PL2667715T3 - Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowego - Google Patents
Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowegoInfo
- Publication number
- PL2667715T3 PL2667715T3 PL12739509T PL12739509T PL2667715T3 PL 2667715 T3 PL2667715 T3 PL 2667715T3 PL 12739509 T PL12739509 T PL 12739509T PL 12739509 T PL12739509 T PL 12739509T PL 2667715 T3 PL2667715 T3 PL 2667715T3
- Authority
- PL
- Poland
- Prior art keywords
- methylprolyl
- glycyl
- treatment
- glutamic acid
- autism spectrum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161462141P | 2011-01-27 | 2011-01-27 | |
| US201161492248P | 2011-06-01 | 2011-06-01 | |
| EP12739509.3A EP2667715B1 (en) | 2011-01-27 | 2012-01-27 | Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid |
| PCT/US2012/000047 WO2012102832A1 (en) | 2011-01-27 | 2012-01-27 | Treatment of autism spectrum disorderes using glycyl-l-2-methylprolyl-l-glutamic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2667715T3 true PL2667715T3 (pl) | 2018-02-28 |
Family
ID=46581110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12739509T PL2667715T3 (pl) | 2011-01-27 | 2012-01-27 | Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowego |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9708366B2 (pl) |
| EP (1) | EP2667715B1 (pl) |
| JP (3) | JP6348283B2 (pl) |
| AU (1) | AU2012209466C1 (pl) |
| BR (1) | BR112013018898B1 (pl) |
| CA (1) | CA2823218C (pl) |
| CO (1) | CO6791613A2 (pl) |
| CY (1) | CY1119455T1 (pl) |
| DK (1) | DK2667715T3 (pl) |
| ES (1) | ES2641880T3 (pl) |
| HR (1) | HRP20171478T1 (pl) |
| HU (1) | HUE036637T2 (pl) |
| IL (1) | IL227669B (pl) |
| LT (1) | LT2667715T (pl) |
| PL (1) | PL2667715T3 (pl) |
| PT (1) | PT2667715T (pl) |
| RS (1) | RS56461B1 (pl) |
| SI (1) | SI2667715T1 (pl) |
| WO (1) | WO2012102832A1 (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2823218C (en) | 2011-01-27 | 2021-04-20 | Neuren Pharmaceuticals Limited | Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid |
| WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| EP2928300A4 (en) * | 2012-11-28 | 2016-07-13 | Neuren Pharmaceuticals Ltd | TREATMENT OF AUTISTIC SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID |
| PL3024463T3 (pl) * | 2013-07-25 | 2020-10-05 | Neuren Pharmaceuticals Limited | Neuroprotekcyjne związki bicykliczne i sposoby ich zastosowania w leczeniu spektrum zaburzeń autystycznych i zaburzeń neurorozwojowych |
| KR20160058841A (ko) | 2013-09-23 | 2016-05-25 | 독토르. 아우구스트 볼프 게엠베하 운트 코. 카게 아르쯔네이미텔 | 항염증성 트리펩티드 |
| NZ727412A (en) * | 2014-06-06 | 2023-07-28 | Wah Chin Boon | Methods of treating neurodevelopmental diseases and disorders |
| RU2608444C1 (ru) * | 2015-10-02 | 2017-01-18 | Закрытое Акционерное Общество "Алмаз Фарм" | Средство для лечения и профилактики расстройств аутистического спектра |
| JP6694216B2 (ja) | 2015-10-14 | 2020-05-13 | 学校法人 久留米大学 | グレリンを有効成分として含有するレット症候群（ｒｔｔ）の予防・治療剤 |
| US11972336B2 (en) | 2015-12-18 | 2024-04-30 | Cognoa, Inc. | Machine learning platform and system for data analysis |
| KR20190005158A (ko) * | 2016-05-04 | 2019-01-15 | 뉴로트롭 바이오싸이언스 인크. | 레트 증후군의 치료를 위한 방법 및 조성물 |
| WO2018136600A1 (en) * | 2017-01-20 | 2018-07-26 | Teva Pharmaceuticals International Gmbh | Use of pridopidine for the treatment of fragile x syndrome |
| WO2018148365A1 (en) | 2017-02-09 | 2018-08-16 | Cognoa, Inc. | Platform and system for digital personalized medicine |
| WO2020160541A1 (en) * | 2019-02-01 | 2020-08-06 | Revivo Therapeutics | Nomethiazoles as a treatment for rett syndrome |
| AU2020248351A1 (en) | 2019-03-22 | 2021-11-11 | Cognoa, Inc. | Personalized digital therapy methods and devices |
| WO2021026066A1 (en) * | 2019-08-05 | 2021-02-11 | Neuren Pharmaceuticals Limited | Compositions of trofinetide |
| IL292617A (en) * | 2019-10-28 | 2022-07-01 | Acadia Pharm Inc | Preparations for the treatment of Rett syndrome |
| IT202100004964A1 (it) * | 2021-03-03 | 2022-09-03 | Univ Degli Studi Di Bari Aldo Moro | Agonisti del recettore fpr2 (formyl peptide receptor 2) e loro uso nel trattamento del disturbo dello spettro autistico. |
| KR20240035406A (ko) * | 2021-07-12 | 2024-03-15 | 아카디아 파마슈티칼스 인코포레이티드 | 트로피네타이드의 결정형 |
| CN114128672B (zh) * | 2021-11-21 | 2023-04-07 | 河南省儿童医院郑州儿童医院 | 一种孤独症大鼠模型的构建方法 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| ATE12348T1 (de) | 1980-11-10 | 1985-04-15 | Gersonde Klaus Prof Dr | Verfahren zur herstellung von lipid-vesikeln durch ultraschallbehandlung, anwendung des verfahrens und vorrichtung zur durchfuehrung des verfahrens. |
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| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
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| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
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| SE8803847A0 (sv) | 1988-10-27 | 1990-04-28 | Kabigen Ab | Neuromodulerande peptid |
| WO1995017204A1 (en) | 1993-12-23 | 1995-06-29 | Auckland Uniservices Limited | Composition and methods to improve neural outcome |
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| JP2001501930A (ja) | 1996-10-04 | 2001-02-13 | オークランド ユニサーヴィスィズ リミテッド | 神経酵素の調節 |
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| EP1351976A2 (en) | 2000-08-24 | 2003-10-15 | Neuronz Limited | Gpe analogs |
| US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
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| US7863304B2 (en) | 2001-05-24 | 2011-01-04 | Neuren Pharmaceuticals Limited | Analogs of glycyl-prolyl-glutamate |
| US20070004641A1 (en) | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
| US8637567B2 (en) | 2001-05-24 | 2014-01-28 | Neuren Pharmaceuticals Ltd. | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid |
| US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
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| DK1793671T3 (da) * | 2004-09-20 | 2011-08-22 | Sinai School Medicine | Anvendelse af memantin (namenda) til behandling af autisme, tvangstilstand og impulsivitet |
| EP1888618A4 (en) * | 2005-05-23 | 2009-07-15 | Neuren Pharmaceuticals Ltd | GLYCYL-PROLYL-GLUTAMATE ANALOGS |
| EP2001400B1 (en) | 2006-03-14 | 2014-05-07 | Neuren Pharmaceuticals Limited | Oral formulations of glycyl-2-methylprolyl-glutamate |
| GB0707127D0 (en) * | 2007-04-13 | 2007-05-23 | Zysis Ltd | Pharmaceutical compositions |
| CN101820896A (zh) | 2007-06-08 | 2010-09-01 | 麻省理工学院 | 用于治疗雷特综合征和突触病症的igf |
| TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
| CA2749783A1 (en) | 2009-01-16 | 2010-07-22 | Massachusetts Institute Of Technology | Diagnosis and treatment of autism spectrum disorders |
| ES2617309T3 (es) | 2010-05-17 | 2017-06-16 | Icahn School Of Medicine At Mount Sinai | Métodos y ensayos de tratamiento de sujetos con eliminación, mutación o expresión reducida de SHANK3 |
| CA2823218C (en) | 2011-01-27 | 2021-04-20 | Neuren Pharmaceuticals Limited | Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid |
-
2012
- 2012-01-27 CA CA2823218A patent/CA2823218C/en active Active
- 2012-01-27 US US13/699,087 patent/US9708366B2/en active Active
- 2012-01-27 SI SI201231075T patent/SI2667715T1/sl unknown
- 2012-01-27 DK DK12739509.3T patent/DK2667715T3/en active
- 2012-01-27 BR BR112013018898-7A patent/BR112013018898B1/pt active IP Right Grant
- 2012-01-27 HU HUE12739509A patent/HUE036637T2/hu unknown
- 2012-01-27 LT LTEP12739509.3T patent/LT2667715T/lt unknown
- 2012-01-27 PL PL12739509T patent/PL2667715T3/pl unknown
- 2012-01-27 JP JP2013551979A patent/JP6348283B2/ja active Active
- 2012-01-27 RS RS20171001A patent/RS56461B1/sr unknown
- 2012-01-27 PT PT127395093T patent/PT2667715T/pt unknown
- 2012-01-27 ES ES12739509.3T patent/ES2641880T3/es active Active
- 2012-01-27 EP EP12739509.3A patent/EP2667715B1/en active Active
- 2012-01-27 AU AU2012209466A patent/AU2012209466C1/en active Active
- 2012-01-27 WO PCT/US2012/000047 patent/WO2012102832A1/en active Application Filing
-
2013
- 2013-07-25 IL IL227669A patent/IL227669B/en active IP Right Grant
- 2013-08-23 CO CO13200227A patent/CO6791613A2/es not_active Application Discontinuation
-
2015
- 2015-01-26 US US14/605,420 patent/US9212204B2/en active Active
-
2016
- 2016-09-09 JP JP2016176567A patent/JP6342459B2/ja active Active
-
2017
- 2017-10-04 HR HRP20171478TT patent/HRP20171478T1/hr unknown
- 2017-10-12 CY CY20171101074T patent/CY1119455T1/el unknown
-
2018
- 2018-05-16 JP JP2018094320A patent/JP6640275B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014508744A (ja) | 2014-04-10 |
| SI2667715T1 (sl) | 2017-11-30 |
| EP2667715A1 (en) | 2013-12-04 |
| US9708366B2 (en) | 2017-07-18 |
| HUE036637T2 (hu) | 2018-07-30 |
| JP2018138606A (ja) | 2018-09-06 |
| US20150197543A1 (en) | 2015-07-16 |
| DK2667715T3 (en) | 2017-10-23 |
| RS56461B1 (sr) | 2018-01-31 |
| IL227669A0 (en) | 2013-09-30 |
| BR112013018898A2 (pt) | 2017-04-18 |
| AU2012209466A1 (en) | 2013-09-05 |
| JP6640275B2 (ja) | 2020-02-05 |
| LT2667715T (lt) | 2017-11-10 |
| HRP20171478T1 (hr) | 2017-11-17 |
| IL227669B (en) | 2020-06-30 |
| CY1119455T1 (el) | 2018-04-04 |
| WO2012102832A1 (en) | 2012-08-02 |
| ES2641880T3 (es) | 2017-11-14 |
| EP2667715B1 (en) | 2017-07-19 |
| US20140147491A1 (en) | 2014-05-29 |
| JP6342459B2 (ja) | 2018-06-13 |
| US9212204B2 (en) | 2015-12-15 |
| PT2667715T (pt) | 2017-10-19 |
| JP2016210808A (ja) | 2016-12-15 |
| CA2823218C (en) | 2021-04-20 |
| CO6791613A2 (es) | 2013-11-14 |
| EP2667715A4 (en) | 2014-07-23 |
| CA2823218A1 (en) | 2012-08-02 |
| BR112013018898B1 (pt) | 2021-10-05 |
| JP6348283B2 (ja) | 2018-06-27 |
| AU2012209466C1 (en) | 2016-06-23 |
| AU2012209466B2 (en) | 2016-02-25 |
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