CL2014002240A1 - Modulador del ligando de tipo delta 3 (dll3), particularmente un anticuerpo; ácido nucleico que lo codifica; célula huésped; conjugado de anticuerpo-fármaco antiproliferativo; uso para el tratamiento del cáncer; medicamento que lo comprende. - Google Patents
Modulador del ligando de tipo delta 3 (dll3), particularmente un anticuerpo; ácido nucleico que lo codifica; célula huésped; conjugado de anticuerpo-fármaco antiproliferativo; uso para el tratamiento del cáncer; medicamento que lo comprende.Info
- Publication number
- CL2014002240A1 CL2014002240A1 CL2014002240A CL2014002240A CL2014002240A1 CL 2014002240 A1 CL2014002240 A1 CL 2014002240A1 CL 2014002240 A CL2014002240 A CL 2014002240A CL 2014002240 A CL2014002240 A CL 2014002240A CL 2014002240 A1 CL2014002240 A1 CL 2014002240A1
- Authority
- CL
- Chile
- Prior art keywords
- antibody
- dll3
- understands
- delta
- medicine
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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