CY1110237T1 - Συνθεση οιστετρολης δια στεροειδων προερχομενων απο οιστρονη - Google Patents

Συνθεση οιστετρολης δια στεροειδων προερχομενων απο οιστρονη

Info

Publication number
CY1110237T1
CY1110237T1 CY101100679T CY101100679T CY1110237T1 CY 1110237 T1 CY1110237 T1 CY 1110237T1 CY 101100679 T CY101100679 T CY 101100679T CY 101100679 T CY101100679 T CY 101100679T CY 1110237 T1 CY1110237 T1 CY 1110237T1
Authority
CY
Cyprus
Prior art keywords
ostroone
ostetrol
steroids
composition
group
Prior art date
Application number
CY101100679T
Other languages
English (en)
Inventor
Mark Theodoor Verhaar
Thomas Koch
Erwin Gerardus Jacobus Warmerdam
Original Assignee
Pantarhei Bioscience B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pantarhei Bioscience B.V. filed Critical Pantarhei Bioscience B.V.
Publication of CY1110237T1 publication Critical patent/CY1110237T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)

Abstract

Παρέχεται μια μέθοδος για την παρασκευή οιστετρόλης ξεκινώντας από μια 3-Α-οξυ-οιστρα-1,3,5 (10),15-τετραεν-17-όνη, όπου το Α είναι μια C1-C5 αλκυλο-ομάδα, κατά προτίμηση μια μεθυλο-ομάδα, ή μια C7-C12 βενζυλική ομάδα, κατά προτίμηση μια βενζυλο-ομάδα. Η εν λόγω μέθοδος ενδεικνυται ιδιαιτέρως για τη βιομηχανία.
CY101100679T 2002-11-08 2010-07-20 Συνθεση οιστετρολης δια στεροειδων προερχομενων απο οιστρονη CY1110237T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02079676 2002-11-08
EP20030772962 EP1562976B1 (en) 2002-11-08 2003-11-07 Synthesis of estetrol via estrone derived steroids

Publications (1)

Publication Number Publication Date
CY1110237T1 true CY1110237T1 (el) 2015-01-14

Family

ID=32309415

Family Applications (1)

Application Number Title Priority Date Filing Date
CY101100679T CY1110237T1 (el) 2002-11-08 2010-07-20 Συνθεση οιστετρολης δια στεροειδων προερχομενων απο οιστρονη

Country Status (13)

Country Link
US (3) US20060211669A1 (el)
EP (1) EP1562976B1 (el)
CN (1) CN100343269C (el)
AT (1) ATE469165T1 (el)
AU (1) AU2003279624A1 (el)
CA (1) CA2505190C (el)
CY (1) CY1110237T1 (el)
DE (1) DE60332754D1 (el)
DK (1) DK1562976T3 (el)
ES (1) ES2346053T3 (el)
PT (1) PT1562976E (el)
SI (1) SI1562976T1 (el)
WO (1) WO2004041839A2 (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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MX342537B (es) * 2011-06-01 2016-10-04 Estetra Sprl Proceso para la produccion de intermediarios de estetrol.
MX341561B (es) 2011-06-01 2016-08-25 Estetra Sprl Proceso para la produccion de intermediarios de estetrol.
EP2383279A1 (en) * 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
EA028780B1 (ru) 2011-08-11 2017-12-29 Эстетра С.П.Р.Л. Применение эстетрола в качестве экстренного контрацептива
HUE028963T2 (en) 2011-10-07 2017-01-30 Estetra Sprl Process for the preparation of estetrol
WO2013034780A2 (en) 2012-12-20 2013-03-14 Crystal Pharma, S.A.U. Process for the preparation of estetrol and related compounds
CA2924255C (en) 2013-09-18 2022-11-22 Crystal Pharma, S.A.U. Process for the preparation of estetrol
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
WO2016203009A1 (en) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
NO3106148T3 (el) 2015-06-18 2018-08-11
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
ES2906380T3 (es) * 2017-08-01 2022-04-18 Fund Sa Terapia adyuvante para usar en el tratamiento del cáncer de próstata
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
HU231240B1 (hu) * 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
IT201900021879A1 (it) 2019-11-22 2021-05-22 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
IT201900017414A1 (it) 2019-09-27 2021-03-27 Ind Chimica Srl Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
MX2022003688A (es) 2019-09-27 2022-04-26 Ind Chimica Srl Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trien o-3,15,16,17-tetrol (estetrol) e intermedios de dicho proceso.
IT202100019631A1 (it) 2021-07-23 2023-01-23 Newchem S P A Metodo per produrre estetrolo e i suoi intermedi
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol
CN118251402A (zh) 2021-10-01 2024-06-25 工业化学有限公司 制备(15α,16α,17β)-雌甾-1,3,5(10)-三烯-3,15,16,17-四醇（雌四醇）一水合物的方法
WO2023209017A1 (en) 2022-04-26 2023-11-02 Mithra R&D Sa Process for the production of estetrol intermediates

Family Cites Families (18)

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US3138588A (en) * 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3177206A (en) * 1963-03-07 1965-04-06 American Home Prod Selective bromination of a-ring aromatic 17-ketalized steroids
US3433785A (en) * 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3673180A (en) * 1970-06-18 1972-06-27 Merck & Co Inc 19-nor-6,6-ethylene-20-spiroxenes
DD144266A1 (de) * 1979-06-13 1980-10-08 Helmut Kasch Verfahren zur herstellung von delta hoch 15-17-ketosteroiden der oestran-und androstanreihe
US4739078A (en) * 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
US5340586A (en) * 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) * 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
WO2002094276A1 (en) 2001-05-18 2002-11-28 Pantarhei Bioscience B.V. Pharmaceutical composition for use in hormone replacement therapy
WO2002094278A1 (en) 2001-05-23 2002-11-28 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
CA2448278C (en) 2001-05-23 2010-06-08 Christian Franz Holinka Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
ES2278925T3 (es) 2001-11-15 2007-08-16 Pantarhei Bioscience B.V. Uso de compuestos estrogenicos en combinacion con compuestos progestogenicos en terapias de sustitucion hormonal.
EP2204445B1 (de) 2005-07-25 2013-01-02 RiboxX GmbH Verfahren und Kit zur primer-abhängigen Amplifikation heterologer viraler, eukaryontischer oder prokaryontischer RNA
GB0621926D0 (en) 2006-11-03 2006-12-13 Medlock Medical Ltd Multi directional stretch tubular bandages
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition

Also Published As

Publication number Publication date
ATE469165T1 (de) 2010-06-15
WO2004041839A3 (en) 2004-07-01
EP1562976B1 (en) 2010-05-26
WO2004041839A2 (en) 2004-05-21
PT1562976E (pt) 2010-08-12
EP1562976A2 (en) 2005-08-17
US10000524B2 (en) 2018-06-19
CN1735627A (zh) 2006-02-15
US20060211669A1 (en) 2006-09-21
US20180265540A1 (en) 2018-09-20
US20150105362A1 (en) 2015-04-16
WO2004041839A8 (en) 2005-07-21
ES2346053T3 (es) 2010-10-08
DE60332754D1 (de) 2010-07-08
CN100343269C (zh) 2007-10-17
CA2505190A1 (en) 2004-05-21
AU2003279624A1 (en) 2004-06-07
DK1562976T3 (da) 2010-08-16
CA2505190C (en) 2012-07-10
SI1562976T1 (sl) 2010-08-31

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