FR2349587A1 - 1,3-dihydro-heteroarylspiro(isobenzofurannes), leur procede de preparation et leur application therapeutique - Google Patents

1,3-dihydro-heteroarylspiro(isobenzofurannes), leur procede de preparation et leur application therapeutique

Info

Publication number
FR2349587A1
FR2349587A1 FR7713019A FR7713019A FR2349587A1 FR 2349587 A1 FR2349587 A1 FR 2349587A1 FR 7713019 A FR7713019 A FR 7713019A FR 7713019 A FR7713019 A FR 7713019A FR 2349587 A1 FR2349587 A1 FR 2349587A1
Authority
FR
France
Prior art keywords
isobenzofurannes
heteroarylspiro
dihydro
preparation process
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7713019A
Other languages
English (en)
Other versions
FR2349587B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2349587A1 publication Critical patent/FR2349587A1/fr
Application granted granted Critical
Publication of FR2349587B1 publication Critical patent/FR2349587B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
FR7713019A 1976-04-29 1977-04-29 1,3-dihydro-heteroarylspiro(isobenzofurannes), leur procede de preparation et leur application therapeutique Granted FR2349587A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/681,509 US4031224A (en) 1976-04-29 1976-04-29 1,3-Dihydro-heteroarylspiro (isobenzofuran)s

Publications (2)

Publication Number Publication Date
FR2349587A1 true FR2349587A1 (fr) 1977-11-25
FR2349587B1 FR2349587B1 (fr) 1980-03-07

Family

ID=24735573

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7713019A Granted FR2349587A1 (fr) 1976-04-29 1977-04-29 1,3-dihydro-heteroarylspiro(isobenzofurannes), leur procede de preparation et leur application therapeutique

Country Status (22)

Country Link
US (1) US4031224A (fr)
JP (1) JPS52133974A (fr)
AT (1) AT368502B (fr)
AU (1) AU517471B2 (fr)
BE (1) BE854133A (fr)
CA (1) CA1084493A (fr)
DE (1) DE2718455A1 (fr)
DK (1) DK185977A (fr)
ES (1) ES458127A1 (fr)
FI (1) FI771337A (fr)
FR (1) FR2349587A1 (fr)
GB (1) GB1571077A (fr)
GR (1) GR71645B (fr)
IE (1) IE45037B1 (fr)
IL (1) IL51957A0 (fr)
IT (1) IT1113573B (fr)
LU (1) LU77215A1 (fr)
NL (1) NL7704425A (fr)
NO (1) NO771442L (fr)
PT (1) PT66492B (fr)
SE (1) SE7704857L (fr)
ZA (1) ZA772548B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027522A1 (fr) * 1979-09-06 1981-04-29 Hoechst-Roussel Pharmaceuticals Incorporated Spiro(cyclohexane-1,1'(3'H)-isobenzofurane)s, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409229A (en) * 1977-12-02 1983-10-11 Hoechst-Roussel Pharmaceuticals, Inc. Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
PT70856B (en) * 1979-02-22 1981-06-11 Wellcome Found Imidazole derivatives and salts thereof their synthesis and pharmaceutical formulations
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
CA2037287A1 (fr) * 1990-03-02 1991-09-03 Ben E. Evans Antagonistes de l'oxytocine spirocyclique
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
CA2291674A1 (fr) * 1997-05-29 1998-12-03 Eli Lilly And Company Antagonistes de 5-ht1a et 5-ht1d.alpha.
US6376505B1 (en) 1997-05-29 2002-04-23 Eli Lilly And Company 5-HT1A and 5-HT1Dαdalpha antagonists
US8785634B2 (en) * 2010-04-26 2014-07-22 Merck Sharp & Dohme Corp Spiropiperidine prolylcarboxypeptidase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US3980787A (en) * 1975-08-25 1976-09-14 American Hoechst Corporation 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027522A1 (fr) * 1979-09-06 1981-04-29 Hoechst-Roussel Pharmaceuticals Incorporated Spiro(cyclohexane-1,1'(3'H)-isobenzofurane)s, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ATA302677A (de) 1982-02-15
IT1113573B (it) 1986-01-20
JPS52133974A (en) 1977-11-09
IE45037L (en) 1977-10-29
CA1084493A (fr) 1980-08-26
NL7704425A (nl) 1977-11-01
SE7704857L (sv) 1977-10-30
AU517471B2 (en) 1981-08-06
DE2718455A1 (de) 1977-11-10
NO771442L (no) 1977-11-01
LU77215A1 (fr) 1977-12-01
US4031224A (en) 1977-06-21
ZA772548B (en) 1978-04-26
IL51957A0 (en) 1977-06-30
AT368502B (de) 1982-10-25
PT66492B (de) 1978-12-14
FR2349587B1 (fr) 1980-03-07
FI771337A (fr) 1977-10-30
DK185977A (da) 1977-10-30
GB1571077A (en) 1980-07-09
BE854133A (fr) 1977-10-31
GR71645B (fr) 1983-06-29
PT66492A (de) 1977-05-01
IE45037B1 (en) 1982-06-02
AU2464777A (en) 1978-11-02
ES458127A1 (es) 1978-11-01

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