CL2014001339A1 - Procedimiento de preparacion de un compuesto intermediario derivado de 5-fluoro-1h-pirazolopiridina; compuestos intermediarios que participan del mismo y formas cristalinas del compuesto final obtenido, el cual es util en el tratamiento de trastornos cardiocirculatorios. - Google Patents

Procedimiento de preparacion de un compuesto intermediario derivado de 5-fluoro-1h-pirazolopiridina; compuestos intermediarios que participan del mismo y formas cristalinas del compuesto final obtenido, el cual es util en el tratamiento de trastornos cardiocirculatorios.

Info

Publication number
CL2014001339A1
CL2014001339A1 CL2014001339A CL2014001339A CL2014001339A1 CL 2014001339 A1 CL2014001339 A1 CL 2014001339A1 CL 2014001339 A CL2014001339 A CL 2014001339A CL 2014001339 A CL2014001339 A CL 2014001339A CL 2014001339 A1 CL2014001339 A1 CL 2014001339A1
Authority
CL
Chile
Prior art keywords
cardiocirculatory
pyrazolopyridine
participate
fluoro
disorders
Prior art date
Application number
CL2014001339A
Other languages
English (en)
Inventor
Peter Fey
Original Assignee
Bayer Pharma AG
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Ip Gmbh filed Critical Bayer Pharma AG
Publication of CL2014001339A1 publication Critical patent/CL2014001339A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/04—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/037—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CL2014001339A 2011-11-25 2014-05-22 Procedimiento de preparacion de un compuesto intermediario derivado de 5-fluoro-1h-pirazolopiridina; compuestos intermediarios que participan del mismo y formas cristalinas del compuesto final obtenido, el cual es util en el tratamiento de trastornos cardiocirculatorios. CL2014001339A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11190789 2011-11-25
EP11192301 2011-12-07

Publications (1)

Publication Number Publication Date
CL2014001339A1 true CL2014001339A1 (es) 2014-10-17

Family

ID=47222101

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2014001339A CL2014001339A1 (es) 2011-11-25 2014-05-22 Procedimiento de preparacion de un compuesto intermediario derivado de 5-fluoro-1h-pirazolopiridina; compuestos intermediarios que participan del mismo y formas cristalinas del compuesto final obtenido, el cual es util en el tratamiento de trastornos cardiocirculatorios.
CL2016000344A CL2016000344A1 (es) 2011-11-25 2016-02-12 Procedimiento de preparación de 5-fluoro-1h-pirazolopiridinas sustituidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2016000344A CL2016000344A1 (es) 2011-11-25 2016-02-12 Procedimiento de preparación de 5-fluoro-1h-pirazolopiridinas sustituidas

Country Status (42)

Country Link
US (7) US8802847B2 (es)
EP (3) EP3421470B8 (es)
JP (4) JP6189315B2 (es)
KR (3) KR102026059B1 (es)
CN (3) CN106905314A (es)
AP (2) AP3898A (es)
AR (1) AR088983A1 (es)
AU (3) AU2012342547C1 (es)
BR (2) BR112014012414B1 (es)
CA (2) CA2856706C (es)
CL (2) CL2014001339A1 (es)
CO (1) CO6960555A2 (es)
CR (3) CR20210072A (es)
CU (3) CU24354B1 (es)
CY (1) CY1124000T1 (es)
DK (3) DK2782914T3 (es)
DO (3) DOP2014000112A (es)
EA (4) EA201892050A1 (es)
EC (1) ECSP14001627A (es)
ES (3) ES2864009T3 (es)
GT (1) GT201400101A (es)
HK (2) HK1203951A1 (es)
HR (3) HRP20161501T1 (es)
HU (3) HUE041592T2 (es)
IL (3) IL232585A0 (es)
JO (3) JOP20120351B1 (es)
LT (3) LT2782914T (es)
MX (1) MX357481B (es)
MY (3) MY198086A (es)
PE (3) PE20190181A1 (es)
PH (2) PH12014501160A1 (es)
PL (3) PL2896617T3 (es)
PT (3) PT3421470T (es)
RS (3) RS55387B1 (es)
SG (3) SG10201604196VA (es)
SI (3) SI3421470T1 (es)
TR (1) TR201816203T4 (es)
TW (5) TWI597280B (es)
UA (3) UA116623C2 (es)
UY (2) UY34467A (es)
WO (1) WO2013076168A1 (es)
ZA (2) ZA201403613B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
RS55387B1 (sr) 2011-11-25 2017-03-31 Adverio Pharma Gmbh Postupak za dobijanje supstituisanih (z)-alfa-fluoro-beta-amino-akrilaldehida
MX2015010725A (es) 2013-02-21 2016-05-31 Adverio Pharma Gmbh Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato.
TWI639607B (zh) 2013-06-18 2018-11-01 美國禮來大藥廠 Ｂａｃｅ抑制劑
EA201891416A1 (ru) 2015-12-14 2018-12-28 Айронвуд Фармасьютикалз, Инк. ПРИМЕНЕНИЕ СТИМУЛЯТОРОВ sGC ДЛЯ ЛЕЧЕНИЯ ДИСФУНКЦИИ ЖЕЛУДОЧНО-КИШЕЧНОГО СФИНКТЕРА
EP3554488A2 (en) 2016-12-13 2019-10-23 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
CN108727340B (zh) 2017-04-11 2020-12-29 广东东阳光药业有限公司 氟取代的吲唑类化合物及其用途
KR20210031931A (ko) 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
TWI830835B (zh) * 2018-12-17 2024-02-01 德商亞德維瑞醫藥有限公司 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物
KR20210119398A (ko) * 2019-01-22 2021-10-05 아드베리오 파마 게엠베하 4-(2,2,3,3-테트라플루오로프로필)모르폴린을 제조하는 방법
CN115175666B (zh) * 2020-02-03 2024-04-26 阿德弗里奥药品有限责任公司 {4,6-二氨基-2-[5-氟-1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}氨基甲酸甲酯的纳米制剂
EP3925953A1 (en) 2020-06-16 2021-12-22 Adverio Pharma GmbH Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
EP4396185A1 (en) 2021-08-31 2024-07-10 Teva Pharmaceuticals International GmbH Solid state forms of vericiguat and process for preparation thereof
ES2956054B2 (es) * 2022-05-03 2024-07-01 Moehs Iberica Sl 2-(5-FLUORO-1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL)-5-NITROSOPIRIMIDIN-4,6-DIAMINA O UNA SAL DE LA MISMA, PROCEDIMIENTO PARA SU PREPARACION Y SU USO EN LA SINTESIS DE VERICIGUAT
CN115043835B (zh) * 2022-06-17 2023-05-09 常州制药厂有限公司 一种维立西呱的精制纯化方法
WO2024038398A1 (en) * 2022-08-18 2024-02-22 Torrent Pharmaceuticals Limited Novel salt of substituted 5-fluoro-1h-pyrazolopyridines and its uses
CN117924280B (zh) * 2024-03-20 2024-07-12 中国人民解放军军事科学院军事医学研究院 取代噻吩基-5-氟-1h-吡唑并吡啶类化合物及其用途

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606936D0 (en) * 1986-03-20 1986-04-23 Ici Plc Organic compounds
GB9013750D0 (en) 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
BR9712523A (pt) 1996-10-14 2000-05-09 Bayer Ag Novos derivados de pirazol heterociclilmetil-substituìdos
DE19642255A1 (de) 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
US6451805B1 (en) 1997-11-14 2002-09-17 Bayer Aktiengesellschaft Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834045A1 (de) 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19846514A1 (de) 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
HUP0105063A2 (hu) * 1998-11-16 2002-04-29 Basf Ag 3-[Benz(ox/ti)azol-7-il]-1H-pirimidin-2,4-dionok
DE19920352A1 (de) 1999-05-04 2000-11-09 Bayer Ag Substituiertes Pyrazolderivat
WO2002042299A1 (de) 2000-11-22 2002-05-30 Bayer Aktiengesellschaft Neue lactam-substituierte pyrazolopyridinderivate
DE10131987A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Pyridin-substituierte Pyrazolopyridinderivate
AR031176A1 (es) * 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10057754A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Sulfonamid-substituierte Pyrazolopyridinderivate
DE10057751A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Carbamat-substituierte Pyrazolopyridinderivate
DE10122894A1 (de) 2001-05-11 2002-11-14 Bayer Ag Neue Sulfonat-substituierte Pyrazolopyridinderivate
PL208137B1 (pl) 2001-06-22 2011-03-31 Boehringer Ingelheim Pharma Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium
DE10132416A1 (de) 2001-07-04 2003-01-16 Bayer Ag Neue Morpholin-überbrückte Pyrazolopyridinderivate
DE10153737A1 (de) 2001-10-31 2003-05-28 Boehringer Ingelheim Pharma Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
DE10222550A1 (de) 2002-05-17 2003-11-27 Bayer Ag Substituierte Benzyl-pyrazolopyridine
DE10232572A1 (de) 2002-07-18 2004-02-05 Bayer Ag Neue 2,5-disubstituierte Pyrimidinderivate
DE10232571A1 (de) 2002-07-18 2004-02-05 Bayer Ag 4-Aminosubstituierte Pyrimidinderivate
DE10351903A1 (de) 2003-11-06 2005-06-09 Bayer Healthcare Ag Neue Kombination
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung
DE102006031175A1 (de) 2006-07-06 2008-01-10 Bayer Healthcare Ag Wässrige Arzneimittelformulierung von 4-[((4-Carboxybutyl)-(2[(4-phenethyl-benzyl)oxy]-phenethyl)amino)methyl]benzoesäur
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
EP2170884A2 (en) 2007-06-25 2010-04-07 Boehringer Ingelheim International GmbH Chemical compounds
WO2009018415A1 (en) * 2007-07-31 2009-02-05 Vertex Pharmaceuticals Incorporated Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
EP2262498A2 (en) 2008-03-10 2010-12-22 Vertex Pharmceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
KR100979460B1 (ko) * 2008-05-13 2010-09-02 한국과학기술연구원 함불소알킬그룹이 치환된 이온성 액체의 직접 제조방법
DE102009004245A1 (de) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung
PT2504334E (pt) 2009-11-27 2014-12-03 Bayer Ip Gmbh Processo para a purificação de metil-{4,6-diamino-2-[1-(2- fluorobenzil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5- il}metilcarbamato
UY33040A (es) * 2009-11-27 2011-06-30 Bayer Schering Pahrma Akitengesellschaft Nuevas formas polimorfas de {4,6diamino-2-[1-(2-fluorobencil-1h-pirazol[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo
UY33041A (es) 2009-11-27 2011-06-30 Bayer Schering Pharma Aktienegesellschaft Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
DE102010021637A1 (de) * 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
CN103097387B (zh) 2010-07-09 2016-11-02 拜耳知识产权有限责任公司 环稠合的嘧啶和三嗪以及其用于治疗和/或预防心血管疾病的用途
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010040234A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 5-Flour-1H-pyrazolo[3,4-b]pyridin-3-carbonitril
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
CA2847075A1 (en) 2011-09-02 2013-03-07 Bayer Intellectual Property Gmbh Substituted annellated pyrimidine and the use thereof
RS55387B1 (sr) * 2011-11-25 2017-03-31 Adverio Pharma Gmbh Postupak za dobijanje supstituisanih (z)-alfa-fluoro-beta-amino-akrilaldehida

Also Published As

Publication number Publication date
PE20142359A1 (es) 2015-01-09
JOP20210064A1 (ar) 2023-01-30
CU24354B1 (es) 2018-08-06
CU20140055A7 (es) 2014-10-02
KR101993022B1 (ko) 2019-06-25
AU2019202123A1 (en) 2019-04-18
SI2896617T1 (sl) 2016-12-30
EA201491028A1 (ru) 2014-12-30
ES2603028T3 (es) 2017-02-23
US20130143900A1 (en) 2013-06-06
PL3421470T3 (pl) 2021-08-02
DK2896617T3 (en) 2016-12-12
TW201708219A (zh) 2017-03-01
CA2856706C (en) 2020-06-16
UA120278C2 (uk) 2019-11-11
AU2017254916B2 (en) 2019-02-28
CN105503867A (zh) 2016-04-20
PH12015501494A1 (en) 2015-09-07
PH12014501160B1 (en) 2014-10-20
PH12014501160A1 (en) 2014-10-20
KR20140105483A (ko) 2014-09-01
NZ624593A (en) 2016-10-28
EA201892050A1 (ru) 2019-02-28
GT201400101A (es) 2014-11-13
US9150573B2 (en) 2015-10-06
US20140315926A1 (en) 2014-10-23
JP6189315B2 (ja) 2017-08-30
PE20190180A1 (es) 2019-02-01
AU2012342547C1 (en) 2019-02-21
EP2896617A1 (de) 2015-07-22
CR20210072A (es) 2021-03-22
HUE041592T2 (hu) 2019-05-28
US20190177287A1 (en) 2019-06-13
EA033455B1 (ru) 2019-10-31
HK1223613A1 (zh) 2017-08-04
US10633356B2 (en) 2020-04-28
ZA201505970B (en) 2017-08-30
WO2013076168A1 (de) 2013-05-30
CA2856706A1 (en) 2013-05-30
US9845300B2 (en) 2017-12-19
JP6392436B2 (ja) 2018-09-19
US20180065942A1 (en) 2018-03-08
AU2012342547A1 (en) 2014-06-05
UY39646A (es) 2022-04-29
IL232585A0 (en) 2014-06-30
SI3421470T1 (sl) 2021-07-30
UA119269C2 (uk) 2019-05-27
MY197904A (en) 2023-07-24
RS57945B1 (sr) 2019-01-31
AU2012342547B2 (en) 2017-08-17
PT3421470T (pt) 2021-03-31
RS61609B1 (sr) 2021-04-29
KR20190018021A (ko) 2019-02-20
JOP20210065A1 (ar) 2023-01-30
IL246265B (en) 2018-12-31
AU2019202123B2 (en) 2020-09-24
US9604948B2 (en) 2017-03-28
BR112014012414B1 (pt) 2022-01-11
AP2015008243A0 (en) 2015-01-31
CA3040720C (en) 2021-06-15
BR112014012414A2 (pt) 2017-06-06
SG10201604196VA (en) 2016-07-28
US10633357B2 (en) 2020-04-28
US10364229B2 (en) 2019-07-30
AP3898A (en) 2016-11-16
NZ724215A (en) 2018-03-23
EP3421470A1 (de) 2019-01-02
CU20150123A7 (es) 2016-03-31
MX357481B (es) 2018-07-11
DOP2017000013A (es) 2017-02-15
AP2014007705A0 (en) 2014-06-30
US20160009671A1 (en) 2016-01-14
SG10201604192XA (en) 2016-07-28
US8802847B2 (en) 2014-08-12
DK2782914T3 (en) 2018-11-26
EA201491028A8 (ru) 2016-01-29
UA116623C2 (uk) 2018-04-25
TWI659016B (zh) 2019-05-11
NZ721592A (en) 2018-02-23
PT2782914T (pt) 2018-11-16
DOP2021000179A (es) 2021-09-30
MX2014006018A (es) 2014-06-04
CN104159898B (zh) 2017-01-18
SI2782914T1 (sl) 2018-12-31
JOP20120351B1 (ar) 2021-08-17
IL246265A0 (en) 2016-07-31
CY1124000T1 (el) 2022-05-27
CN106905314A (zh) 2017-06-30
CU24257B1 (es) 2017-05-10
MY168412A (en) 2018-11-09
PH12015501494B1 (en) 2015-09-07
TW201831447A (zh) 2018-09-01
BR122020001312B1 (pt) 2022-02-15
JP6340391B2 (ja) 2018-06-06
EP2782914A1 (de) 2014-10-01
TWI597280B (zh) 2017-09-01
JP2015502932A (ja) 2015-01-29
UY34467A (es) 2013-06-28
PE20190181A1 (es) 2019-02-01
PT2896617T (pt) 2016-11-18
CU20150124A7 (es) 2016-03-31
ES2603028T8 (es) 2021-12-29
KR20170130612A (ko) 2017-11-28
TW201932465A (zh) 2019-08-16
HUE031029T2 (en) 2017-06-28
DK3421470T3 (da) 2021-04-06
CN105503867B (zh) 2019-01-11
RS55387B1 (sr) 2017-03-31
PL2896617T3 (pl) 2017-07-31
LT2782914T (lt) 2018-10-10
BR112014012414A8 (pt) 2018-01-23
US20170158652A1 (en) 2017-06-08
JP2017031180A (ja) 2017-02-09
LT2896617T (lt) 2016-12-12
HRP20181818T1 (hr) 2019-01-11
IL263389A (en) 2018-12-31
ZA201403613B (en) 2016-02-24
TW201329076A (zh) 2013-07-16
JP2018199698A (ja) 2018-12-20
SG11201402111QA (en) 2014-08-28
AR088983A1 (es) 2014-07-23
MY198086A (en) 2023-07-31
IL263389B (en) 2022-03-01
EA201690520A1 (ru) 2016-07-29
ES2864009T3 (es) 2021-10-13
TWI631123B (zh) 2018-08-01
AU2017254916A1 (en) 2017-11-23
HRP20161501T1 (hr) 2016-12-16
CO6960555A2 (es) 2014-05-30
DOP2014000112A (es) 2014-07-15
HUE053745T2 (hu) 2021-07-28
CR20140237A (es) 2014-06-19
KR102026059B1 (ko) 2019-09-26
US20190177288A1 (en) 2019-06-13
EA201690521A1 (ru) 2016-06-30
EP3421470B8 (de) 2021-08-11
PL2782914T3 (pl) 2019-01-31
EP3421470B1 (de) 2021-01-20
TW201838993A (zh) 2018-11-01
CL2016000344A1 (es) 2017-02-10
HK1203951A1 (en) 2015-11-06
EP2896617B1 (de) 2016-10-05
ECSP14001627A (es) 2015-11-30
CN104159898A (zh) 2014-11-19
EA030018B1 (ru) 2018-06-29
EA031602B1 (ru) 2019-01-31
EP2782914B1 (de) 2018-08-01
JP2018058860A (ja) 2018-04-12
TWI665198B (zh) 2019-07-11
ES2694158T3 (es) 2018-12-18
LT3421470T (lt) 2021-04-26
CR20190057A (es) 2019-04-23
CA3040720A1 (en) 2013-05-30
HRP20210507T1 (hr) 2021-05-28
TR201816203T4 (tr) 2018-11-21
KR101943788B1 (ko) 2019-01-29

Similar Documents

Publication Publication Date Title
CL2014001339A1 (es) Procedimiento de preparacion de un compuesto intermediario derivado de 5-fluoro-1h-pirazolopiridina; compuestos intermediarios que participan del mismo y formas cristalinas del compuesto final obtenido, el cual es util en el tratamiento de trastornos cardiocirculatorios.
LTC2785706I2 (lt) Pakeistieji 4-fenil-piridinai, skirti su nk-receptoriumi susijusių ligų gydymui
CO2017001884A2 (es) Polimorfos de selinexor
CL2015001442A1 (es) Metodo para tratar enfermedades pulmonares que comprende el uso de compuestos derivados del acido obeticolico.
CL2015000873A1 (es) Métodos para el tratamiento del síndrome de alport.
DK3305317T3 (da) Forbindelser til behandling af neuropsykiatriske forstyrrelser
EP2709970A4 (en) INTEGRATED PROCESS FOR THE PREPARATION OF 1-CHLORO-3,3,3-TRIFLUORPROPENES
CO6791613A2 (es) Tratamiento de transtornos del espectro autista que utiliza ácido glicil-l-2-metilprolil-l-glutámico
BR112013019520A2 (pt) método para produção de 2,3-butanodiol por fermentação
EA201600429A1 (ru) Способ очистки 2,5-дихлорфенола
ZA201506551B (en) An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine
MX370253B (es) Composiciones de compuestos de jasmonato y métodos de uso de las mismas.
HRP20181481T1 (hr) D-metadon za liječenje psihijatrijskih simptoma
EA201690557A1 (ru) Способы лечения синдрома ломкой х-хромосомы и связанных расстройств
DK2807170T3 (da) Phragmalin-limonoider til behandlingen af seksuel dysfunktion
EP2941255A4 (en) METHOD FOR TREATING OR RELIEVING A DISEASE CAUSED OR AGGRAVATED BY MICROORGANISMS
GB2554624B (en) Process for the Treatment of Ashes and Digestates, Treated Ashes and Digestates thus obtained and uses thereof.
EP3013372A4 (en) METHOD FOR THE TREATMENT OF URBAN CYCLES DISORDERS FOR PREVENTING HYPERAMOMAEMIC CRISES BY REGULATING THE AMMONIA MIRROR IN THE BLOOD
CL2017002304A1 (es) Métodos para tratar enfermedades
WO2012138653A3 (en) Treatment regimens
CO7141428A2 (es) Proceso para la elaboración de undecapéptidos cíclicos
ES2539624B2 (es) Procedimiento para la síntesis de titanias funcionalizadas in situ y el uso de las mismas
CL2016000498A1 (es) Proceso para la producción de lactato.
CL2014003510A1 (es) Composición con factores de crecimiento obtenidos a partir del plasma sanguíneo destinada al tratamiento de enfermedades neurodegenerativas.
IN2013MU04030A (es)