HRP20171478T1 - Liječenje poremećaja autističnog spektra pomoću glicil-l-2-metilprolil-l-glutaminske kiseline - Google Patents
Liječenje poremećaja autističnog spektra pomoću glicil-l-2-metilprolil-l-glutaminske kiseline Download PDFInfo
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- HRP20171478T1 HRP20171478T1 HRP20171478TT HRP20171478T HRP20171478T1 HR P20171478 T1 HRP20171478 T1 HR P20171478T1 HR P20171478T T HRP20171478T T HR P20171478TT HR P20171478 T HRP20171478 T HR P20171478T HR P20171478 T1 HRP20171478 T1 HR P20171478T1
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- growth factor
- mepe
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- fgf
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- 208000029560 autism spectrum disease Diseases 0.000 title claims 6
- BUSXWGRAOZQTEY-SDBXPKJASA-N trofinetide Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@]1(C)CCCN1C(=O)CN BUSXWGRAOZQTEY-SDBXPKJASA-N 0.000 title 1
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- QUCFVNGGGFLOES-ACQYNFKHSA-N (4s)-5-[[(2s)-1-[[(2s)-1-[[(2r)-6-amino-1-[[(1s)-1-carboxy-2-phenylethyl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2s)-2-amino-4-methylsulfonylbutanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCS(=O)(=O)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CN=CN1 QUCFVNGGGFLOES-ACQYNFKHSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- Engineering & Computer Science (AREA)
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Claims (7)
1. Glicil-2-metil-L-prolil-L-glutamat (G-2-MePE) za primjenu u liječenju simptoma odabranih iz grupe koja se sastoji od smanjenog socijalnog funkcioniranja i repetitivnog ponašanja poremećaja autističnog spektra (ASD) kod životinje, oralnom primjenom djelotvorne količine G-2-MePE.
2. G-2-MePE za primjenu prema zahtjevu 1, naznačen time, što spomenuto liječenje dovodi do poboljšanja spomenutih simptoma, što se procjenjuje pomoću jednog ili više testova ponašanja odabranih iz grupe koja se sastoji od Rett Syndrome Natural History / Clinical Severity Scale, Aberrant Behavior Checklist Community Edition (ABC), Vinelands, Clinical Global Impression of Severity (CGI-S) i Caregiver Strain Questionnaire (CSQ) ili pomoću jednog ili više psiholoških testova odabranih iz grupe koja se sastoji od frekvencije šiljaka elektroencefalograma (EEG), ukupne snage u frekvencijskim pojasevima EEG-a, pokreta ruku, varijabilnosti srčanog ritma (HRV) i respiratornih iregularnosti u usporedbi s kontrolnim životinjama koje ne pate od spomenutog simptoma.
3. G-2-MePE za primjenu prema zahtjevu 1 ili zahtjevu 2, naznačen time, što je spomenuti poremećaj autističnog spektra odabran iz grupe koja se sastoji od autizma, sindroma fragilnog X kromosoma, Rettovog sindroma (RTT), autističnog poremećaja, Aspergerovog sindroma, dječjeg dezintegrativnog poremećaja i pervazivnog razvojnog poremećaja koji nije drugačije specificiran (PDD-NOS) te patološkog izbjegavanja zahtjeva (PDA).
4. G-2-MePE za primjenu prema bilo kojem zahtjevu od 1 do 3, pri čemu se spomenuta djelotvorna količina G-2-MePE kreće u rasponu od 1 mg/kg do 100 mg/kg.
5. G-2-MePE za primjenu prema bilo kojem zahtjevu od 1 do 4, naznačen time, što drugo terapijsko sredstvo odabrano iz grupe koja se sastoji od sljedećih: faktor rasta sličan inzulinu-I (IGF-I), faktora rast sličan inzulinu-II (IGF-II), glicil-prolil-glutamat (GPE), transformirajući faktora rasta-β1, aktivina, hormon rasta, nervni faktor rasta, neutrofni moždani faktor (BDNF), protein koji veže hormon rasta, proteini koji vezuju IGF (posebno IGFBP-3), bazični faktor rasta fibroblasta, kiselinski faktor rasta fibroblasta, genski produkt hst/Kfgk, FGF-3, FGF-4, FGF-6, faktor rasta keratinocita, androgenom inducirani faktor rasta, int-2, homologni faktor-1 faktora rasta fibroblasta (FHF-1), FHF-2, FHF-3 i FHF-4, faktor rasta keratinocita 2, faktor aktivacije glija, FGF-10 i FGF-16, ciliarni neutrofni faktor, moždani faktor rasta, neurotropin 3, neurotropin 4, koštani morfogenetski protein 2 (BMP-2), neurotropfni faktor dobiven iz stanične linije glija, neurotrofni faktor ovisan o aktivnosti, citokinski faktor koji inhibira leukemiju, onkostatin M, interleukin, α-, β-, γ- ili konsenzusni interferon, TNF-α, klometiazol, kinurenska kiselina, Semax, takrolimus, L-treo-1-fenil-2-dekanoilamono-3-morfolino-1-propanol, analog andrenokortikotropina-(4-9) [ORG 2766] i dizolcipin (MK-801), selegilin, antagonisti glutamata kao što su mematin (Namenda) NPS1506, GV1505260, MK-801, GV150526; antagonisti AMPA kao što su 2,3-dihidroksi-6-nitro-7-sulfamoilbenzo(f)kinoksalin (NBQX), LY303070 i LY300164, protuupalna sredstva usmjerena protiv adresina MAdCAM-1 i/ili njegovih integrinskih α4 receptora (α4β1 i α4β7)m kao što su anti-MAdCAM-imAb MECA-367 (ATCC pristupni br. HB-9478), fenobam, selektivni inhibitor ponovne pohrane serotonina kao što je fluoksetin ili atipični antipsihotici kao što je risperidon se primjenjuje kod životinje.
6. G-2-MePE za primjenu prema bilo kojem zahtjevu od 1 do 5, naznačen time, što doza spomenutog spoja iznosi 10 mg/kg tri puta dnevno ili 20 mg/kg tri puta dnevno.
7. G-2-MePE za primjenu prema bilo kojem zahtjevu od 1 do 6, naznačen time, što je spomenuta životinja čovjek.
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| PCT/US2012/000047 WO2012102832A1 (en) | 2011-01-27 | 2012-01-27 | Treatment of autism spectrum disorderes using glycyl-l-2-methylprolyl-l-glutamic acid |
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| US20140147491A1 (en) | 2014-05-29 |
| DK2667715T3 (en) | 2017-10-23 |
| PL2667715T3 (pl) | 2018-02-28 |
| AU2012209466B2 (en) | 2016-02-25 |
| RS56461B1 (sr) | 2018-01-31 |
| EP2667715A4 (en) | 2014-07-23 |
| JP2014508744A (ja) | 2014-04-10 |
| LT2667715T (lt) | 2017-11-10 |
| JP6342459B2 (ja) | 2018-06-13 |
| AU2012209466A1 (en) | 2013-09-05 |
| JP6348283B2 (ja) | 2018-06-27 |
| HUE036637T2 (hu) | 2018-07-30 |
| SI2667715T1 (sl) | 2017-11-30 |
| PT2667715T (pt) | 2017-10-19 |
| AU2012209466C1 (en) | 2016-06-23 |
| JP6640275B2 (ja) | 2020-02-05 |
| EP2667715A1 (en) | 2013-12-04 |
| JP2016210808A (ja) | 2016-12-15 |
| CA2823218C (en) | 2021-04-20 |
| CO6791613A2 (es) | 2013-11-14 |
| US20150197543A1 (en) | 2015-07-16 |
| ES2641880T3 (es) | 2017-11-14 |
| CY1119455T1 (el) | 2018-04-04 |
| US9212204B2 (en) | 2015-12-15 |
| EP2667715B1 (en) | 2017-07-19 |
| IL227669B (en) | 2020-06-30 |
| WO2012102832A1 (en) | 2012-08-02 |
| CA2823218A1 (en) | 2012-08-02 |
| BR112013018898A2 (pt) | 2017-04-18 |
| BR112013018898B1 (pt) | 2021-10-05 |
| IL227669A0 (en) | 2013-09-30 |
| JP2018138606A (ja) | 2018-09-06 |
| US9708366B2 (en) | 2017-07-18 |
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