CR7951A - Inhibidores de fluor y trifluoroalquilo que contienen heterociclicos de la produccion beta amiloide derivados y de los mismos - Google Patents

Inhibidores de fluor y trifluoroalquilo que contienen heterociclicos de la produccion beta amiloide derivados y de los mismos

Info

Publication number
CR7951A
CR7951A CR7951A CR7951A CR7951A CR 7951 A CR7951 A CR 7951A CR 7951 A CR7951 A CR 7951A CR 7951 A CR7951 A CR 7951A CR 7951 A CR7951 A CR 7951A
Authority
CR
Costa Rica
Prior art keywords
trifluoroalquilo
heterociclicos
amiloide
fluor
inhibitors
Prior art date
Application number
CR7951A
Other languages
English (en)
Inventor
Antohny Kreft Frank
Resnick Lynn
Scott Mayer Christian
Diamantidis George
Dereck Cole Cecil
Wang Tingzhong
Hoke Molly
Boyd Harrison Lynn
Zhang Minsheng
John Galante Rocco
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR7951A publication Critical patent/CR7951A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Abstract

La presente invencion se refiere a compuestos de Formula (I), en donde T es CHO, COR8, o C(OH) R1R2; R1 y R2 son hidrogeno, opcionalmente alquilo inferior sustituido, CF3, opcionalmente alquenilo sustituido, o alquinilo opcionalmente sustituido; R3 es hidrogeno o alquilo inferior opcionalmente sustituido; R4 es (CF3)nalquilo (fenilo sustituido), o (F)ncicloalquilo; n=1-3; R5 es hidrogeno, halogeno, CF3, dieno fusionado a Y cuando Y=C, o dieno fusionado a Y cuando Y=C; W, Y y Z son C, CR6 o N, en donde al menos uno de W, Y o Z son C; R6 es hidrogeno, halogeno o alquilo inferior opcionalmente sustituido.
CR7951A 2003-03-31 2005-08-19 Inhibidores de fluor y trifluoroalquilo que contienen heterociclicos de la produccion beta amiloide derivados y de los mismos CR7951A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31

Publications (1)

Publication Number Publication Date
CR7951A true CR7951A (es) 2008-10-29

Family

ID=33299665

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7951A CR7951A (es) 2003-03-31 2005-08-19 Inhibidores de fluor y trifluoroalquilo que contienen heterociclicos de la produccion beta amiloide derivados y de los mismos

Country Status (22)

Country Link
US (3) US7300951B2 (es)
EP (1) EP1608638A1 (es)
JP (1) JP2006522126A (es)
KR (1) KR20060002908A (es)
CN (2) CN1780829B (es)
AR (1) AR043940A1 (es)
AU (1) AU2004230844B2 (es)
BR (1) BRPI0408962A (es)
CA (1) CA2517155A1 (es)
CL (1) CL2004000647A1 (es)
CO (1) CO5640049A2 (es)
CR (1) CR7951A (es)
EC (1) ECSP056128A (es)
MX (1) MXPA05010368A (es)
NO (1) NO20054263L (es)
NZ (1) NZ542468A (es)
RU (1) RU2342374C2 (es)
SG (1) SG167669A1 (es)
TW (1) TWI336698B (es)
UA (1) UA82093C2 (es)
WO (1) WO2004092155A1 (es)
ZA (1) ZA200507896B (es)

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WO2010126002A1 (ja) * 2009-04-28 2010-11-04 塩野義製薬株式会社 ヘテロ環スルホンアミド化合物を含有する医薬
WO2011084503A1 (en) * 2009-12-16 2011-07-14 North Carolina Central University Phenoxy thiophene sulfonamides and their use in the treatment of neurodegenerative diseases
US9223209B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing photoresist compositions and methods of use
US9223217B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
US9617239B2 (en) 2010-03-10 2017-04-11 North Carolina Central University Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
JP2015527398A (ja) 2012-09-07 2015-09-17 マサチューセッツ アイ アンド イヤー インファーマリー 聴覚喪失治療
JP6319912B2 (ja) 2013-04-19 2018-05-09 国立大学法人 岡山大学 アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
KR102362222B1 (ko) 2016-05-16 2022-02-11 더 제너럴 하스피탈 코포레이션 폐 상피 공학에서 인간 기도 줄기 세포
WO2019148067A1 (en) 2018-01-26 2019-08-01 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
EP4299062A1 (en) 2022-06-30 2024-01-03 Vilnius University Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides

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CA2552558A1 (en) * 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
JP2009528281A (ja) * 2006-02-17 2009-08-06 ワイス スルホンアミド置換アルコールおよびその中間体の調製方法
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BRPI0710470A2 (pt) * 2006-04-21 2011-08-16 Wyeth Corp métodos para preparar seletivamente um aminoálcool quiral e uma sulfonamida quiral
US7476762B2 (en) * 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
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Also Published As

Publication number Publication date
NZ542468A (en) 2009-01-31
BRPI0408962A (pt) 2006-04-04
EP1608638A1 (en) 2005-12-28
KR20060002908A (ko) 2006-01-09
US7547725B2 (en) 2009-06-16
AU2004230844A1 (en) 2004-10-28
NO20054263L (no) 2005-12-14
TW200504047A (en) 2005-02-01
US20040198778A1 (en) 2004-10-07
RU2342374C2 (ru) 2008-12-27
AU2004230844B2 (en) 2010-12-09
CN1780829A (zh) 2006-05-31
TWI336698B (en) 2011-02-01
WO2004092155A1 (en) 2004-10-28
AR043940A1 (es) 2005-08-17
JP2006522126A (ja) 2006-09-28
CL2004000647A1 (es) 2005-02-04
CN101274926A (zh) 2008-10-01
US7300951B2 (en) 2007-11-27
UA82093C2 (uk) 2008-03-11
US20070254929A1 (en) 2007-11-01
RU2005133434A (ru) 2006-07-10
CN1780829B (zh) 2010-12-29
ZA200507896B (en) 2007-03-28
ECSP056128A (es) 2006-03-01
CA2517155A1 (en) 2004-10-28
US7858658B2 (en) 2010-12-28
MXPA05010368A (es) 2005-11-17
US20090227667A1 (en) 2009-09-10
NO20054263D0 (no) 2005-09-15
CO5640049A2 (es) 2006-05-31
SG167669A1 (en) 2011-01-28

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