DE60332754D1 - Synthese von oestetrol aus von oestron abgeleiteten steroiden - Google Patents

Synthese von oestetrol aus von oestron abgeleiteten steroiden

Info

Publication number
DE60332754D1
DE60332754D1 DE60332754T DE60332754T DE60332754D1 DE 60332754 D1 DE60332754 D1 DE 60332754D1 DE 60332754 T DE60332754 T DE 60332754T DE 60332754 T DE60332754 T DE 60332754T DE 60332754 D1 DE60332754 D1 DE 60332754D1
Authority
DE
Germany
Prior art keywords
oestron
oestetrol
synthesis
derived steroids
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60332754T
Other languages
English (en)
Inventor
Mark Theodoor Verhaar
Thomas Koch
Erwin Gerardus Warmerdam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pantarhei Bioscience BV
Original Assignee
Pantarhei Bioscience BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pantarhei Bioscience BV filed Critical Pantarhei Bioscience BV
Application granted granted Critical
Publication of DE60332754D1 publication Critical patent/DE60332754D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
DE60332754T 2002-11-08 2003-11-07 Synthese von oestetrol aus von oestron abgeleiteten steroiden Expired - Lifetime DE60332754D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02079676 2002-11-08
PCT/NL2003/000782 WO2004041839A2 (en) 2002-11-08 2003-11-07 Synthesis of estetrol via estrone derived steroids

Publications (1)

Publication Number Publication Date
DE60332754D1 true DE60332754D1 (de) 2010-07-08

Family

ID=32309415

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60332754T Expired - Lifetime DE60332754D1 (de) 2002-11-08 2003-11-07 Synthese von oestetrol aus von oestron abgeleiteten steroiden

Country Status (13)

Country Link
US (3) US20060211669A1 (de)
EP (1) EP1562976B1 (de)
CN (1) CN100343269C (de)
AT (1) ATE469165T1 (de)
AU (1) AU2003279624A1 (de)
CA (1) CA2505190C (de)
CY (1) CY1110237T1 (de)
DE (1) DE60332754D1 (de)
DK (1) DK1562976T3 (de)
ES (1) ES2346053T3 (de)
PT (1) PT1562976E (de)
SI (1) SI1562976T1 (de)
WO (1) WO2004041839A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA025511B1 (ru) 2011-06-01 2016-12-30 Эстетра С.П.Р.Л. Способ получения промежуточных соединений эстетрола
CN107266514A (zh) * 2011-06-01 2017-10-20 埃斯特拉私人有限责任公司 用于产生雌四醇中间体的方法
EP2383279A1 (de) * 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Herstellungsverfahren für Esterol
PT2741824T (pt) * 2011-08-11 2017-07-06 Estetra Sprl Utilização de estetrol como contracetivo de emergência
US8987484B2 (en) * 2011-10-07 2015-03-24 Estetra S.P.R.L. Process for the production of estetrol
WO2013034780A2 (en) 2012-12-20 2013-03-14 Crystal Pharma, S.A.U. Process for the preparation of estetrol and related compounds
JP6254289B2 (ja) * 2013-09-18 2017-12-27 クリスタル ファルマ、エセ、ア、ウＣｒｙｓｔａｌ Ｐｈａｒｍａ，Ｓ．Ａ．Ｕ． エステトロールの製造プロセス
UA123098C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент
EA035687B1 (ru) 2015-06-18 2020-07-27 Эстетра Спрл Диспергируемая в полости рта единица дозирования, содержащая эстетрольный компонент
EP3310346B1 (de) 2015-06-18 2021-03-24 Estetra SPRL Orodispersible tablette enthaltend estetrol
DK3310345T3 (da) 2015-06-18 2021-05-25 Estetra Sprl Orodispersibel tablet indeholdende estetrol
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
BR112020002094A2 (pt) * 2017-08-01 2020-07-28 Fund Sa terapia adjuvante para o uso em tratamento de câncer de próstata
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
HU231240B1 (hu) 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
IT201900021879A1 (it) 2019-11-22 2021-05-22 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
IT201900017414A1 (it) 2019-09-27 2021-03-27 Ind Chimica Srl Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
FR3101348B1 (fr) * 2019-09-27 2024-01-19 Ind Chimica Srl PROCÉDÉ DE PRÉPARATION DE (15α,16α,17β)-OESTRA-1,3,5(10)-TRIÈNE-3,15,16,17-TÉTROL (OESTÉTROL) ET INTERMÉDIAIRES DUDIT PROCÉDÉ
IT202100019631A1 (it) 2021-07-23 2023-01-23 Newchem S P A Metodo per produrre estetrolo e i suoi intermedi
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol
GB2626482A (en) 2021-10-01 2024-07-24 Ind Chimica Srl Process for preparing (15alpha,16alpha,17eta)-estra-1,3,5-(10)-triene-3,15,16,17-tetrol(estetrol) monohydrate
AR129146A1 (es) 2022-04-26 2024-07-24 Mithra R&D Sa Proceso para la producción de intermediarios de estetrol
WO2024160373A1 (en) 2023-02-02 2024-08-08 Industriale Chimica S.R.L. PROCESS FOR PREPARING (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRATE

Family Cites Families (18)

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US3138588A (en) * 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3177206A (en) * 1963-03-07 1965-04-06 American Home Prod Selective bromination of a-ring aromatic 17-ketalized steroids
US3433785A (en) * 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3673180A (en) * 1970-06-18 1972-06-27 Merck & Co Inc 19-nor-6,6-ethylene-20-spiroxenes
DD144266A1 (de) * 1979-06-13 1980-10-08 Helmut Kasch Verfahren zur herstellung von delta hoch 15-17-ketosteroiden der oestran-und androstanreihe
US4739078A (en) * 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
US5340586A (en) * 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) * 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
EP1260225A1 (de) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. Pharmazeutische Zusammensetzung für die Hormonersatztherapie
US8048869B2 (en) 2001-05-18 2011-11-01 Pantarhei Bioscience B.V. Pharmaceutical composition for use in hormone replacement therapy
PT1390042E (pt) 2001-05-23 2008-03-10 Pantarhei Bioscience Bv Sistema de administração de um medicamento que compreende estrogénio tetrahidroxilado destinado à contracepção hormonal
ATE449606T1 (de) 2001-05-23 2009-12-15 Pantarhei Bioscience Bv Tetrahydroxylierte estrogen enthaltendes arzneistoffverabreichungssystem zur verwendung in hormonalen kontrazeption
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
WO2003041718A1 (en) 2001-11-15 2003-05-22 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
CN101228268A (zh) 2005-07-25 2008-07-23 德累斯顿工业大学 Rna扩增和/或rna标记用的rna依赖的rna聚合酶，方法及试剂盒
GB0621926D0 (en) 2006-11-03 2006-12-13 Medlock Medical Ltd Multi directional stretch tubular bandages
EP2077272A1 (de) 2007-12-21 2009-07-08 Affibody AB Polypeptid-Bibliothek mit vorbestimmtem Gerüst
EP2077273B1 (de) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Verfahren zur Trennung von Casein aus löslichen Proteinen in einer Zusammensetzung

Also Published As

Publication number Publication date
WO2004041839A2 (en) 2004-05-21
US10000524B2 (en) 2018-06-19
AU2003279624A1 (en) 2004-06-07
EP1562976B1 (de) 2010-05-26
CN1735627A (zh) 2006-02-15
PT1562976E (pt) 2010-08-12
CA2505190C (en) 2012-07-10
US20060211669A1 (en) 2006-09-21
ATE469165T1 (de) 2010-06-15
CA2505190A1 (en) 2004-05-21
ES2346053T3 (es) 2010-10-08
SI1562976T1 (sl) 2010-08-31
EP1562976A2 (de) 2005-08-17
US20180265540A1 (en) 2018-09-20
CN100343269C (zh) 2007-10-17
WO2004041839A3 (en) 2004-07-01
US20150105362A1 (en) 2015-04-16
DK1562976T3 (da) 2010-08-16
WO2004041839A8 (en) 2005-07-21
CY1110237T1 (el) 2015-01-14

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Legal Events

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