CN101274926A - β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物 - Google Patents

β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物 Download PDF

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Publication number
CN101274926A
CN101274926A CNA2008100013400A CN200810001340A CN101274926A CN 101274926 A CN101274926 A CN 101274926A CN A2008100013400 A CNA2008100013400 A CN A2008100013400A CN 200810001340 A CN200810001340 A CN 200810001340A CN 101274926 A CN101274926 A CN 101274926A
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CN
China
Prior art keywords
fluoro
thiophene
sulphonamide
chloro
methylol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2008100013400A
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English (en)
Chinese (zh)
Inventor
A·F·克雷夫特
L·雷斯尼克
S·C·迈尔
G·迪亚曼蒂迪斯
D·C·科尔
王听中
R·J·加兰特
M·霍克
B·L·哈里森
张民生
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Wyeth LLC
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Wyeth LLC
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Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of CN101274926A publication Critical patent/CN101274926A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2008100013400A 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物 Pending CN101274926A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
US60/459228 2003-03-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2004800087813A Division CN1780829B (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物

Publications (1)

Publication Number Publication Date
CN101274926A true CN101274926A (zh) 2008-10-01

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ID=33299665

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2004800087813A Expired - Fee Related CN1780829B (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
CNA2008100013400A Pending CN101274926A (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物

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CN2004800087813A Expired - Fee Related CN1780829B (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物

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US (3) US7300951B2 (US07858658-20101228-C00033.png)
EP (1) EP1608638A1 (US07858658-20101228-C00033.png)
JP (1) JP2006522126A (US07858658-20101228-C00033.png)
KR (1) KR20060002908A (US07858658-20101228-C00033.png)
CN (2) CN1780829B (US07858658-20101228-C00033.png)
AR (1) AR043940A1 (US07858658-20101228-C00033.png)
AU (1) AU2004230844B2 (US07858658-20101228-C00033.png)
BR (1) BRPI0408962A (US07858658-20101228-C00033.png)
CA (1) CA2517155A1 (US07858658-20101228-C00033.png)
CL (1) CL2004000647A1 (US07858658-20101228-C00033.png)
CO (1) CO5640049A2 (US07858658-20101228-C00033.png)
CR (1) CR7951A (US07858658-20101228-C00033.png)
EC (1) ECSP056128A (US07858658-20101228-C00033.png)
MX (1) MXPA05010368A (US07858658-20101228-C00033.png)
NO (1) NO20054263L (US07858658-20101228-C00033.png)
NZ (1) NZ542468A (US07858658-20101228-C00033.png)
RU (1) RU2342374C2 (US07858658-20101228-C00033.png)
SG (1) SG167669A1 (US07858658-20101228-C00033.png)
TW (1) TWI336698B (US07858658-20101228-C00033.png)
UA (1) UA82093C2 (US07858658-20101228-C00033.png)
WO (1) WO2004092155A1 (US07858658-20101228-C00033.png)
ZA (1) ZA200507896B (US07858658-20101228-C00033.png)

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US20090227667A1 (en) 2009-09-10
US7300951B2 (en) 2007-11-27
US7547725B2 (en) 2009-06-16
ECSP056128A (es) 2006-03-01
UA82093C2 (uk) 2008-03-11
KR20060002908A (ko) 2006-01-09
WO2004092155A1 (en) 2004-10-28
TW200504047A (en) 2005-02-01
SG167669A1 (en) 2011-01-28
CN1780829B (zh) 2010-12-29
TWI336698B (en) 2011-02-01
US20040198778A1 (en) 2004-10-07
CR7951A (es) 2008-10-29
US7858658B2 (en) 2010-12-28
RU2342374C2 (ru) 2008-12-27
JP2006522126A (ja) 2006-09-28
MXPA05010368A (es) 2005-11-17
AR043940A1 (es) 2005-08-17
AU2004230844A1 (en) 2004-10-28
BRPI0408962A (pt) 2006-04-04
ZA200507896B (en) 2007-03-28
US20070254929A1 (en) 2007-11-01
AU2004230844B2 (en) 2010-12-09
NZ542468A (en) 2009-01-31
CL2004000647A1 (es) 2005-02-04
CN1780829A (zh) 2006-05-31
NO20054263L (no) 2005-12-14
RU2005133434A (ru) 2006-07-10
CA2517155A1 (en) 2004-10-28
NO20054263D0 (no) 2005-09-15
CO5640049A2 (es) 2006-05-31
EP1608638A1 (en) 2005-12-28

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