FR2521134B1 - Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux - Google Patents

Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux

Info

Publication number
FR2521134B1
FR2521134B1 FR8301082A FR8301082A FR2521134B1 FR 2521134 B1 FR2521134 B1 FR 2521134B1 FR 8301082 A FR8301082 A FR 8301082A FR 8301082 A FR8301082 A FR 8301082A FR 2521134 B1 FR2521134 B1 FR 2521134B1
Authority
FR
France
Prior art keywords
ureas
atherosclerus
thio
drugs
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8301082A
Other languages
English (en)
Other versions
FR2521134A1 (fr
Inventor
Vern Gordon Devries
Elwood Eugene Largis
Ransom Brown Conrow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2521134A1 publication Critical patent/FR2521134A1/fr
Application granted granted Critical
Publication of FR2521134B1 publication Critical patent/FR2521134B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
FR8301082A 1982-01-26 1983-01-25 Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux Expired FR2521134B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (2)

Publication Number Publication Date
FR2521134A1 FR2521134A1 (fr) 1983-08-12
FR2521134B1 true FR2521134B1 (fr) 1987-01-09

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8301082A Expired FR2521134B1 (fr) 1982-01-26 1983-01-25 Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux

Country Status (20)

Country Link
KR (1) KR890001808B1 (fr)
AT (1) AT391313B (fr)
AU (1) AU562699B2 (fr)
CH (1) CH654571A5 (fr)
DE (1) DE3247581A1 (fr)
DK (1) DK160869C (fr)
ES (2) ES519246A0 (fr)
FI (1) FI85013C (fr)
FR (1) FR2521134B1 (fr)
GB (1) GB2113684B (fr)
GR (1) GR77186B (fr)
HU (1) HU200746B (fr)
IE (1) IE54683B1 (fr)
IL (1) IL67417A (fr)
IT (1) IT1203647B (fr)
NL (1) NL8300269A (fr)
NO (1) NO158417C (fr)
PL (1) PL143836B1 (fr)
PT (1) PT76138A (fr)
SE (1) SE462653B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
ES2060682T3 (es) * 1988-03-30 1994-12-01 Warner Lambert Co N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
AU7317391A (en) * 1990-02-14 1991-09-03 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
EP0609457B1 (fr) * 1992-07-20 1997-10-29 Eisai Co., Ltd. Derive du benzene
AU8534198A (en) * 1997-08-05 1999-03-01 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
EP0975589A2 (fr) * 1998-01-21 2000-02-02 ZymoGenetics, Inc. Dialkylurees utilisees en tant que substances imitant la calcitonine
JP5504484B2 (ja) * 2007-07-10 2014-05-28 アムジエン・インコーポレーテツド ウレア誘導体および関連ジアミン、これらの製造方法および使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (fr) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
GB2113684A (en) 1983-08-10
DK160869B (da) 1991-04-29
FI830247A0 (fi) 1983-01-25
DK28683A (da) 1983-07-27
AU1068183A (en) 1983-08-04
SE8300370L (sv) 1983-07-27
GR77186B (fr) 1984-09-11
PT76138A (en) 1983-02-01
KR840002773A (ko) 1984-07-16
AU562699B2 (en) 1987-06-18
ATA23983A (de) 1990-03-15
ES531508A0 (es) 1985-07-01
KR890001808B1 (ko) 1989-05-23
FI830247L (fi) 1983-07-27
ES8406422A1 (es) 1984-08-01
AT391313B (de) 1990-09-25
PL143836B1 (en) 1988-03-31
IT8347605A0 (it) 1983-01-25
ES519246A0 (es) 1984-08-01
IT1203647B (it) 1989-02-15
PL240284A1 (en) 1985-01-02
SE462653B (sv) 1990-08-06
IL67417A (en) 1989-10-31
IE54683B1 (en) 1990-01-03
GB2113684B (en) 1985-12-18
FR2521134A1 (fr) 1983-08-12
DE3247581A1 (de) 1983-08-04
DK28683D0 (da) 1983-01-25
FI85013B (fi) 1991-11-15
HU200746B (en) 1990-08-28
NO158417B (no) 1988-05-30
GB8301863D0 (en) 1983-02-23
SE8300370D0 (sv) 1983-01-25
IE830146L (en) 1983-07-26
CH654571A5 (de) 1986-02-28
NO830238L (no) 1983-07-27
NO158417C (no) 1988-09-07
FI85013C (fi) 1992-02-25
NL8300269A (nl) 1983-08-16
ES8505943A1 (es) 1985-07-01
DK160869C (da) 1991-10-14

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Legal Events

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