PL2667715T3 - Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowego - Google Patents
Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowegoInfo
- Publication number
- PL2667715T3 PL2667715T3 PL12739509T PL12739509T PL2667715T3 PL 2667715 T3 PL2667715 T3 PL 2667715T3 PL 12739509 T PL12739509 T PL 12739509T PL 12739509 T PL12739509 T PL 12739509T PL 2667715 T3 PL2667715 T3 PL 2667715T3
- Authority
- PL
- Poland
- Prior art keywords
- methylprolyl
- glycyl
- treatment
- glutamic acid
- autism spectrum
- Prior art date
Links
- 208000029560 autism spectrum disease Diseases 0.000 title 1
- BUSXWGRAOZQTEY-SDBXPKJASA-N trofinetide Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@]1(C)CCCN1C(=O)CN BUSXWGRAOZQTEY-SDBXPKJASA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161462141P | 2011-01-27 | 2011-01-27 | |
| US201161492248P | 2011-06-01 | 2011-06-01 | |
| EP12739509.3A EP2667715B1 (en) | 2011-01-27 | 2012-01-27 | Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid |
| PCT/US2012/000047 WO2012102832A1 (en) | 2011-01-27 | 2012-01-27 | Treatment of autism spectrum disorderes using glycyl-l-2-methylprolyl-l-glutamic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2667715T3 true PL2667715T3 (pl) | 2018-02-28 |
Family
ID=46581110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12739509T PL2667715T3 (pl) | 2011-01-27 | 2012-01-27 | Leczenie zaburzeń spektrum autystycznego z wykorzystaniem kwasu glicylo-l- 2-metyloprolilo-l-glutaminowego |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9708366B2 (pl) |
| EP (1) | EP2667715B1 (pl) |
| JP (3) | JP6348283B2 (pl) |
| AU (1) | AU2012209466C1 (pl) |
| BR (1) | BR112013018898B1 (pl) |
| CA (1) | CA2823218C (pl) |
| CO (1) | CO6791613A2 (pl) |
| CY (1) | CY1119455T1 (pl) |
| DK (1) | DK2667715T3 (pl) |
| ES (1) | ES2641880T3 (pl) |
| HR (1) | HRP20171478T1 (pl) |
| HU (1) | HUE036637T2 (pl) |
| IL (1) | IL227669B (pl) |
| LT (1) | LT2667715T (pl) |
| PL (1) | PL2667715T3 (pl) |
| PT (1) | PT2667715T (pl) |
| RS (1) | RS56461B1 (pl) |
| SI (1) | SI2667715T1 (pl) |
| SM (1) | SMT201700485T1 (pl) |
| WO (1) | WO2012102832A1 (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012102832A1 (en) * | 2011-01-27 | 2012-08-02 | Neuren Pharmaceuticals Limited | Treatment of autism spectrum disorderes using glycyl-l-2-methylprolyl-l-glutamic acid |
| WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| BR112015012506A2 (pt) * | 2012-11-28 | 2017-07-11 | Neuren Pharmaceuticals Ltd | tratamento de transtornos do espectro do autismo usando ácido glicil-l-2-metilprolil-l-glutâmico |
| HRP20201002T1 (hr) * | 2013-07-25 | 2020-10-16 | Neuren Pharmaceuticals Limited | Neuroprotektivni biciklički spojevi i metode za njihovo korištenje u tretmanu poremećaja autističnog spektra i neurorazvojnih poremećaja |
| ES2710198T3 (es) | 2013-09-23 | 2019-04-23 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Tripéptidos antiinflamatorios |
| CN106659704B (zh) * | 2014-06-06 | 2020-03-10 | 迪肯大学 | 治疗孤独症谱系障碍的药物和用途 |
| RU2608444C1 (ru) * | 2015-10-02 | 2017-01-18 | Закрытое Акционерное Общество "Алмаз Фарм" | Средство для лечения и профилактики расстройств аутистического спектра |
| JP6694216B2 (ja) | 2015-10-14 | 2020-05-13 | 学校法人 久留米大学 | グレリンを有効成分として含有するレット症候群（ｒｔｔ）の予防・治療剤 |
| US11972336B2 (en) | 2015-12-18 | 2024-04-30 | Cognoa, Inc. | Machine learning platform and system for data analysis |
| WO2017192906A1 (en) * | 2016-05-04 | 2017-11-09 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of rett syndrome |
| CN110192252A (zh) | 2016-11-14 | 2019-08-30 | 科格诺亚公司 | 用于评估发育状况并提供覆盖度和可靠性控制的方法和装置 |
| DK3570940T3 (da) | 2017-01-20 | 2024-02-19 | Prilenia Neurotherapeutics Ltd | Pridopidin til anvendelse i behandling af fragilt x-syndrom |
| CA3053245A1 (en) | 2017-02-09 | 2018-08-16 | Cognoa, Inc. | Platform and system for digital personalized medicine |
| CA3128037A1 (en) * | 2019-02-01 | 2020-08-06 | Revivo Therapeutics | Nomethiazoles as a treatment for rett syndrome |
| CA3134521A1 (en) * | 2019-03-22 | 2020-10-01 | Cognoa, Inc. | Personalized digital therapy methods and devices |
| EP4009962A4 (en) * | 2019-08-05 | 2023-08-09 | Neuren Pharmaceuticals Limited | Compositions of trofinetide |
| IL292617A (en) * | 2019-10-28 | 2022-07-01 | Acadia Pharm Inc | Preparations for the treatment of Rett syndrome |
| EP4138880A4 (en) * | 2020-04-24 | 2024-08-07 | New York University | Use of igf-2 for treatment of epileptic seizures |
| IT202100004964A1 (it) * | 2021-03-03 | 2022-09-03 | Univ Degli Studi Di Bari Aldo Moro | Agonisti del recettore fpr2 (formyl peptide receptor 2) e loro uso nel trattamento del disturbo dello spettro autistico. |
| US11827600B2 (en) * | 2021-07-12 | 2023-11-28 | Acadia Pharmaceuticals Inc. | Crystalline forms of trofinetide |
| CN114128672B (zh) * | 2021-11-21 | 2023-04-07 | 河南省儿童医院郑州儿童医院 | 一种孤独症大鼠模型的构建方法 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
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| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
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| US8637567B2 (en) | 2001-05-24 | 2014-01-28 | Neuren Pharmaceuticals Ltd. | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid |
| US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
| JP2004536069A (ja) * | 2001-05-24 | 2004-12-02 | ニューロンズ・リミテッド | Ｇｐｅ類縁体及びペプチドミメティック |
| US20070004641A1 (en) * | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
| US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
| US7863304B2 (en) | 2001-05-24 | 2011-01-04 | Neuren Pharmaceuticals Limited | Analogs of glycyl-prolyl-glutamate |
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| AU2005286943A1 (en) | 2004-09-20 | 2006-03-30 | Mount Sinai School Of Medicine | Use of memantine (NAMENDA) to treat autism, compulsivity, and impulsivity |
| EP1888618A4 (en) * | 2005-05-23 | 2009-07-15 | Neuren Pharmaceuticals Ltd | Analogs of glycyl-prolyl-glutamate |
| EP2001400B1 (en) | 2006-03-14 | 2014-05-07 | Neuren Pharmaceuticals Limited | Oral formulations of glycyl-2-methylprolyl-glutamate |
| GB0707127D0 (en) * | 2007-04-13 | 2007-05-23 | Zysis Ltd | Pharmaceutical compositions |
| AU2008262387A1 (en) * | 2007-06-08 | 2008-12-18 | Massachusetts Institute Of Technology | IGF for the treatment of Rett Syndrome and synaptic disorders |
| TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| JP2011529072A (ja) | 2008-07-24 | 2011-12-01 | セラヴァンス， インコーポレーテッド | 二重作用血圧降下薬 |
| KR20110114664A (ko) | 2009-01-16 | 2011-10-19 | 메사추세츠 인스티튜트 오브 테크놀로지 | 자폐 스펙트럼 장애의 진단 및 치료 |
| WO2011146109A2 (en) | 2010-05-17 | 2011-11-24 | Mount Sinai School Of Medicine | Methods and assays for treating subjects with shank3 deletion, mutation or reduced expression |
| WO2012102832A1 (en) * | 2011-01-27 | 2012-08-02 | Neuren Pharmaceuticals Limited | Treatment of autism spectrum disorderes using glycyl-l-2-methylprolyl-l-glutamic acid |
-
2012
- 2012-01-27 WO PCT/US2012/000047 patent/WO2012102832A1/en active Application Filing
- 2012-01-27 HR HRP20171478TT patent/HRP20171478T1/hr unknown
- 2012-01-27 US US13/699,087 patent/US9708366B2/en active Active
- 2012-01-27 ES ES12739509.3T patent/ES2641880T3/es active Active
- 2012-01-27 BR BR112013018898-7A patent/BR112013018898B1/pt active IP Right Grant
- 2012-01-27 SI SI201231075T patent/SI2667715T1/sl unknown
- 2012-01-27 SM SM20170485T patent/SMT201700485T1/it unknown
- 2012-01-27 EP EP12739509.3A patent/EP2667715B1/en active Active
- 2012-01-27 AU AU2012209466A patent/AU2012209466C1/en active Active
- 2012-01-27 CA CA2823218A patent/CA2823218C/en active Active
- 2012-01-27 PT PT127395093T patent/PT2667715T/pt unknown
- 2012-01-27 HU HUE12739509A patent/HUE036637T2/hu unknown
- 2012-01-27 LT LTEP12739509.3T patent/LT2667715T/lt unknown
- 2012-01-27 JP JP2013551979A patent/JP6348283B2/ja active Active
- 2012-01-27 DK DK12739509.3T patent/DK2667715T3/en active
- 2012-01-27 RS RS20171001A patent/RS56461B1/sr unknown
- 2012-01-27 PL PL12739509T patent/PL2667715T3/pl unknown
-
2013
- 2013-07-25 IL IL227669A patent/IL227669B/en active IP Right Grant
- 2013-08-23 CO CO13200227A patent/CO6791613A2/es not_active Application Discontinuation
-
2015
- 2015-01-26 US US14/605,420 patent/US9212204B2/en active Active
-
2016
- 2016-09-09 JP JP2016176567A patent/JP6342459B2/ja active Active
-
2017
- 2017-10-12 CY CY20171101074T patent/CY1119455T1/el unknown
-
2018
- 2018-05-16 JP JP2018094320A patent/JP6640275B2/ja active Active
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