CN110719902A - Ssao抑制剂 - Google Patents

Ssao抑制剂 Download PDF

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CN110719902A
CN110719902A CN201880037601.6A CN201880037601A CN110719902A CN 110719902 A CN110719902 A CN 110719902A CN 201880037601 A CN201880037601 A CN 201880037601A CN 110719902 A CN110719902 A CN 110719902A
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compound
synthesis
pharmaceutically acceptable
nmr
400mhz
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CN110719902B (zh
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罗志
李小林
杨亚讯
杨乐乐
李鹏
贺海鹰
黎健
陈曙辉
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Shandong Danhong Pharmaceutical Co Ltd
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Shandong Danhong Pharmaceutical Co Ltd
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

本发公开了一类SSAO抑制剂，及其在制备治疗与SSAO关疾病的药物中的应用。具体公开了式(Ⅳ)所示化合物及其药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201880037601.6A 2017-06-20 2018-06-20 Ssao抑制剂 Active CN110719902B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN2017104701678 2017-06-20
CN201710470167 2017-06-20
CN2017106610175 2017-08-04
CN201710661017 2017-08-04
CN201711229457X 2017-11-29
CN201711229457 2017-11-29
CN2018105825954 2018-06-07
CN201810582595 2018-06-07
PCT/CN2018/092003 WO2018233633A1 (zh) 2017-06-20 2018-06-20 Ssao 抑制剂

Publications (2)

Publication Number Publication Date
CN110719902A true CN110719902A (zh) 2020-01-21
CN110719902B CN110719902B (zh) 2022-08-12

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CN201880037601.6A Active CN110719902B (zh) 2017-06-20 2018-06-20 Ssao抑制剂

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US (2) US11001563B2 (zh)
EP (1) EP3626699B1 (zh)
JP (1) JP6861858B2 (zh)
KR (1) KR102187608B1 (zh)
CN (1) CN110719902B (zh)
AU (1) AU2018287777B2 (zh)
ES (1) ES2965404T3 (zh)
FI (1) FI3626699T3 (zh)
PT (1) PT3626699T (zh)
WO (1) WO2018233633A1 (zh)

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Publication number Priority date Publication date Assignee Title
WO2018233633A1 (zh) * 2017-06-20 2018-12-27 南京明德新药研发股份有限公司 Ssao 抑制剂
KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
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