO ENTRE -CO-CH3, -CHOH-CH3, -CO-CH2OH Y -CHOH-CH2OH Y A ESTA SELECCIONADO ENTRE CN Y H. TIENEN APLICACIONES FARMACEUTICAS POR SER AGENTES ANTITUMORALES Y PODERSE EMPLEAR EN EL TRATAMIENTO DE DIVERSOS TIPOS DE CANCER.
ES530593A 1982-07-20 1984-03-14 Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina Granted ES530593A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40012082A 1982-07-20 1982-07-20
US06/496,122 US4464529A (en) 1982-07-20 1983-05-24 Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Publications (2)

Publication Number Publication Date
ES8602032A1 true ES8602032A1 (es) 1985-11-01
ES530593A0 ES530593A0 (es) 1985-11-01

Family

ID=27016900

Family Applications (2)

Application Number Title Priority Date Filing Date
ES524271A Expired ES8501415A1 (es) 1982-07-20 1983-07-19 Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina.
ES530593A Granted ES530593A0 (es) 1982-07-20 1984-03-14 Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES524271A Expired ES8501415A1 (es) 1982-07-20 1983-07-19 Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina.

Country Status (24)

Country Link
US (1) US4464529A (es)
KR (1) KR880002461B1 (es)
AT (1) AT381319B (es)
AU (1) AU555902B2 (es)
BE (1) BE897312A (es)
CA (1) CA1239396A (es)
CH (1) CH655729A5 (es)
DE (1) DE3325816A1 (es)
DK (1) DK158269C (es)
ES (2) ES8501415A1 (es)
FI (1) FI75174C (es)
FR (1) FR2530640B1 (es)
GB (1) GB2124224B (es)
GR (1) GR78885B (es)
IE (1) IE55795B1 (es)
IL (1) IL69260A (es)
IT (1) IT1163818B (es)
NL (1) NL188905C (es)
NO (1) NO157146C (es)
NZ (1) NZ204911A (es)
PH (1) PH21860A (es)
PT (1) PT77060B (es)
SE (1) SE459921B (es)
YU (2) YU155083A (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) * 1984-03-09 1987-01-16 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) * 1984-06-15 1988-01-15 Hoechst Lab Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4705850A (en) * 1984-10-25 1987-11-10 Sri International C-glycosidic adriamycin analogs
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
WO2001049698A1 (en) * 1999-12-29 2001-07-12 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
CA2721140C (en) * 2008-04-11 2016-02-09 Tianjin Hemay Bio-Tech Co. Ltd. Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
EP3191134B1 (en) 2014-09-12 2019-11-20 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4202967A (en) * 1978-10-02 1980-05-13 Sri International N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) * 1981-03-23 1982-02-02 Sri International 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

Also Published As

Publication number Publication date
ES524271A0 (es) 1984-11-16
SE8304045L (sv) 1984-01-21
IT8322143A1 (it) 1985-01-20
DE3325816A1 (de) 1984-01-26
YU140585A (en) 1986-02-28
GR78885B (es) 1984-10-02
AT381319B (de) 1986-09-25
AU1694683A (en) 1984-01-26
IE55795B1 (en) 1991-01-16
KR880002461B1 (ko) 1988-11-14
DK332983A (da) 1984-01-21
NZ204911A (en) 1986-04-11
IT8322143A0 (it) 1983-07-20
IE831680L (en) 1984-01-20
NO832610L (no) 1984-01-23
ES8501415A1 (es) 1984-11-16
US4464529A (en) 1984-08-07
BE897312A (fr) 1984-01-18
NO157146C (no) 1988-01-27
GB2124224A (en) 1984-02-15
CH655729A5 (de) 1986-05-15
PT77060A (en) 1983-08-01
YU155083A (en) 1986-02-28
FI75174B (fi) 1988-01-29
IL69260A (en) 1987-03-31
DE3325816C2 (es) 1990-05-03
PH21860A (en) 1988-03-25
CA1239396A (en) 1988-07-19
GB2124224B (en) 1985-12-04
KR840005443A (ko) 1984-11-12
SE8304045D0 (sv) 1983-07-19
FI75174C (fi) 1988-05-09
IL69260A0 (en) 1983-11-30
ES530593A0 (es) 1985-11-01
DK332983D0 (da) 1983-07-19
ATA260883A (de) 1986-02-15
GB8319165D0 (en) 1983-08-17
SE459921B (sv) 1989-08-21
AU555902B2 (en) 1986-10-16
PT77060B (en) 1986-04-09
DK158269C (da) 1990-10-08
FR2530640A1 (fr) 1984-01-27
IT1163818B (it) 1987-04-08
FI832637A0 (fi) 1983-07-19
FR2530640B1 (fr) 1985-07-12
NO157146B (no) 1987-10-19
NL188905C (nl) 1992-11-02
DK158269B (da) 1990-04-23
NL8302586A (nl) 1984-02-16
FI832637A (fi) 1984-01-21

Similar Documents

Publication Publication Date Title
ES8602032A1 (es) Un procedimiento para la preparacion de nuevos derivados de daunorrubicina y doxorrubicina
NZ219222A (en) A composition for priming hard tissue
ES8706664A1 (es) Procedimiento para preparar compuestos carbostirilicos
ES8403897A1 (es) Procedimiento para la fabricacion de nuevos derivados de la amino-3 quinuclidina
ES8607252A1 (es) Procedimiento para preparar derivados de imidazol
ES8102561A1 (es) Procedimiento de preparacion de los aril-1 arilsulfonil-4 a amino-propoxi-3 1h pirazoles
ES8506017A1 (es) Procedimiento para preparar imidasoles
MY100900A (en) Substituted phenylsulfonyloxybenzimidazolecarbamates, processes for their preparation and their use as medicaments.
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
ES8308864A1 (es) Procedimiento para la fabricacion de nuevos derivados aminoalcoxi aromaticos.
JPS52136159A (en) Anti/malignanttumor containing the same as active ingredients
ES8504129A1 (es) Procedimiento para preparar derivados de 2(1h) piridona.
GB1409648A (en) Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof
ES8600758A1 (es) Procedimiento para preparar derivados de1,3-dioxolanilo
AU601583B2 (en) Protected cyclopantanols
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
JPS5352622A (en) Composition for preparation of bordeaux mixture
JPS5297389A (en) Removal of sulfate ion in extracted phosphoric acid
ES8308562A1 (es) Procedimiento para preparar 3',4',5'-trimetoxibenzoato de 1718-dehidorapovincaminol, util como agente activo en preparaciones farmaceuticas
ES8501359A1 (es) Un procedimiento para la produccion de compuestos poliprenilicos.
ES8105367A1 (es) Perfeccionamientos en o relacionados con compuestos organi- cos
ES8702134A1 (es) Sustancia para incrementar el ph de la dentina y procedi- miento para su fabricacion
ES8505665A1 (es) Procedimiento para preparar derivados acilaminofenolicos
DE3564423D1 (en) Purification of 4-fluoro-4'-hydroxy-benzophenone
ES8500619A1 (es) Procedimiento de preparacion de derivados de eburnano-oxima racemicos u opticamente activos.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303