ECSP056128A - Fluoro y trifluoroalquil que contienen inhibidores de producción de beta amiloide de sulfonamida heterociclico y derivados del mismo - Google Patents

Fluoro y trifluoroalquil que contienen inhibidores de producción de beta amiloide de sulfonamida heterociclico y derivados del mismo

Info

Publication number
ECSP056128A
ECSP056128A EC2005006128A ECSP056128A ECSP056128A EC SP056128 A ECSP056128 A EC SP056128A EC 2005006128 A EC2005006128 A EC 2005006128A EC SP056128 A ECSP056128 A EC SP056128A EC SP056128 A ECSP056128 A EC SP056128A
Authority
EC
Ecuador
Prior art keywords
group
substitute
low alkyl
hydrogen
phenyl
Prior art date
Application number
EC2005006128A
Other languages
English (en)
Inventor
Derek Cecil Cole
Anthony Frank Kreft
Lynn Resnick
Scott Christian Mayer
George Diamantidis
Tingzhong Wang
Rocco John Galante
Molly Hoke
Boyd Lynn Harrison
Minsheng Zhang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP056128A publication Critical patent/ECSP056128A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Abstract

Compuestos de Fórmula (I), En donde: T es seleccionada del grupo consistente de CHO, COR8 y C(OH)R1R2; R1 R2 son independientemente seleccionadas de un grupo consistente de hidrogeno, alquil bajo, sustituto de alquil bajo, CF3, alquenil, alquenil sustituto, alquinil, y alquinil sustituto; R3 es seleccionado de un grupo consistente de hidrogeno, alquil bajo y sustituto de alquil bajo: R4 es seleccionado de un grupo consistente de (CF3)n alquil, (CF3)n (susituto de alquil), (CF3) alquil (sustituto de fenil), Y (F)n cicloalquil; n = 1-3; R5 es seleccionado de un grupo consistente de hidrogeno, halógeno, CF3, dieno fusionado a Y cuando Y=C, y dieno sustituído fusionado cuando Y=C; W, Y y Z son independientemente seleccionados de un grupo consistente de C, CR6, y N con la provisión de que por lo menos W o Y o Z debe ser C; R6 es seleccionado de un grupo consistente de hidrogeno, halógeno, alquil bajo y sustitutos de alquil bajo; X es seleccionado de un grupo consistente de O, S, SO2 y NR7; R7 es seleccionado de un grupo consistente de hidrogeno, alquil bajo, sustituto de alquil bajo, benzil, sustituto de benzil, fenil, sustituto de fenil; y R8 es seleccionado de un grupo consistente de alquil bajo, CF3, fenil y sustituto de fenil. Métodos de preparación y usos de estos compuestos inhibidores de producción beta amiloide, para el tratamiento de enfermedad de Alzheimer y Síndrome de Down.
EC2005006128A 2003-03-31 2005-10-28 Fluoro y trifluoroalquil que contienen inhibidores de producción de beta amiloide de sulfonamida heterociclico y derivados del mismo ECSP056128A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31

Publications (1)

Publication Number Publication Date
ECSP056128A true ECSP056128A (es) 2006-03-01

Family

ID=33299665

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006128A ECSP056128A (es) 2003-03-31 2005-10-28 Fluoro y trifluoroalquil que contienen inhibidores de producción de beta amiloide de sulfonamida heterociclico y derivados del mismo

Country Status (22)

Country Link
US (3) US7300951B2 (es)
EP (1) EP1608638A1 (es)
JP (1) JP2006522126A (es)
KR (1) KR20060002908A (es)
CN (2) CN1780829B (es)
AR (1) AR043940A1 (es)
AU (1) AU2004230844B2 (es)
BR (1) BRPI0408962A (es)
CA (1) CA2517155A1 (es)
CL (1) CL2004000647A1 (es)
CO (1) CO5640049A2 (es)
CR (1) CR7951A (es)
EC (1) ECSP056128A (es)
MX (1) MXPA05010368A (es)
NO (1) NO20054263L (es)
NZ (1) NZ542468A (es)
RU (1) RU2342374C2 (es)
SG (1) SG167669A1 (es)
TW (1) TWI336698B (es)
UA (1) UA82093C2 (es)
WO (1) WO2004092155A1 (es)
ZA (1) ZA200507896B (es)

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WO2011084503A1 (en) * 2009-12-16 2011-07-14 North Carolina Central University Phenoxy thiophene sulfonamides and their use in the treatment of neurodegenerative diseases
US9223209B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing photoresist compositions and methods of use
US9223217B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
US9617239B2 (en) 2010-03-10 2017-04-11 North Carolina Central University Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
JP2015527398A (ja) 2012-09-07 2015-09-17 マサチューセッツ アイ アンド イヤー インファーマリー 聴覚喪失治療
JP6319912B2 (ja) 2013-04-19 2018-05-09 国立大学法人 岡山大学 アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
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BRPI0710470A2 (pt) * 2006-04-21 2011-08-16 Wyeth Corp métodos para preparar seletivamente um aminoálcool quiral e uma sulfonamida quiral
US7476762B2 (en) * 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
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Also Published As

Publication number Publication date
NZ542468A (en) 2009-01-31
BRPI0408962A (pt) 2006-04-04
CR7951A (es) 2008-10-29
EP1608638A1 (en) 2005-12-28
KR20060002908A (ko) 2006-01-09
US7547725B2 (en) 2009-06-16
AU2004230844A1 (en) 2004-10-28
NO20054263L (no) 2005-12-14
TW200504047A (en) 2005-02-01
US20040198778A1 (en) 2004-10-07
RU2342374C2 (ru) 2008-12-27
AU2004230844B2 (en) 2010-12-09
CN1780829A (zh) 2006-05-31
TWI336698B (en) 2011-02-01
WO2004092155A1 (en) 2004-10-28
AR043940A1 (es) 2005-08-17
JP2006522126A (ja) 2006-09-28
CL2004000647A1 (es) 2005-02-04
CN101274926A (zh) 2008-10-01
US7300951B2 (en) 2007-11-27
UA82093C2 (uk) 2008-03-11
US20070254929A1 (en) 2007-11-01
RU2005133434A (ru) 2006-07-10
CN1780829B (zh) 2010-12-29
ZA200507896B (en) 2007-03-28
CA2517155A1 (en) 2004-10-28
US7858658B2 (en) 2010-12-28
MXPA05010368A (es) 2005-11-17
US20090227667A1 (en) 2009-09-10
NO20054263D0 (no) 2005-09-15
CO5640049A2 (es) 2006-05-31
SG167669A1 (en) 2011-01-28

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