CN100444839C - 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用 - Google Patents

式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用 Download PDF

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CN100444839C
CN100444839C CNB038106183A CN03810618A CN100444839C CN 100444839 C CN100444839 C CN 100444839C CN B038106183 A CNB038106183 A CN B038106183A CN 03810618 A CN03810618 A CN 03810618A CN 100444839 C CN100444839 C CN 100444839C
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compound
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directed
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CN1652779A (zh
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A·G·塔弗拉斯
M·比拉
D·伦戴尔
W·克洛伊特纳
J·杰克威
J·S·范恩
L·A·博贝尔
J·曹
P·比于
Y·于
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Merck Sharp and Dohme LLC
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Schering Corp
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CNB038106183A 2002-03-18 2003-03-17 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用 Expired - Fee Related CN100444839C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36531402P 2002-03-18 2002-03-18
US60/365,314 2002-03-18

Publications (2)

Publication Number Publication Date
CN1652779A CN1652779A (zh) 2005-08-10
CN100444839C true CN100444839C (zh) 2008-12-24

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CNB038106183A Expired - Fee Related CN100444839C (zh) 2002-03-18 2003-03-17 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用

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US (2) US20040053953A1 (cg-RX-API-DMAC7.html)
EP (1) EP1485089B1 (cg-RX-API-DMAC7.html)
JP (1) JP4733350B2 (cg-RX-API-DMAC7.html)
CN (1) CN100444839C (cg-RX-API-DMAC7.html)
AR (1) AR040400A1 (cg-RX-API-DMAC7.html)
AU (1) AU2003220384B2 (cg-RX-API-DMAC7.html)
BR (1) BR0308739A (cg-RX-API-DMAC7.html)
CA (1) CA2479126C (cg-RX-API-DMAC7.html)
MX (1) MXPA04009127A (cg-RX-API-DMAC7.html)
NO (1) NO20044402L (cg-RX-API-DMAC7.html)
NZ (1) NZ535314A (cg-RX-API-DMAC7.html)
TW (2) TW200304811A (cg-RX-API-DMAC7.html)
WO (1) WO2003080053A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200407339B (cg-RX-API-DMAC7.html)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
DK1381590T3 (da) * 2001-04-16 2007-10-22 Schering Corp 3,4-disubstituerede cyclobuten-1,2-dioner som CXC-kemokinreceptorligander
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US6903131B2 (en) 2001-10-12 2005-06-07 Schering Corporation 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
DE60326080D1 (en) 2002-10-09 2009-03-19 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden
BR0316106A (pt) * 2002-11-07 2005-09-27 Abbott Lab Processo para carregar um agente benéfico em próteses por aplicação por jato fluido
US8524148B2 (en) * 2002-11-07 2013-09-03 Abbott Laboratories Method of integrating therapeutic agent into a bioerodible medical device
US8221495B2 (en) * 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
EP2168956B8 (en) 2003-04-18 2013-05-01 Merck Sharp & Dohme Corp. Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide
ATE406356T1 (de) 2003-12-19 2008-09-15 Schering Corp Thiadiazole als cxc- und cc- chemokinrezeptorliganden
TW200530231A (en) 2003-12-22 2005-09-16 Schering Corp Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
PE20051093A1 (es) * 2004-01-30 2006-01-16 Schering Corp Polimorfos cristalinos de un ligando receptor de cxc quimiocina
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
CN1997893A (zh) * 2004-04-16 2007-07-11 健泰科生物技术公司 抗体测定法
US7326729B2 (en) * 2004-05-12 2008-02-05 Schering Corporation CXCR1 and CXCR2 chemokine antagonists
AR049384A1 (es) * 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
CA2613607A1 (en) 2005-06-29 2007-01-04 Schering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
ES2353401T3 (es) * 2005-06-29 2011-03-01 Schering Corporation Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos del receptor de cxc-quimiocina.
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
NZ573566A (en) * 2006-06-12 2012-01-12 Schering Corp Pharmaceutical formulations and compositions of a selective antagonist of either cxcr2 or both cxcr1 and cxcr2 and methods of using the same for treating inflammatory disorders
WO2008005570A1 (en) * 2006-07-07 2008-01-10 Schering Corporation 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
ES2386489T3 (es) 2007-06-06 2012-08-21 Novartis Ag Compuestos ciclobutanediona sustituidos anti-inflamatorios
US8519168B2 (en) * 2007-07-03 2013-08-27 Merck Sharp & Dohme Corp. Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
WO2010131147A1 (en) * 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives
FR2961695B1 (fr) * 2010-06-29 2012-07-06 Galderma Res & Dev Utilisation de composes dans le traitement ou la prevention de troubles cutanes
WO2012125413A2 (en) * 2011-03-12 2012-09-20 Vicus Therapeutics, Llc Compositions for ameliorating systemic inflammation and methods for making and using them
PL2760821T3 (pl) 2011-09-02 2018-04-30 Novartis Ag Sól cholinowa przeciwzapalnego związku podstawionego cyklobutenodionem
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
KR101306199B1 (ko) * 2012-01-31 2013-09-09 부산대학교 산학협력단 포스포리파아제 ｄ 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
JP2020530848A (ja) * 2017-08-14 2020-10-29 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ３，４−二置換３−シクロブテン−１，２−ジオンおよびその使用
CA3075892C (en) * 2017-09-14 2024-01-23 Daiichi Sankyo Company, Limited Heterocyclic compounds for the treatment and/or prevention of inflammatory diseases
EP3737366A4 (en) 2018-01-08 2022-07-27 ChemoCentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2
BR112021003956A2 (pt) 2018-09-21 2021-05-25 Pfizer Inc. dioxociclobutenilamino-3-hidróxi-picolinamidas n-substituídas úteis como inibidores de ccr6
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物
EP3868368A1 (en) * 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof
WO2025092968A1 (zh) * 2023-11-03 2025-05-08 武汉朗来科技发展有限公司 作为ccr6拮抗剂的化合物、其药物组合物和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064208A1 (en) * 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2001092202A1 (en) * 2000-05-30 2001-12-06 Smithkline Beecham Corporation Il-8 receptor antagonists
CN1516687A (zh) * 2001-04-16 2004-07-28 ���鹫˾ 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1531943A (fr) 1966-07-28 1968-07-05 Huels Chemische Werke Ag Procédé pour stabiliser des poly-acétals macromoléculaires
DE1669798A1 (de) 1966-07-28 1971-08-26 Huels Chemische Werke Ag Verfahren zum Stabilisieren markomolekularer Polyacetale
CS214745B2 (en) * 1976-08-28 1982-05-28 Huels Chemische Werke Ag Shaped and non-shaped products from plastic materials
DE2638855C3 (de) 1976-08-28 1980-04-24 Chemische Werke Huels Ag, 4370 Marl Verwendung von Quadratsäureamiden als Stabilisierungsmittel für geformte oder nicht geformte Kunststoffe
DE3309655A1 (de) 1983-03-17 1984-09-20 Bayer Ag, 5090 Leverkusen 1,2,5-thiadiazol-1-oxide und 1,1-dioxide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
US4978665A (en) 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
JPH02256668A (ja) 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
GB9312210D0 (en) 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds
US5354763A (en) * 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5506252A (en) * 1993-11-17 1996-04-09 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5466712A (en) 1994-11-04 1995-11-14 American Home Products Corporation Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
JPH10509145A (ja) 1994-11-16 1998-09-08 アメリカン・ホーム・プロダクツ・コーポレイション ジアミノシクロブテン−３，４−ジオン
IL131004A0 (en) * 1997-01-23 2001-01-28 Smithkline Beecham Corp Il-8 receptor antagonists
AU6250298A (en) 1997-01-30 1998-08-25 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
US5840764A (en) * 1997-01-30 1998-11-24 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
AR015425A1 (es) * 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
EP1117633B1 (en) 1998-10-02 2002-09-18 Neurosearch A/S Diaminocyclobutene-3,4-dione derivatives, their preparation and use
ATE284387T1 (de) 1998-10-08 2004-12-15 Smithkline Beecham Plc 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3)
US6376555B1 (en) * 1998-12-04 2002-04-23 American Home Products Corporation 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
WO2000035855A1 (en) 1998-12-14 2000-06-22 American Home Products Corporation 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4
NZ512339A (en) 1998-12-16 2003-03-28 Bayer Ag New biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en) * 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6586446B1 (en) 1999-10-15 2003-07-01 Bristol-Myers Squibb Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
AU2001243351A1 (en) 2000-03-01 2001-09-12 Smith Kline Beecham Corporation Il-8 receptor antagonists
AU2001245724A1 (en) 2000-03-14 2001-09-24 Smith Kline Beecham Corporation Il-8 receptor antagonists
AR035642A1 (es) * 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
ATE346043T1 (de) * 2001-01-16 2006-12-15 Smithkline Beecham Corp Il-8-rezeptorantagonisten
ATE419845T1 (de) * 2001-01-16 2009-01-15 Smithkline Beecham Corp Il-8-rezeptor-antagonisten
CA2436351A1 (en) * 2001-02-02 2002-10-03 Schering Corporation 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20030204085A1 (en) * 2001-02-02 2003-10-30 Taveras Arthur G. 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US6903131B2 (en) * 2001-10-12 2005-06-07 Schering Corporation 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists
US6878709B2 (en) * 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
JP4836388B2 (ja) 2002-03-22 2011-12-14 第一三共株式会社 ｅＮＯＳ発現に起因する疾患の予防または治療薬
DE60326080D1 (en) * 2002-10-09 2009-03-19 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064208A1 (en) * 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2001092202A1 (en) * 2000-05-30 2001-12-06 Smithkline Beecham Corporation Il-8 receptor antagonists
CN1516687A (zh) * 2001-04-16 2004-07-28 ���鹫˾ 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮

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