FI832637A - Derivat av morfolinyl-daunorubicin och morfolinyldoxorubicin och analoger daerav samt foerfarande fframstaellning daerav - Google Patents
Derivat av morfolinyl-daunorubicin och morfolinyldoxorubicin och analoger daerav samt foerfarande fframstaellning daerav Download PDFInfo
- Publication number
- FI832637A FI832637A FI832637A FI832637A FI832637A FI 832637 A FI832637 A FI 832637A FI 832637 A FI832637 A FI 832637A FI 832637 A FI832637 A FI 832637A FI 832637 A FI832637 A FI 832637A
- Authority
- FI
- Finland
- Prior art keywords
- och
- daerav
- morfolinyldoxorubicin
- fframstaellning
- morfolinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40012082A | 1982-07-20 | 1982-07-20 | |
US40012082 | 1982-07-20 | ||
US49612283 | 1983-05-24 | ||
US06/496,122 US4464529A (en) | 1982-07-20 | 1983-05-24 | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
Publications (4)
Publication Number | Publication Date |
---|---|
FI832637A0 FI832637A0 (fi) | 1983-07-19 |
FI832637A true FI832637A (fi) | 1984-01-21 |
FI75174B FI75174B (fi) | 1988-01-29 |
FI75174C FI75174C (fi) | 1988-05-09 |
Family
ID=27016900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI832637A FI75174C (fi) | 1982-07-20 | 1983-07-19 | Foerfarande foer framstaellning av morfolinyl-daunorubicin och morfolinyl-doxorubicin. |
Country Status (24)
Country | Link |
---|---|
US (1) | US4464529A (fi) |
KR (1) | KR880002461B1 (fi) |
AT (1) | AT381319B (fi) |
AU (1) | AU555902B2 (fi) |
BE (1) | BE897312A (fi) |
CA (1) | CA1239396A (fi) |
CH (1) | CH655729A5 (fi) |
DE (1) | DE3325816A1 (fi) |
DK (1) | DK158269C (fi) |
ES (2) | ES8501415A1 (fi) |
FI (1) | FI75174C (fi) |
FR (1) | FR2530640B1 (fi) |
GB (1) | GB2124224B (fi) |
GR (1) | GR78885B (fi) |
IE (1) | IE55795B1 (fi) |
IL (1) | IL69260A (fi) |
IT (1) | IT1163818B (fi) |
NL (1) | NL188905C (fi) |
NO (1) | NO157146C (fi) |
NZ (1) | NZ204911A (fi) |
PH (1) | PH21860A (fi) |
PT (1) | PT77060B (fi) |
SE (1) | SE459921B (fi) |
YU (2) | YU155083A (fi) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826964A (en) * | 1982-07-20 | 1989-05-02 | Sri International | Bridged oxygen analogs of daunorubcin and doxorubicin |
JPS59212499A (ja) * | 1983-05-13 | 1984-12-01 | アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド | 抗腫瘍性抗生物質アントラサイクリンの4−デメトキシ−3′−デアミノ−3′(4−モリホリニル)誘導体 |
GB2140006A (en) * | 1983-05-17 | 1984-11-21 | Erba Farmitalia | Anthracycline derivatives |
US4585859A (en) * | 1983-05-24 | 1986-04-29 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
FR2560876B1 (fr) * | 1984-03-09 | 1987-01-16 | Hoechst Lab | Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments |
FR2565982B1 (fr) * | 1984-06-15 | 1988-01-15 | Hoechst Lab | Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals |
GB8426672D0 (en) * | 1984-10-22 | 1984-11-28 | Erba Farmitalia | Pharmaceutical compositions |
US4705850A (en) * | 1984-10-25 | 1987-11-10 | Sri International | C-glycosidic adriamycin analogs |
US4591637A (en) * | 1985-01-17 | 1986-05-27 | Sri International | Open chain-morpholino adriamycins |
US4710564A (en) * | 1985-01-18 | 1987-12-01 | Microbial Chemistry Research Foundation | Anthracycline compounds |
GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
GB9019933D0 (en) * | 1990-09-12 | 1990-10-24 | Erba Carlo Spa | 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines |
US5196522A (en) * | 1990-11-01 | 1993-03-23 | Board Of Regents, The University Of Texas System | Anthracycline analogues bearing latent alkylating substituents |
US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
AU767394C (en) * | 1999-12-29 | 2005-04-21 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
WO2005086951A2 (en) * | 2004-03-10 | 2005-09-22 | Threshold Pharmaceuticals, Inc. | Hypoxia-activated anti-cancer agents |
US20070060534A1 (en) * | 2005-06-30 | 2007-03-15 | Threshold Pharmaceuticals, Inc. | Anthracycline analogs |
WO2009124468A1 (zh) * | 2008-04-11 | 2009-10-15 | 天津和美生物技术有限公司 | 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用 |
BR112012033295A2 (pt) | 2010-07-02 | 2016-10-11 | Angiochem Inc | polipeptídeos curtos e contendo d-aminoácido para conjugados terapêuticos e seu uso |
EP3191134B1 (en) | 2014-09-12 | 2019-11-20 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
EP4180061A1 (en) | 2021-11-10 | 2023-05-17 | Nerviano Medical Sciences S.r.l. | Anthracycline derivative linker reagents, antibody-drug conjugates and methods |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4109076A (en) * | 1977-09-08 | 1978-08-22 | Sri International | 5-iminodaunomycin |
US4202967A (en) * | 1978-10-02 | 1980-05-13 | Sri International | N,N-pentamethylene derivatives of daunomycin and adriamycin |
US4301277A (en) * | 1980-10-20 | 1981-11-17 | Sri International | 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin |
US4314054A (en) * | 1981-03-23 | 1982-02-02 | Sri International | 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin |
-
1983
- 1983-05-24 US US06/496,122 patent/US4464529A/en not_active Expired - Lifetime
- 1983-07-15 GB GB08319165A patent/GB2124224B/en not_active Expired
- 1983-07-15 AT AT0260883A patent/AT381319B/de not_active IP Right Cessation
- 1983-07-15 NZ NZ204911A patent/NZ204911A/en unknown
- 1983-07-18 NO NO832610A patent/NO157146C/no unknown
- 1983-07-18 DE DE19833325816 patent/DE3325816A1/de active Granted
- 1983-07-18 BE BE0/211190A patent/BE897312A/fr not_active IP Right Cessation
- 1983-07-18 IL IL69260A patent/IL69260A/xx unknown
- 1983-07-18 YU YU01550/83A patent/YU155083A/xx unknown
- 1983-07-18 AU AU16946/83A patent/AU555902B2/en not_active Ceased
- 1983-07-18 FR FR8311803A patent/FR2530640B1/fr not_active Expired
- 1983-07-18 PH PH29236A patent/PH21860A/en unknown
- 1983-07-19 PT PT77060A patent/PT77060B/pt not_active IP Right Cessation
- 1983-07-19 DK DK332983A patent/DK158269C/da not_active IP Right Cessation
- 1983-07-19 KR KR1019830003323A patent/KR880002461B1/ko not_active IP Right Cessation
- 1983-07-19 SE SE8304045A patent/SE459921B/sv not_active IP Right Cessation
- 1983-07-19 IE IE1680/83A patent/IE55795B1/en not_active IP Right Cessation
- 1983-07-19 CH CH3949/83A patent/CH655729A5/de not_active IP Right Cessation
- 1983-07-19 CA CA000432737A patent/CA1239396A/en not_active Expired
- 1983-07-19 NL NLAANVRAGE8302586,A patent/NL188905C/xx not_active IP Right Cessation
- 1983-07-19 ES ES524271A patent/ES8501415A1/es not_active Expired
- 1983-07-19 GR GR71976A patent/GR78885B/el unknown
- 1983-07-19 FI FI832637A patent/FI75174C/fi not_active IP Right Cessation
- 1983-07-20 IT IT22143/83A patent/IT1163818B/it active
-
1984
- 1984-03-14 ES ES530593A patent/ES530593A0/es active Granted
-
1985
- 1985-09-09 YU YU01405/85A patent/YU140585A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI832637A (fi) | Derivat av morfolinyl-daunorubicin och morfolinyldoxorubicin och analoger daerav samt foerfarande fframstaellning daerav | |
FI813038L (fi) | Derivater av kefalosporin foerfarande av framstaellning av dessa och sammansaettningar innehaollande dessa | |
FI792000A (fi) | Plastbag med flera vaeggar samt foerfarande och anordning foer framstaellande av densamma | |
FI820039L (fi) | Baerlist av plastmaterial med u-formad tvaersektionsform och foer uppbaerning av roerledningar kablar etc | |
FI821533L (fi) | Regleringssystem foer oevervakning och reglering av glasskivors hantering i glasbehandlingsutrymme | |
FI821074L (fi) | Foeretraedesvis med bindemedel foerstaerkta haordmetallkroppar och foerfarande foer framstaellning av dessa | |
FI824249L (fi) | Koppling foer styv foerbindning av koaxiala byggdelar och kopplingens anvaendning i kardanaxlar | |
FI821812A0 (fi) | Foerfarande och apparat foer maetning av dryckkoncentrat | |
FI813037L (fi) | Derivater av kefalosporin foerfarande av framstaellning av dessa och sammansaettningar innehaollande dessa | |
FI820727L (fi) | Foerfarande foer formande av en flerskiktig pappersbana i en dubbelviragrupp och dubbelviragrupp foer utfoerande av foerfarandet | |
FI820748L (fi) | I livmodern insaettbart preventivmedel och foerfarande foer framstaellning av detsamma | |
FI820957L (fi) | Foerfarande foer tillvaratagande av monosackarider samt och anlaeggning foer genomfoerande av foerfarandet | |
FI830051L (fi) | Foderblandning innehaollande ett lignosulfonatbaserat granuleringshjaelpmedel och med foerbaettradegranuleringsegenskaper samt anvaendning av granuleringshjaelpmedlet | |
FI802051A (fi) | Foerfarande foer framstaellning av en blandning med en laongvarig bronkolytisk och tokolytisk verksamhet | |
FI833285A (fi) | Foerfarande foer maetning av gasmaengder och foer dosering av foerutbestaemda vaetskemaengder samt anordningar foer utfoerande av dessa foerfaranden | |
FI65497B (fi) | Maetapparatur foer bestaemning av taethet och fukthalt i korniga och fibroesa aemnen samt vaetskor | |
FI821655A0 (fi) | Foerfarande och anordning foer el-uppvaermning av utrymmen | |
FI833115A0 (fi) | Foerfarande foer framstaellning av blodtryckssaenkande i-substituerad- och cykliska lactam-2-karboxylsyror och deras derivat | |
FI810013L (fi) | Foerfarande och anordning foer behandling av ytorna foer stycken utskurna fraon pressade ostblock | |
FI832532A0 (fi) | Kopplingsfoerfarande foer snabbmagnetisering av en elmagnet med likstroemsmatning samt foer regleriav magnetisering och demagnetisering | |
FI823595L (fi) | Skiktprodukt laempad foer belaeggning av livsmedel samt foerfarande och blandning foer framstaellniprodukten | |
FI821529L (fi) | Foerfarande foer framstaellning av foensterkarmar och -baogar samt saolunda framstaellda karmar och | |
FI840400A0 (fi) | Foerfarande och anordning foer palning av samt torvpackning | |
FI831246A0 (fi) | Foerfarande foer lastning och lossning av stockar samt anordning foer detsamma | |
FI830902A0 (fi) | Foer framstaellning av betong och betongmassa avsett bindemedel samt foerfarande foer framstaellnindaerav |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: SRI INTERNATIONAL |