CH654571A5 - Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen. - Google Patents

Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen. Download PDF

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Publication number
CH654571A5
CH654571A5 CH404/83A CH40483A CH654571A5 CH 654571 A5 CH654571 A5 CH 654571A5 CH 404/83 A CH404/83 A CH 404/83A CH 40483 A CH40483 A CH 40483A CH 654571 A5 CH654571 A5 CH 654571A5
Authority
CH
Switzerland
Prior art keywords
urea
benzyl
butyl
formula
dimethylphenyl
Prior art date
Application number
CH404/83A
Other languages
German (de)
English (en)
Inventor
Vern Gordon Devries
Elwood Eugene Largis
Ransom Brown Conrow
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of CH654571A5 publication Critical patent/CH654571A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CH404/83A 1982-01-26 1983-01-25 Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen. CH654571A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (1)

Publication Number Publication Date
CH654571A5 true CH654571A5 (de) 1986-02-28

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
CH404/83A CH654571A5 (de) 1982-01-26 1983-01-25 Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen.

Country Status (20)

Country Link
KR (1) KR890001808B1 (fr)
AT (1) AT391313B (fr)
AU (1) AU562699B2 (fr)
CH (1) CH654571A5 (fr)
DE (1) DE3247581A1 (fr)
DK (1) DK160869C (fr)
ES (2) ES519246A0 (fr)
FI (1) FI85013C (fr)
FR (1) FR2521134B1 (fr)
GB (1) GB2113684B (fr)
GR (1) GR77186B (fr)
HU (1) HU200746B (fr)
IE (1) IE54683B1 (fr)
IL (1) IL67417A (fr)
IT (1) IT1203647B (fr)
NL (1) NL8300269A (fr)
NO (1) NO158417C (fr)
PL (1) PL143836B1 (fr)
PT (1) PT76138A (fr)
SE (1) SE462653B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
ES2060682T3 (es) * 1988-03-30 1994-12-01 Warner Lambert Co N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
CA2076012A1 (fr) * 1990-02-14 1991-08-15 Yasuyuki Kato Agent inhibiteur de la formation de ldl denatures
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
CA2115915A1 (fr) * 1992-07-20 1994-02-03 Kenji Hayashi Derives du benzene
WO1999007672A1 (fr) * 1997-08-05 1999-02-18 Novo Nordisk A/S Derivees d'anilines 2,5- et 3,5-disubstituees, leur preparation et utilisation
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
EP0975589A2 (fr) * 1998-01-21 2000-02-02 ZymoGenetics, Inc. Dialkylurees utilisees en tant que substances imitant la calcitonine
EP2176247A2 (fr) * 2007-07-10 2010-04-21 Amgen Inc. Dérivés de l'urée et de diamines associées, leurs procédés de fabrication, et leurs utilisations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL212631A (fr) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
ATA23983A (de) 1990-03-15
PL240284A1 (en) 1985-01-02
FI85013C (fi) 1992-02-25
DE3247581A1 (de) 1983-08-04
PL143836B1 (en) 1988-03-31
KR890001808B1 (ko) 1989-05-23
SE8300370D0 (sv) 1983-01-25
IT8347605A0 (it) 1983-01-25
ES531508A0 (es) 1985-07-01
GB2113684A (en) 1983-08-10
FI830247L (fi) 1983-07-27
NO158417B (no) 1988-05-30
GB8301863D0 (en) 1983-02-23
ES8406422A1 (es) 1984-08-01
AT391313B (de) 1990-09-25
SE8300370L (sv) 1983-07-27
DK28683D0 (da) 1983-01-25
DK160869B (da) 1991-04-29
AU562699B2 (en) 1987-06-18
IE830146L (en) 1983-07-26
NO830238L (no) 1983-07-27
SE462653B (sv) 1990-08-06
HU200746B (en) 1990-08-28
GR77186B (fr) 1984-09-11
DK160869C (da) 1991-10-14
PT76138A (en) 1983-02-01
AU1068183A (en) 1983-08-04
FR2521134A1 (fr) 1983-08-12
DK28683A (da) 1983-07-27
IE54683B1 (en) 1990-01-03
NO158417C (no) 1988-09-07
IT1203647B (it) 1989-02-15
FI830247A0 (fi) 1983-01-25
KR840002773A (ko) 1984-07-16
NL8300269A (nl) 1983-08-16
GB2113684B (en) 1985-12-18
ES8505943A1 (es) 1985-07-01
FR2521134B1 (fr) 1987-01-09
FI85013B (fi) 1991-11-15
ES519246A0 (es) 1984-08-01
IL67417A (en) 1989-10-31

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