BRPI0408962A - inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados - Google Patents

inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados

Info

Publication number
BRPI0408962A
BRPI0408962A BRPI0408962-6A BRPI0408962A BRPI0408962A BR PI0408962 A BRPI0408962 A BR PI0408962A BR PI0408962 A BRPI0408962 A BR PI0408962A BR PI0408962 A BRPI0408962 A BR PI0408962A
Authority
BR
Brazil
Prior art keywords
optionally substituted
hydrogen
lower alkyl
production
alkyl
Prior art date
Application number
BRPI0408962-6A
Other languages
English (en)
Inventor
Anthony Frank Kreft
Lynn Resnick
Scott Christian Mayer
George Diamantidis
Derek Cecil Cole
Tingzhong Wang
Rocco John Galante
Molly Hoke
Boyd Lynn Harrison
Minsheng Zhang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0408962A publication Critical patent/BRPI0408962A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"INIBIDORES SULFONAMIDAS HETEROCìCLICOS CONTENDO FLúOR- E TRIFLUOROALQUILA DA PRODUçãO DE BETA AMILóIDE E SEUS DERIVADOS". Compostos de fórmula (I) São fornecidos onde T é CHO, COR~ 8~ ou C(OH)R~ 1~R~ 2~, R~ 1~ e R~ 2~ são hidrogênio, alquila inferior opcionalmente substituída, CF~ 3~, alquenila opcionalmente substituída ou alquinila opcionalmente substituída; R~ 3~ é hidrogênio ou alquila inferior opcionalmente substituída; R~ 4~ é (CF~ 3~)~ n~alquila, (CF~ 3~)~ n~(alquila substituída), (CF~ 3~)~ n~alquiifenila,(CF~ 3~)~ n~alquila-(fenila substituída), ou (F)~ n~cicloalquila; n = 1 a 3; R~ 5~ é hidrogênio, halogeno, CF~ 3~, dieno fundido a Y quando Y = C, ou dieno substituído fundido a Y quando Y = C; W, Y e Z são C, CR~ 6~ ou N onde pelo menos um de W, Y ou Z é C; R~ 6~ é hidrogênio, halogeno ou alquila inferior opcionalmente substituída; X é O, S, SO~ 2~ ou NR~ 7~; R~ 7~ é hidrogênio, alquila inferior opcionalmente substituída, benzila opcionalmente substituída ou fenila opcionalmente substituída; e R~ 8~ é alquila inferior, CF~ 3~ ou fenila opcionalmente substítuida. Métodos de preparação e uso destes compostos para a inibição da produção de beta amilóide e para o tratamento de Doença de Alzheimer e síndrome de Down são também descritos; ou um sal, hidrato ou pró-medicamento farmaceuticamente aceitáveis destes.
BRPI0408962-6A 2003-03-31 2004-03-26 inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados BRPI0408962A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
PCT/US2004/009268 WO2004092155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Publications (1)

Publication Number Publication Date
BRPI0408962A true BRPI0408962A (pt) 2006-04-04

Family

ID=33299665

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408962-6A BRPI0408962A (pt) 2003-03-31 2004-03-26 inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados

Country Status (22)

Country Link
US (3) US7300951B2 (pt)
EP (1) EP1608638A1 (pt)
JP (1) JP2006522126A (pt)
KR (1) KR20060002908A (pt)
CN (2) CN1780829B (pt)
AR (1) AR043940A1 (pt)
AU (1) AU2004230844B2 (pt)
BR (1) BRPI0408962A (pt)
CA (1) CA2517155A1 (pt)
CL (1) CL2004000647A1 (pt)
CO (1) CO5640049A2 (pt)
CR (1) CR7951A (pt)
EC (1) ECSP056128A (pt)
MX (1) MXPA05010368A (pt)
NO (1) NO20054263L (pt)
NZ (1) NZ542468A (pt)
RU (1) RU2342374C2 (pt)
SG (1) SG167669A1 (pt)
TW (1) TWI336698B (pt)
UA (1) UA82093C2 (pt)
WO (1) WO2004092155A1 (pt)
ZA (1) ZA200507896B (pt)

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Also Published As

Publication number Publication date
US20090227667A1 (en) 2009-09-10
US7300951B2 (en) 2007-11-27
US7547725B2 (en) 2009-06-16
ECSP056128A (es) 2006-03-01
UA82093C2 (uk) 2008-03-11
KR20060002908A (ko) 2006-01-09
WO2004092155A1 (en) 2004-10-28
TW200504047A (en) 2005-02-01
CN101274926A (zh) 2008-10-01
SG167669A1 (en) 2011-01-28
CN1780829B (zh) 2010-12-29
TWI336698B (en) 2011-02-01
US20040198778A1 (en) 2004-10-07
CR7951A (es) 2008-10-29
US7858658B2 (en) 2010-12-28
RU2342374C2 (ru) 2008-12-27
JP2006522126A (ja) 2006-09-28
MXPA05010368A (es) 2005-11-17
AR043940A1 (es) 2005-08-17
AU2004230844A1 (en) 2004-10-28
ZA200507896B (en) 2007-03-28
US20070254929A1 (en) 2007-11-01
AU2004230844B2 (en) 2010-12-09
NZ542468A (en) 2009-01-31
CL2004000647A1 (es) 2005-02-04
CN1780829A (zh) 2006-05-31
NO20054263L (no) 2005-12-14
RU2005133434A (ru) 2006-07-10
CA2517155A1 (en) 2004-10-28
NO20054263D0 (no) 2005-09-15
CO5640049A2 (es) 2006-05-31
EP1608638A1 (en) 2005-12-28

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