NO20054263L - Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav - Google Patents

Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav

Info

Publication number
NO20054263L
NO20054263L NO20054263A NO20054263A NO20054263L NO 20054263 L NO20054263 L NO 20054263L NO 20054263 A NO20054263 A NO 20054263A NO 20054263 A NO20054263 A NO 20054263A NO 20054263 L NO20054263 L NO 20054263L
Authority
NO
Norway
Prior art keywords
optionally substituted
hydrogen
lower alkyl
beta amyloid
trifluoroalkyl
Prior art date
Application number
NO20054263A
Other languages
English (en)
Other versions
NO20054263D0 (no
Inventor
Boyd Lynn Harrison
Derek Cecil Cole
Minsheng Zhang
Anthony Frank Kreft
Scott Christian Mayer
Lynn Resnick
George Diamantidis
Tingzhong Wang
Rocco Galante
Molly Hoke
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20054263D0 publication Critical patent/NO20054263D0/no
Publication of NO20054263L publication Critical patent/NO20054263L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med Formel (I) blir fremskaffet der T er CHO, COR8 eller C(OH)R1R2, R1 og R2 er hydrogen, eventuelt substituert lavere alkyl, CF3, eventuelt substituert alkenyl eller eventuelt substituert alkynyl, R3 er hydrogen eller eventuelt substituert lavere alkyl, R4 er (CF3)nalkyl, (CF3)n(substituert alkyl), (CF3)nalkylfenyl, (CF3)nalkyl(substituert fenyl) eller (F)ncykloalkyl, n=1-3, R5 er hydrogen, halogen, CF3, dien fusjonert til Y når Y=C eller substituert dien fusjonert til Y når Y=C, W, Y og Z er C, CR6 eller N der minst en av W, Y eller Z er C, R6 er hydrogen, halogen eller eventuelt substituert lavere alkyl, X er O, S, SO2 eller NR7, R7 er hydrogen, eventuelt substituert lavere alkyl, eventuelt substituert benzyl eller eventuelt substituert fenyl, og R8 er lavere alkyl, CF3 eller eventuelt substituert fenyl. Fremgangsmåter for fremstilling og anvendelse av disse forbindelsene for hemming av betaamyloidproduksjon og for behandling av Alzheimers sykdom og Downs syndrom er også beskrevet
NO20054263A 2003-03-31 2005-09-15 Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav NO20054263L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
PCT/US2004/009268 WO2004092155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Publications (2)

Publication Number Publication Date
NO20054263D0 NO20054263D0 (no) 2005-09-15
NO20054263L true NO20054263L (no) 2005-12-14

Family

ID=33299665

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054263A NO20054263L (no) 2003-03-31 2005-09-15 Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav

Country Status (22)

Country Link
US (3) US7300951B2 (no)
EP (1) EP1608638A1 (no)
JP (1) JP2006522126A (no)
KR (1) KR20060002908A (no)
CN (2) CN1780829B (no)
AR (1) AR043940A1 (no)
AU (1) AU2004230844B2 (no)
BR (1) BRPI0408962A (no)
CA (1) CA2517155A1 (no)
CL (1) CL2004000647A1 (no)
CO (1) CO5640049A2 (no)
CR (1) CR7951A (no)
EC (1) ECSP056128A (no)
MX (1) MXPA05010368A (no)
NO (1) NO20054263L (no)
NZ (1) NZ542468A (no)
RU (1) RU2342374C2 (no)
SG (1) SG167669A1 (no)
TW (1) TWI336698B (no)
UA (1) UA82093C2 (no)
WO (1) WO2004092155A1 (no)
ZA (1) ZA200507896B (no)

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Also Published As

Publication number Publication date
US20090227667A1 (en) 2009-09-10
US7300951B2 (en) 2007-11-27
US7547725B2 (en) 2009-06-16
ECSP056128A (es) 2006-03-01
UA82093C2 (uk) 2008-03-11
KR20060002908A (ko) 2006-01-09
WO2004092155A1 (en) 2004-10-28
TW200504047A (en) 2005-02-01
CN101274926A (zh) 2008-10-01
SG167669A1 (en) 2011-01-28
CN1780829B (zh) 2010-12-29
TWI336698B (en) 2011-02-01
US20040198778A1 (en) 2004-10-07
CR7951A (es) 2008-10-29
US7858658B2 (en) 2010-12-28
RU2342374C2 (ru) 2008-12-27
JP2006522126A (ja) 2006-09-28
MXPA05010368A (es) 2005-11-17
AR043940A1 (es) 2005-08-17
AU2004230844A1 (en) 2004-10-28
BRPI0408962A (pt) 2006-04-04
ZA200507896B (en) 2007-03-28
US20070254929A1 (en) 2007-11-01
AU2004230844B2 (en) 2010-12-09
NZ542468A (en) 2009-01-31
CL2004000647A1 (es) 2005-02-04
CN1780829A (zh) 2006-05-31
RU2005133434A (ru) 2006-07-10
CA2517155A1 (en) 2004-10-28
NO20054263D0 (no) 2005-09-15
CO5640049A2 (es) 2006-05-31
EP1608638A1 (en) 2005-12-28

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