FI832637A0 - Derivat av morfolinyl-daunorubicin och morfolinyldoxorubicin och analoger daerav samt foerfarande fframstaellning daerav - Google Patents

Derivat av morfolinyl-daunorubicin och morfolinyldoxorubicin och analoger daerav samt foerfarande fframstaellning daerav

Info

Publication number
FI832637A0
FI832637A0 FI832637A FI832637A FI832637A0 FI 832637 A0 FI832637 A0 FI 832637A0 FI 832637 A FI832637 A FI 832637A FI 832637 A FI832637 A FI 832637A FI 832637 A0 FI832637 A0 FI 832637A0
Authority
FI
Finland
Prior art keywords
och
daerav
morfolinyldoxorubicin
fframstaellning
morfolinyl
Prior art date
Application number
FI832637A
Other languages
English (en)
Other versions
FI75174C (fi
FI832637A (fi
FI75174B (fi
Inventor
Carol Walker Mosher
George Low Tong
Edward Mcintosh Acton
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of FI832637A0 publication Critical patent/FI832637A0/fi
Publication of FI832637A publication Critical patent/FI832637A/fi
Application granted granted Critical
Publication of FI75174B publication Critical patent/FI75174B/fi
Publication of FI75174C publication Critical patent/FI75174C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI832637A 1982-07-20 1983-07-19 Foerfarande foer framstaellning av morfolinyl-daunorubicin och morfolinyl-doxorubicin. FI75174C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40012082A 1982-07-20 1982-07-20
US40012082 1982-07-20
US06/496,122 US4464529A (en) 1982-07-20 1983-05-24 Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
US49612283 1983-05-24

Publications (4)

Publication Number Publication Date
FI832637A0 true FI832637A0 (fi) 1983-07-19
FI832637A FI832637A (fi) 1984-01-21
FI75174B FI75174B (fi) 1988-01-29
FI75174C FI75174C (fi) 1988-05-09

Family

ID=27016900

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832637A FI75174C (fi) 1982-07-20 1983-07-19 Foerfarande foer framstaellning av morfolinyl-daunorubicin och morfolinyl-doxorubicin.

Country Status (24)

Country Link
US (1) US4464529A (fi)
KR (1) KR880002461B1 (fi)
AT (1) AT381319B (fi)
AU (1) AU555902B2 (fi)
BE (1) BE897312A (fi)
CA (1) CA1239396A (fi)
CH (1) CH655729A5 (fi)
DE (1) DE3325816A1 (fi)
DK (1) DK158269C (fi)
ES (2) ES524271A0 (fi)
FI (1) FI75174C (fi)
FR (1) FR2530640B1 (fi)
GB (1) GB2124224B (fi)
GR (1) GR78885B (fi)
IE (1) IE55795B1 (fi)
IL (1) IL69260A (fi)
IT (1) IT1163818B (fi)
NL (1) NL188905C (fi)
NO (1) NO157146C (fi)
NZ (1) NZ204911A (fi)
PH (1) PH21860A (fi)
PT (1) PT77060B (fi)
SE (1) SE459921B (fi)
YU (2) YU155083A (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) * 1984-03-09 1987-01-16 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) * 1984-06-15 1988-01-15 Hoechst Lab Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4705850A (en) * 1984-10-25 1987-11-10 Sri International C-glycosidic adriamycin analogs
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
DE60031793T2 (de) * 1999-12-29 2007-08-23 Immunogen Inc., Cambridge Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
CN101555264B (zh) * 2008-04-11 2014-09-03 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
CA2803646A1 (en) 2010-07-02 2012-01-05 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
US10149913B2 (en) 2014-09-12 2018-12-11 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4202967A (en) * 1978-10-02 1980-05-13 Sri International N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) * 1981-03-23 1982-02-02 Sri International 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

Also Published As

Publication number Publication date
ES8501415A1 (es) 1984-11-16
PT77060A (en) 1983-08-01
ES530593A0 (es) 1985-11-01
CH655729A5 (de) 1986-05-15
AT381319B (de) 1986-09-25
AU1694683A (en) 1984-01-26
ES524271A0 (es) 1984-11-16
IE55795B1 (en) 1991-01-16
FR2530640B1 (fr) 1985-07-12
IT1163818B (it) 1987-04-08
YU140585A (en) 1986-02-28
GB2124224A (en) 1984-02-15
NO832610L (no) 1984-01-23
IT8322143A0 (it) 1983-07-20
NZ204911A (en) 1986-04-11
DK332983D0 (da) 1983-07-19
GR78885B (fi) 1984-10-02
DK158269C (da) 1990-10-08
PT77060B (en) 1986-04-09
DK332983A (da) 1984-01-21
FR2530640A1 (fr) 1984-01-27
ATA260883A (de) 1986-02-15
NO157146C (no) 1988-01-27
IL69260A (en) 1987-03-31
ES8602032A1 (es) 1985-11-01
IT8322143A1 (it) 1985-01-20
GB8319165D0 (en) 1983-08-17
PH21860A (en) 1988-03-25
FI75174C (fi) 1988-05-09
IE831680L (en) 1984-01-20
US4464529A (en) 1984-08-07
SE8304045L (sv) 1984-01-21
SE8304045D0 (sv) 1983-07-19
DE3325816A1 (de) 1984-01-26
BE897312A (fr) 1984-01-18
FI832637A (fi) 1984-01-21
KR880002461B1 (ko) 1988-11-14
AU555902B2 (en) 1986-10-16
YU155083A (en) 1986-02-28
NO157146B (no) 1987-10-19
GB2124224B (en) 1985-12-04
DK158269B (da) 1990-04-23
FI75174B (fi) 1988-01-29
NL8302586A (nl) 1984-02-16
SE459921B (sv) 1989-08-21
NL188905C (nl) 1992-11-02
IL69260A0 (en) 1983-11-30
CA1239396A (en) 1988-07-19
DE3325816C2 (fi) 1990-05-03
KR840005443A (ko) 1984-11-12

Similar Documents

Publication Publication Date Title
FI832637A0 (fi) Derivat av morfolinyl-daunorubicin och morfolinyldoxorubicin och analoger daerav samt foerfarande fframstaellning daerav
FI813038L (fi) Derivater av kefalosporin foerfarande av framstaellning av dessa och sammansaettningar innehaollande dessa
FI792000A (fi) Plastbag med flera vaeggar samt foerfarande och anordning foer framstaellande av densamma
FI820039L (fi) Baerlist av plastmaterial med u-formad tvaersektionsform och foer uppbaerning av roerledningar kablar etc
FI821533L (fi) Regleringssystem foer oevervakning och reglering av glasskivors hantering i glasbehandlingsutrymme
FI821074A0 (fi) Foeretraedesvis med bindemedel foerstaerkta haordmetallkroppar och foerfarande foer framstaellning av dessa
FI824249L (fi) Koppling foer styv foerbindning av koaxiala byggdelar och kopplingens anvaendning i kardanaxlar
FI821812A0 (fi) Foerfarande och apparat foer maetning av dryckkoncentrat
FI813037L (fi) Derivater av kefalosporin foerfarande av framstaellning av dessa och sammansaettningar innehaollande dessa
FI820727L (fi) Foerfarande foer formande av en flerskiktig pappersbana i en dubbelviragrupp och dubbelviragrupp foer utfoerande av foerfarandet
FI820748L (fi) I livmodern insaettbart preventivmedel och foerfarande foer framstaellning av detsamma
FI820957L (fi) Foerfarande foer tillvaratagande av monosackarider samt och anlaeggning foer genomfoerande av foerfarandet
FI830051L (fi) Foderblandning innehaollande ett lignosulfonatbaserat granuleringshjaelpmedel och med foerbaettradegranuleringsegenskaper samt anvaendning av granuleringshjaelpmedlet
FI802051A (fi) Foerfarande foer framstaellning av en blandning med en laongvarig bronkolytisk och tokolytisk verksamhet
FI833285A0 (fi) Foerfarande foer maetning av gasmaengder och foer dosering av foerutbestaemda vaetskemaengder samt anordningar foer utfoerande av dessa foerfaranden
FI65497B (fi) Maetapparatur foer bestaemning av taethet och fukthalt i korniga och fibroesa aemnen samt vaetskor
FI821655A0 (fi) Foerfarande och anordning foer el-uppvaermning av utrymmen
FI833115A0 (fi) Foerfarande foer framstaellning av blodtryckssaenkande i-substituerad- och cykliska lactam-2-karboxylsyror och deras derivat
FI810013L (fi) Foerfarande och anordning foer behandling av ytorna foer stycken utskurna fraon pressade ostblock
FI832532A0 (fi) Kopplingsfoerfarande foer snabbmagnetisering av en elmagnet med likstroemsmatning samt foer regleriav magnetisering och demagnetisering
FI821529L (fi) Foerfarande foer framstaellning av foensterkarmar och -baogar samt saolunda framstaellda karmar och
FI823595A0 (fi) Skiktprodukt laempad foer belaeggning av livsmedel samt foerfarande och blandning foer framstaellninprodukten
FI840400A0 (fi) Foerfarande och anordning foer palning av samt torvpackning
FI830902A0 (fi) Foer framstaellning av betong och betongmassa avsett bindemedel samt foerfarande foer framstaellnindaerav
FI833344A0 (fi) Buntnings- och bindningsfoerfarande foer papper och dylikt samt anordning foer genomfoerande av foerfarandet

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: SRI INTERNATIONAL