IL69260A - Derivatives and analogs of 3'-deamino-3'-(4-morpholinyl)-daunorubicin and 3'-deamino-3'-(4-morpholinyl)doxorubicin,their preparation and pharmaceutical compositions containing them - Google Patents

Derivatives and analogs of 3'-deamino-3'-(4-morpholinyl)-daunorubicin and 3'-deamino-3'-(4-morpholinyl)doxorubicin,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL69260A
IL69260A IL69260A IL6926083A IL69260A IL 69260 A IL69260 A IL 69260A IL 69260 A IL69260 A IL 69260A IL 6926083 A IL6926083 A IL 6926083A IL 69260 A IL69260 A IL 69260A
Authority
IL
Israel
Prior art keywords
deamino
morpholinyl
daunorubicin
doxorubicin
analogs
Prior art date
Application number
IL69260A
Other languages
English (en)
Other versions
IL69260A0 (en
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of IL69260A0 publication Critical patent/IL69260A0/xx
Publication of IL69260A publication Critical patent/IL69260A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL69260A 1982-07-20 1983-07-18 Derivatives and analogs of 3'-deamino-3'-(4-morpholinyl)-daunorubicin and 3'-deamino-3'-(4-morpholinyl)doxorubicin,their preparation and pharmaceutical compositions containing them IL69260A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40012082A 1982-07-20 1982-07-20
US06/496,122 US4464529A (en) 1982-07-20 1983-05-24 Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Publications (2)

Publication Number Publication Date
IL69260A0 IL69260A0 (en) 1983-11-30
IL69260A true IL69260A (en) 1987-03-31

Family

ID=27016900

Family Applications (1)

Application Number Title Priority Date Filing Date
IL69260A IL69260A (en) 1982-07-20 1983-07-18 Derivatives and analogs of 3'-deamino-3'-(4-morpholinyl)-daunorubicin and 3'-deamino-3'-(4-morpholinyl)doxorubicin,their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US4464529A (xx)
KR (1) KR880002461B1 (xx)
AT (1) AT381319B (xx)
AU (1) AU555902B2 (xx)
BE (1) BE897312A (xx)
CA (1) CA1239396A (xx)
CH (1) CH655729A5 (xx)
DE (1) DE3325816A1 (xx)
DK (1) DK158269C (xx)
ES (2) ES8501415A1 (xx)
FI (1) FI75174C (xx)
FR (1) FR2530640B1 (xx)
GB (1) GB2124224B (xx)
GR (1) GR78885B (xx)
IE (1) IE55795B1 (xx)
IL (1) IL69260A (xx)
IT (1) IT1163818B (xx)
NL (1) NL188905C (xx)
NO (1) NO157146C (xx)
NZ (1) NZ204911A (xx)
PH (1) PH21860A (xx)
PT (1) PT77060B (xx)
SE (1) SE459921B (xx)
YU (2) YU155083A (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) * 1984-03-09 1987-01-16 Hoechst Lab Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) * 1984-06-15 1988-01-15 Hoechst Lab Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4705850A (en) * 1984-10-25 1987-11-10 Sri International C-glycosidic adriamycin analogs
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
WO2001049698A1 (en) * 1999-12-29 2001-07-12 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
CA2721140C (en) * 2008-04-11 2016-02-09 Tianjin Hemay Bio-Tech Co. Ltd. Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
EP3191134B1 (en) 2014-09-12 2019-11-20 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4202967A (en) * 1978-10-02 1980-05-13 Sri International N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) * 1981-03-23 1982-02-02 Sri International 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

Also Published As

Publication number Publication date
ES524271A0 (es) 1984-11-16
SE8304045L (sv) 1984-01-21
IT8322143A1 (it) 1985-01-20
DE3325816A1 (de) 1984-01-26
YU140585A (en) 1986-02-28
GR78885B (xx) 1984-10-02
AT381319B (de) 1986-09-25
AU1694683A (en) 1984-01-26
IE55795B1 (en) 1991-01-16
KR880002461B1 (ko) 1988-11-14
DK332983A (da) 1984-01-21
NZ204911A (en) 1986-04-11
IT8322143A0 (it) 1983-07-20
IE831680L (en) 1984-01-20
NO832610L (no) 1984-01-23
ES8501415A1 (es) 1984-11-16
US4464529A (en) 1984-08-07
BE897312A (fr) 1984-01-18
NO157146C (no) 1988-01-27
GB2124224A (en) 1984-02-15
CH655729A5 (de) 1986-05-15
PT77060A (en) 1983-08-01
YU155083A (en) 1986-02-28
FI75174B (fi) 1988-01-29
DE3325816C2 (xx) 1990-05-03
PH21860A (en) 1988-03-25
ES8602032A1 (es) 1985-11-01
CA1239396A (en) 1988-07-19
GB2124224B (en) 1985-12-04
KR840005443A (ko) 1984-11-12
SE8304045D0 (sv) 1983-07-19
FI75174C (fi) 1988-05-09
IL69260A0 (en) 1983-11-30
ES530593A0 (es) 1985-11-01
DK332983D0 (da) 1983-07-19
ATA260883A (de) 1986-02-15
GB8319165D0 (en) 1983-08-17
SE459921B (sv) 1989-08-21
AU555902B2 (en) 1986-10-16
PT77060B (en) 1986-04-09
DK158269C (da) 1990-10-08
FR2530640A1 (fr) 1984-01-27
IT1163818B (it) 1987-04-08
FI832637A0 (fi) 1983-07-19
FR2530640B1 (fr) 1985-07-12
NO157146B (no) 1987-10-19
NL188905C (nl) 1992-11-02
DK158269B (da) 1990-04-23
NL8302586A (nl) 1984-02-16
FI832637A (fi) 1984-01-21

Similar Documents

Publication Publication Date Title
IL69260A (en) Derivatives and analogs of 3'-deamino-3'-(4-morpholinyl)-daunorubicin and 3'-deamino-3'-(4-morpholinyl)doxorubicin,their preparation and pharmaceutical compositions containing them
IL71569A0 (en) Phenethanolamine derivatives,their preparation and pharmaceutical compositions containing them
IL69955A (en) 1-phenyl-2-piperidinoalkanol derivatives,their preparation and pharmaceutical compositions containing them
IL68913A (en) 3-aminoalkyl-1h-indole-5-alkan-sulphonamide derivatives,their preparation and pharmaceutical compositions containing them
IL73706A0 (en) 2,2'-iminobisethanol derivatives,their preparation and pharmaceutical compositions containing them
IL69157A0 (en) Fluoromorphinan derivatives,their preparation and pharmaceutical compositions containing them
IL92054A0 (en) Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof,their preparation and pharmaceutical compositions containing them
IL68360A0 (en) Imidazopyrazolopyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL67618A0 (en) Phenylethylene derivatives,their preparation and pharmaceutical compositions containing them
IL68817A0 (en) Oxoazetidine derivatives,their preparation and pharmaceutical compositions containing them
IL65858A (en) 4-demethoxy-6(11)-deoxy-doxorubicin and daunorubicin derivatives,their preparation and pharmaceutical compositions containing them
DE3377212D1 (en) New substituted derivatives of 2,5-diamino 1,4-diazole, preparation methods thereof and pharmaceutical compositions containing them
IL68496A (en) 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them
DE3380093D1 (en) 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL70508A (en) Pharmaceutical compositions containing aralkyltriazole derivatives,some such novel compounds and their preparation
IL70359A (en) Phenothiazine derivatives,their preparation and pharmaceutical compositions containing them
IL75485A (en) Ethanolamine compounds,their preparation and pharmaceutical compositions containing them
IL74264A (en) Preparation of calciferol derivatives,certain such novel compounds and pharmaceutical compositions containing them
IL68720A (en) 3'-deamino analogs of anthracycline glycoside antibiotics,their preparation and pharmaceutical compositions containing them
IL73964A0 (en) 1,4-naphthoquinone derivatives,their preparation and pharmaceutical compositions containing them
IL69848A0 (en) 15-cycloaliphatic derivatives of 11,14-didehydrocarboprostacyclins,their preparation and pharmaceutical compositions containing them
IL70401A0 (en) Ethenediamine and guanidine derivatives,their preparation and pharmaceutical compositions containing them
DE3469176D1 (en) 2,6-dioxopiperidine derivatives, their preparation and pharmaceutical compositions containing them
IL67709A0 (en) Daunorubicin and doxorubicin analogues,their preparation and pharmaceutical compositions containing them
IL69274A (en) (substituted amino)derivatives of 3-benzylidene-pyrrolo(2,1-b)quinazolin-9-ones and 6-benzylidene-pyrido(2,1-b)quinazolin-11-ones,their preparation and pharmaceutical compositions containing them