CN101087621A - 具有身体脂肪减少功能的组合物以及含该组合物的食物和饮料 - Google Patents
具有身体脂肪减少功能的组合物以及含该组合物的食物和饮料 Download PDFInfo
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- CN101087621A CN101087621A CNA2005800388622A CN200580038862A CN101087621A CN 101087621 A CN101087621 A CN 101087621A CN A2005800388622 A CNA2005800388622 A CN A2005800388622A CN 200580038862 A CN200580038862 A CN 200580038862A CN 101087621 A CN101087621 A CN 101087621A
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- 230000035488 systolic blood pressure Effects 0.000 description 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
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Images
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Abstract
Description
g/100ml | 对照咖啡 | MOS咖啡 |
咖啡固形物人造甜味料MOS玉米糖浆固形物 | 1.10.017--1.0 | 1.10.0171.0-- |
受验者数量 | 组别 | 总计 | 男 | 女 |
对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS | 151455.7±2.849.6±2.9157.2±2.1160.3±2.366.9±1.869.2±2.027.0±0.226.9±0.436.2±0.136.0±0.186.3±1.286.5±1.596.8±1.097.8±0.91.8±0.11.7±0.12.3±0.22.3±0.1127.5±4.4131.8±3.379.9±2.382.4±2.369.3±2.267.8±1.6 | 7753.1±14.146.0±11.5163.2±5.8167.5±1.871.8±6.374.5±3.926.9±0.826.6±1.436.3±0.336.1±0.489.1±2.688.6±4.296.1±3.397.3±2.31.4±0.41.4±0.12.7±1.12.3±0.3128.1±15.6132.9±11.881.6±9.784.3±8.667.1±6.967.7±6.6 | 8757.9±7.253.1±9.8151.9±5.7153.2±5.862.5±4.863.9±6.527.1±1.027.1±1.436.1±0.535.8±0.483.8±4.784.4±6.197.4±4.298.2±4.12.1±0.32.0±0.22.0±0.32.3±0.3127.0±19.4130.7±13.678.4±8.680.4±9.971.3±9.867.9±5.6 | |
年龄岁身高cm体重KgBMIkg/m2体温℃腰围cm臀围cm臂皮下脂肪厚度cm肩胛下皮下脂肪厚度cmSBPammHgSBPbmmHg脉博次/分钟 |
0周 | 4周 | 8周 | 12周 | ||
体重(kg)BMI(kg/m2)腰围(cm)臀围(cm)臂皮下脂肪厚度(cm)肩胛下皮下脂肪厚度(cm) | 对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS | 66.9±1.869.2±2.027.0±0.226.9±0.486.3±1.286.5±1.596.8±1.097.8±0.91.8±0.11.7±0.12.3±0.22.3±0.1 | 66.3±1.868.8±1.926.8±0.326.7±0.385.6±1.3*86.0±1.496.4±1.0*97.6±0.91.8±0.11.7±0.12.4±0.22.3±0.1 | 66.5±1.968.6±2.026.9±0.326.6±0.485.1±1.2**85.1±1.696.5±1.096.4±1.21.8±0.11.8±0.12.4±0.22.3±0.1 | 66.3±1.968.7±2.026.8±0.326.7±0.385.1±1.4*84.8±1.5*96.2±1.196.1±1.21.8±0.11.7±0.12.3±0.22.2±0.1* |
0周 | 4周 | 8周 | 12周 | 重复测量的ANOVA的P值(试验期间) | ||
总脂肪面积(cm2) | 对照△(自0周)MOS△(自0周) | 274.5±11281.5±19.1 | 263±12.5-11.3±7.1266.3±19.8-15.2±7.7 | 261±11.6-13.8±6.8251.0±21.6**-30.5±4.4 | 265.5±11.1-8.9±6.1248.9±19.2**-32.6±5.4 | 0.00003 |
皮下脂肪面积(cm2) | 对照△(自0周)MOS△(自0周) | 181.6±12.3±173.4±15.1± | 169.8±13.0-11.7±5.7166.1±15.1-7.3±4.4 | 171.4±12.5*-10.1±4.3156.7±15.7**-16.8±3.7 | 174.6±13.1-7.0±6.0154.5±14.8**-18.9±3.3 | 0.00024 |
内脏脂肪面积(cm2) | 对照△(自0周)MOS△(自0周) | 92.9±8.4±108±11± | 93.1±6.60.4±4.4100±10.8-7.9±5.2 | 89.2±8.3-3.7±494.4±11.3**-13.7±2.9 | 91.0±9.7-9.0±6.194.4±11.9**-13.7±3.9 | 0.01928 |
正常范围 | 单位 | 组 | 0周 | 4周 | 8周 | 12周 | |
白细胞红细胞血红蛋白血细胞比容MCVMCHMCHC血小板 | 3500-9700M438-577F376-516M13.6-18.3F11.2-15.2M40.4-51.9F34.3-45.2M83-101F80-101M28.2-4.7F26.4-34.3M31.8-36.4F31.3-36.114.0-37.9 | /μL×104/μLg/100ml%fLpg%×104/μL | 对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS | 6553±10156748±1721464.9±40.5486.6±32.314.17±1.5214.92±0.9544.29±4.3945.94±2.9295.3±3.794.4±3.530.47±1.3730.69±0.8432.01±1.4732.50±0.9124.32±4.4323.02±4.85 | 6544±11566490±1608468.5±42.6487.4±31.114.29±1.6514.82±0.9044.61±4.6946.31±2.5595.2±3.095.0±3.430.46±1.3130.45±0.9632.02±0.7132.01±1.0125.09±5.4123.85±4.54 | 6313±14836415±1658457.1±40.4*475.1±34.1*14.00±1.4814.70±0.96*43.31±4.60**45.19±2.6894.7±3.995.2±2.630.61±1.2830.95±0.7432.35±0.5132.53±0.5823.32±3.9922.58±4.82 | 6303±12796872±1279460.9±38.6475.3±38.6**14.12±1.4514.58±1.45**43.59±4.15*44.81±4.15*94.6±3.394.4±3.330.62±1.1930.67±1.1932.38±0.7932.54±0.7924.53±4.8723.56±4.87 |
正常范围 | 单位 | 组 | 0周 | 4周 | 8周 | 12周 | |
总蛋白A/G比率白蛋白总胆红素AST(GOT)ALT(GPT)ALPLDHγ-GTPT-胆固醇HDL-ChoLDL-Cho甘油三酯 | 6.5-8.21.30-2.003.7-5.50.2-1.010-405-45104-338120-145M16-73(F8-32)150-219M40-80F40-9070-13950-149 | g/100ml-g/100mlmg/100mlU/lU/lU/lU/lU/lmg/100mlmg/100mlmg/100mlmg/100ml | 对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS对照MOS | 7.48±0.097.53±0.091.45±0.191.51±0.184.41±0.244.50±0.190.79±0.220.72±0.2025.9±9.922.8±10.228.1±16.728.3±17.8238.7±64.4214.3±55.5205.5±25.5206.3±50.737.2±27.138.7±21.7236.9±28.2223.2±30.352.8±11.756.6±13.3163.1±30.3151.3±26.0127.5±56.6105.9±52.5 | 7.46±0.337.51±0.191.43±0.161.44±0.154.38±0.244.42±0.240.71±0.210.67±0.1825.0±9.220.4±7.028.1±19.025.2±9.7245.9±75.6223.3±52.8210.3±29.0201.6±41.239.9±28.936.2±20.2235.3±22.8233.3±32.752.5±13.255.0±13.6151.3±26.5152.2±23.8153.0±100.3139.0±77.5 | 7.33±0.35**7.53±0.261.45±0.161.4S±0.174.33±0.22*4.44±0.290.74±0.240.74±0.2225.0±8.222.5±7.625.5±11.425.8±13.2228.4±65.3209.2±52.6215.1±25.4*210.6±43.635.6±23.232.1±15.1*233.9±30.2219.4±30.652.5±12.756.1±13.1157.4±28.5146.4±28.7146.8±70.0119.3±52.2 | 7.34±0.28**7.40±0.281.49±0.161.48±0.164.37±0.144.41±0.14*0.79±0.250.81±0.2524.6±7.023.3±7.028.1±11.728.0±11.7228.5±64.2208.1±64.2202.2±23.8196.6±23.8*41.9±30.639.0±30.6243.5±26.6224.5±26.651.3±13.754.7±13.7156.8±23.0141.8±23.0*142.3±84.9113.2±84.9 |
摄入周期 | 0周 | 4周 | 8周 | 12周 |
体重(Kg) | 68.8±8.1 | 68.0±7.5 | 67.9±2.2* | 67.8±2.2* |
身体脂肪比率(%) | 35.4±4.5 | 33.7±4.5** | 32.3±1.3* | 33.8±1.1* |
BMI | 27.8±0.7 | 27.5±0.8 | 27.5±0.3* | 27.4±0.3□ |
0周 | 第2周 | 第4周 | |
体重 kg身体脂肪比率 %BMI | 59.5±12.224.2±4.324.4±2.9 | 58.9±12.0*23.8±4.822.2±2.9* | 59.1±12.2*23.4±4.6*22.2±3.0* |
Claims (31)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004271412A JP4488852B2 (ja) | 2004-09-17 | 2004-09-17 | 体内脂肪低減作用を有する組成物 |
JP271412/2004 | 2004-09-17 | ||
PCT/US2005/012823 WO2006036208A1 (en) | 2004-09-17 | 2005-04-14 | Compositions having body fat reducing function and food and drink containing the same |
Publications (2)
Publication Number | Publication Date |
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CN101087621A true CN101087621A (zh) | 2007-12-12 |
CN101087621B CN101087621B (zh) | 2013-01-02 |
Family
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CN2005800388622A Expired - Fee Related CN101087621B (zh) | 2004-09-17 | 2005-04-14 | 具有身体脂肪减少功能的组合物以及含该组合物的食物和饮料 |
Country Status (17)
Country | Link |
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US (1) | US20080213425A1 (zh) |
EP (1) | EP1809328B1 (zh) |
JP (1) | JP4488852B2 (zh) |
KR (1) | KR101203778B1 (zh) |
CN (1) | CN101087621B (zh) |
AU (1) | AU2005290262B2 (zh) |
BR (1) | BRPI0515411A (zh) |
CA (1) | CA2580652C (zh) |
DK (1) | DK1809328T3 (zh) |
ES (1) | ES2404694T3 (zh) |
IL (1) | IL181858A0 (zh) |
PL (1) | PL1809328T3 (zh) |
PT (1) | PT1809328E (zh) |
RU (1) | RU2358741C2 (zh) |
SI (1) | SI1809328T1 (zh) |
UA (1) | UA92898C2 (zh) |
WO (1) | WO2006036208A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4960591B2 (ja) * | 2004-12-14 | 2012-06-27 | 味の素ゼネラルフーヅ株式会社 | マンノオリゴ糖類を含有する抗アレルゲン組成物 |
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JP4651723B2 (ja) * | 2009-04-14 | 2011-03-16 | 宗節 金城 | 炒り玄米飲料並びに粥状製品とその製造方法 |
JP2009275047A (ja) * | 2009-06-30 | 2009-11-26 | Ajinomoto General Foods Inc | 体内脂肪低減作用を有する組成物およびこれを含有する飲食物 |
EP2301595B1 (en) * | 2009-09-23 | 2014-01-22 | Dentsply IH AB | Flushable catheter and method for producing such a catheter |
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US8431551B2 (en) | 2010-01-12 | 2013-04-30 | Albert Duoibes | Nutritional composition made using isolated organic matter |
JP2011140516A (ja) * | 2011-04-07 | 2011-07-21 | Ajinomoto General Foods Inc | 糖尿病または糖尿病性合併症の治療、予防、または改善作用を有する組成物およびこれを含有する飲料 |
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CN112812197B (zh) * | 2021-01-11 | 2022-05-31 | 中国药科大学 | 一种兰州百合多糖及其制备方法和应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3973008A (en) * | 1970-12-30 | 1976-08-03 | Kabushiki Kaisha Shimizu Manzo Shoten | Konjac mannan |
US4469681A (en) * | 1979-07-31 | 1984-09-04 | The Rockefeller University | Method and system for the controlled release of biologically active substances to a body fluid |
US4508745A (en) * | 1982-12-30 | 1985-04-02 | General Foods Corporation | Production of a mannan oligomer hydrolysate |
US4484012A (en) * | 1984-02-29 | 1984-11-20 | General Foods Corporation | Production of mannitol and higher manno-saccharide alcohols |
JPS6196947A (ja) * | 1984-10-19 | 1986-05-15 | ゼネラル・フ−ヅ・コ−ポレ−シヨン | マンナンオリゴマーの製造方法 |
CA1324287C (en) | 1988-09-14 | 1993-11-16 | Howard Dave Stahl | Process for hydrolyzing a partially extracted roasted and ground coffee |
JP3043888B2 (ja) * | 1992-02-20 | 2000-05-22 | 森永乳業株式会社 | グルコマンナン部分加水分解物を有効成分とする大腸ガン予防剤 |
KR100785718B1 (ko) * | 1998-05-19 | 2007-12-18 | 리서치 디벨럽먼트 파운데이션 | 트리테르펜 조성물 |
JP2000217546A (ja) * | 1999-01-29 | 2000-08-08 | Showa Sangyo Co Ltd | マンノース含有ヘテロオリゴ糖からなる甘味剤、病原菌感染抑制剤、整腸剤又は澱粉の老化抑制剤及び該剤からなる飲食品、医薬品又は飼料。 |
DE19961182B4 (de) * | 1999-12-18 | 2006-01-12 | Südzucker AG Mannheim/Ochsenfurt | Galactomannan-Oligosaccharide und Verfahren zu deren Herstellung sowie deren Verwendung |
AU2001278161A1 (en) * | 2000-08-08 | 2002-02-18 | Advanced Functional Foods International, Inc. | Nutritional supplement for the management of weight |
JP4684440B2 (ja) * | 2001-03-13 | 2011-05-18 | 味の素ゼネラルフーヅ株式会社 | マンノオリゴ糖を含有する過酸化脂質上昇抑制組成物 |
JP2002262827A (ja) * | 2001-03-13 | 2002-09-17 | Ajinomoto General Foods Inc | マンノオリゴ糖を含有する血清脂質改善組成物 |
AU2002324816B2 (en) * | 2001-08-29 | 2009-09-17 | Bio-Tech Pharmacal, Inc. | D-mannose contraceptives |
JP2005539069A (ja) * | 2002-09-16 | 2005-12-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 組織または生物体の代謝適応能を測定するための生化学的方法 |
JP2005145905A (ja) * | 2003-11-18 | 2005-06-09 | National Institute Of Advanced Industrial & Technology | 血圧降下剤及びその製造方法 |
WO2007086100A1 (ja) * | 2006-01-24 | 2007-08-02 | Ajinomoto General Foods, Inc. | 血圧の降下作用及び/または上昇抑制作用を有する組成物およびこれを含有する飲食物 |
JP4771882B2 (ja) * | 2006-07-21 | 2011-09-14 | 味の素ゼネラルフーヅ株式会社 | 糖尿病または糖尿病性合併症の治療、予防、または改善作用を有する組成物およびこれを含有する飲料 |
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2004
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2005
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- 2005-04-14 BR BRPI0515411-1A patent/BRPI0515411A/pt not_active Application Discontinuation
- 2005-04-14 PT PT5734832T patent/PT1809328E/pt unknown
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- 2005-04-14 US US11/575,362 patent/US20080213425A1/en not_active Abandoned
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102448468A (zh) * | 2009-03-26 | 2012-05-09 | 味之素通用食品株式会社 | 用于预防或治疗生活习惯病的药物组合物以及有助于预防或治疗生活习惯病的食品 |
CN102448468B (zh) * | 2009-03-26 | 2014-12-03 | 味之素通用食品株式会社 | 用于预防或治疗生活习惯病的药物组合物以及有助于预防或治疗生活习惯病的食品 |
Also Published As
Publication number | Publication date |
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CN101087621B (zh) | 2013-01-02 |
CA2580652A1 (en) | 2006-04-06 |
WO2006036208A1 (en) | 2006-04-06 |
PL1809328T3 (pl) | 2013-08-30 |
KR101203778B1 (ko) | 2012-11-21 |
US20080213425A1 (en) | 2008-09-04 |
ES2404694T3 (es) | 2013-05-28 |
EP1809328B1 (en) | 2013-03-13 |
CA2580652C (en) | 2013-02-12 |
DK1809328T3 (da) | 2013-04-15 |
EP1809328A4 (en) | 2007-11-14 |
SI1809328T1 (sl) | 2013-10-30 |
PT1809328E (pt) | 2013-04-08 |
JP4488852B2 (ja) | 2010-06-23 |
KR20070083684A (ko) | 2007-08-24 |
RU2007114280A (ru) | 2008-10-27 |
BRPI0515411A (pt) | 2008-07-22 |
RU2358741C2 (ru) | 2009-06-20 |
JP2006083127A (ja) | 2006-03-30 |
IL181858A0 (en) | 2007-07-04 |
AU2005290262A1 (en) | 2006-04-06 |
EP1809328A1 (en) | 2007-07-25 |
AU2005290262B2 (en) | 2012-01-12 |
UA92898C2 (ru) | 2010-12-27 |
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