CO6791613A2 - Tratamiento de transtornos del espectro autista que utiliza ácido glicil-l-2-metilprolil-l-glutámico - Google Patents
Tratamiento de transtornos del espectro autista que utiliza ácido glicil-l-2-metilprolil-l-glutámicoInfo
- Publication number
- CO6791613A2 CO6791613A2 CO13200227A CO13200227A CO6791613A2 CO 6791613 A2 CO6791613 A2 CO 6791613A2 CO 13200227 A CO13200227 A CO 13200227A CO 13200227 A CO13200227 A CO 13200227A CO 6791613 A2 CO6791613 A2 CO 6791613A2
- Authority
- CO
- Colombia
- Prior art keywords
- methylprolyl
- glycyl
- treatment
- glutamic acid
- autism spectrum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161462141P | 2011-01-27 | 2011-01-27 | |
US201161492248P | 2011-06-01 | 2011-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6791613A2 true CO6791613A2 (es) | 2013-11-14 |
Family
ID=46581110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13200227A CO6791613A2 (es) | 2011-01-27 | 2013-08-23 | Tratamiento de transtornos del espectro autista que utiliza ácido glicil-l-2-metilprolil-l-glutámico |
Country Status (19)
Country | Link |
---|---|
US (2) | US9708366B2 (es) |
EP (1) | EP2667715B1 (es) |
JP (3) | JP6348283B2 (es) |
AU (1) | AU2012209466C1 (es) |
BR (1) | BR112013018898B1 (es) |
CA (1) | CA2823218C (es) |
CO (1) | CO6791613A2 (es) |
CY (1) | CY1119455T1 (es) |
DK (1) | DK2667715T3 (es) |
ES (1) | ES2641880T3 (es) |
HR (1) | HRP20171478T1 (es) |
HU (1) | HUE036637T2 (es) |
IL (1) | IL227669B (es) |
LT (1) | LT2667715T (es) |
PL (1) | PL2667715T3 (es) |
PT (1) | PT2667715T (es) |
RS (1) | RS56461B1 (es) |
SI (1) | SI2667715T1 (es) |
WO (1) | WO2012102832A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9708366B2 (en) * | 2011-01-27 | 2017-07-18 | Neuren Pharmaceuticals Ltd. | Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate |
US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
BR112015012506A2 (pt) * | 2012-11-28 | 2017-07-11 | Neuren Pharmaceuticals Ltd | tratamento de transtornos do espectro do autismo usando ácido glicil-l-2-metilprolil-l-glutâmico |
SI3024463T1 (sl) * | 2013-07-25 | 2020-08-31 | Neuren Pharmaceuticals Limited | Nevroprotektivne biciklične spojine in postopki za njihovo uporabo pri zdravljenju motenj avtističnega spektra in nevrorazvojnih motenj |
MX368628B (es) | 2013-09-23 | 2019-10-08 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Tripeptidos antiinflamatorios. |
BR112016028653A2 (pt) * | 2014-06-06 | 2018-07-10 | Deakin University | métodos de tratamento de doenças e distúrbios neurodesenvolvimentais |
RU2608444C1 (ru) * | 2015-10-02 | 2017-01-18 | Закрытое Акционерное Общество "Алмаз Фарм" | Средство для лечения и профилактики расстройств аутистического спектра |
WO2017064876A1 (ja) | 2015-10-14 | 2017-04-20 | 学校法人 久留米大学 | グレリンを有効成分として含有するレット症候群(rtt)の予防・治療剤 |
US11972336B2 (en) | 2015-12-18 | 2024-04-30 | Cognoa, Inc. | Machine learning platform and system for data analysis |
CN109071559A (zh) * | 2016-05-04 | 2018-12-21 | 亲神经剂生物科学有限公司 | 用于治疗雷特综合征的方法和组合物 |
DK3570940T3 (da) | 2017-01-20 | 2024-02-19 | Prilenia Neurotherapeutics Ltd | Pridopidin til anvendelse i behandling af fragilt x-syndrom |
EP3580700A4 (en) | 2017-02-09 | 2020-11-18 | Cognoa, Inc. | PLATFORM AND SYSTEM FOR DIGITAL PERSONALIZED MEDICINE |
CA3128037A1 (en) * | 2019-02-01 | 2020-08-06 | Revivo Therapeutics | Nomethiazoles as a treatment for rett syndrome |
CA3134521A1 (en) | 2019-03-22 | 2020-10-01 | Cognoa, Inc. | Personalized digital therapy methods and devices |
MX2022001505A (es) | 2019-08-05 | 2022-03-11 | Neuren Pharmaceuticals Ltd | Composiciones de trofinetida. |
EP4051308A4 (en) * | 2019-10-28 | 2023-08-23 | ACADIA Pharmaceuticals Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF RETT SYNDROME |
IT202100004964A1 (it) * | 2021-03-03 | 2022-09-03 | Univ Degli Studi Di Bari Aldo Moro | Agonisti del recettore fpr2 (formyl peptide receptor 2) e loro uso nel trattamento del disturbo dello spettro autistico. |
IL310045A (en) | 2021-07-12 | 2024-03-01 | Acadia Pharm Inc | Crystalline forms of tropintide |
CN114128672B (zh) * | 2021-11-21 | 2023-04-07 | 河南省儿童医院郑州儿童医院 | 一种孤独症大鼠模型的构建方法 |
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0142641B1 (de) | 1983-09-26 | 1991-01-16 | Udo Dr. Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
DK15888D0 (da) | 1988-01-14 | 1988-01-14 | Carlsberg Biotechnology Ltd | Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden |
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JPH09509404A (ja) | 1993-12-23 | 1997-09-22 | オークランド ユニサービシズ リミテッド | 神経アウトカムを改良するための組成物及び方法 |
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US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
US20070004641A1 (en) | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
JP2004536069A (ja) * | 2001-05-24 | 2004-12-02 | ニューロンズ・リミテッド | Gpe類縁体及びペプチドミメティック |
US8637567B2 (en) | 2001-05-24 | 2014-01-28 | Neuren Pharmaceuticals Ltd. | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid |
US7605177B2 (en) * | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
US7863304B2 (en) | 2001-05-24 | 2011-01-04 | Neuren Pharmaceuticals Limited | Analogs of glycyl-prolyl-glutamate |
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EP1793671B1 (en) * | 2004-09-20 | 2011-04-27 | Mount Sinai School of Medicine | Use of memantine (namenda) to treat autism, compulsivity, and impulsivity |
EP1888618A4 (en) * | 2005-05-23 | 2009-07-15 | Neuren Pharmaceuticals Ltd | GLYCYL-PROLYL-GLUTAMATE ANALOGS |
ES2487493T3 (es) | 2006-03-14 | 2014-08-21 | Neuren Pharmaceuticals Limited | Formulaciones orales de glicil-2-metilprolil-glutamato |
GB0707127D0 (en) * | 2007-04-13 | 2007-05-23 | Zysis Ltd | Pharmaceutical compositions |
AU2008262387A1 (en) * | 2007-06-08 | 2008-12-18 | Massachusetts Institute Of Technology | IGF for the treatment of Rett Syndrome and synaptic disorders |
TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
CA2749783A1 (en) | 2009-01-16 | 2010-07-22 | Massachusetts Institute Of Technology | Diagnosis and treatment of autism spectrum disorders |
ES2617309T3 (es) | 2010-05-17 | 2017-06-16 | Icahn School Of Medicine At Mount Sinai | Métodos y ensayos de tratamiento de sujetos con eliminación, mutación o expresión reducida de SHANK3 |
US9708366B2 (en) | 2011-01-27 | 2017-07-18 | Neuren Pharmaceuticals Ltd. | Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate |
-
2012
- 2012-01-27 US US13/699,087 patent/US9708366B2/en active Active
- 2012-01-27 RS RS20171001A patent/RS56461B1/sr unknown
- 2012-01-27 AU AU2012209466A patent/AU2012209466C1/en active Active
- 2012-01-27 CA CA2823218A patent/CA2823218C/en active Active
- 2012-01-27 EP EP12739509.3A patent/EP2667715B1/en active Active
- 2012-01-27 JP JP2013551979A patent/JP6348283B2/ja active Active
- 2012-01-27 SI SI201231075T patent/SI2667715T1/sl unknown
- 2012-01-27 BR BR112013018898-7A patent/BR112013018898B1/pt active IP Right Grant
- 2012-01-27 HU HUE12739509A patent/HUE036637T2/hu unknown
- 2012-01-27 LT LTEP12739509.3T patent/LT2667715T/lt unknown
- 2012-01-27 PT PT127395093T patent/PT2667715T/pt unknown
- 2012-01-27 DK DK12739509.3T patent/DK2667715T3/en active
- 2012-01-27 PL PL12739509T patent/PL2667715T3/pl unknown
- 2012-01-27 ES ES12739509.3T patent/ES2641880T3/es active Active
- 2012-01-27 WO PCT/US2012/000047 patent/WO2012102832A1/en active Application Filing
-
2013
- 2013-07-25 IL IL227669A patent/IL227669B/en active IP Right Grant
- 2013-08-23 CO CO13200227A patent/CO6791613A2/es not_active Application Discontinuation
-
2015
- 2015-01-26 US US14/605,420 patent/US9212204B2/en active Active
-
2016
- 2016-09-09 JP JP2016176567A patent/JP6342459B2/ja active Active
-
2017
- 2017-10-04 HR HRP20171478TT patent/HRP20171478T1/hr unknown
- 2017-10-12 CY CY20171101074T patent/CY1119455T1/el unknown
-
2018
- 2018-05-16 JP JP2018094320A patent/JP6640275B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
AU2012209466B2 (en) | 2016-02-25 |
CY1119455T1 (el) | 2018-04-04 |
SI2667715T1 (sl) | 2017-11-30 |
PL2667715T3 (pl) | 2018-02-28 |
JP6348283B2 (ja) | 2018-06-27 |
EP2667715B1 (en) | 2017-07-19 |
US20150197543A1 (en) | 2015-07-16 |
PT2667715T (pt) | 2017-10-19 |
US9212204B2 (en) | 2015-12-15 |
BR112013018898B1 (pt) | 2021-10-05 |
CA2823218A1 (en) | 2012-08-02 |
WO2012102832A1 (en) | 2012-08-02 |
JP2014508744A (ja) | 2014-04-10 |
AU2012209466C1 (en) | 2016-06-23 |
BR112013018898A2 (pt) | 2017-04-18 |
ES2641880T3 (es) | 2017-11-14 |
IL227669B (en) | 2020-06-30 |
LT2667715T (lt) | 2017-11-10 |
US20140147491A1 (en) | 2014-05-29 |
US9708366B2 (en) | 2017-07-18 |
HUE036637T2 (hu) | 2018-07-30 |
EP2667715A1 (en) | 2013-12-04 |
DK2667715T3 (en) | 2017-10-23 |
JP6640275B2 (ja) | 2020-02-05 |
AU2012209466A1 (en) | 2013-09-05 |
CA2823218C (en) | 2021-04-20 |
IL227669A0 (en) | 2013-09-30 |
HRP20171478T1 (hr) | 2017-11-17 |
EP2667715A4 (en) | 2014-07-23 |
RS56461B1 (sr) | 2018-01-31 |
JP2016210808A (ja) | 2016-12-15 |
JP6342459B2 (ja) | 2018-06-13 |
JP2018138606A (ja) | 2018-09-06 |
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Legal Events
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FC | Application refused |