FR2340950A1 - Esters du cefuroxime, leur procede de preparation et leur application en therapeutique - Google Patents

Esters du cefuroxime, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2340950A1
FR2340950A1 FR7704339A FR7704339A FR2340950A1 FR 2340950 A1 FR2340950 A1 FR 2340950A1 FR 7704339 A FR7704339 A FR 7704339A FR 7704339 A FR7704339 A FR 7704339A FR 2340950 A1 FR2340950 A1 FR 2340950A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic application
cefuroxime
esters
cefuroxime esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7704339A
Other languages
English (en)
Other versions
FR2340950B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Glaxo Wellcome SA
Glaxo Laboratories Ltd
Original Assignee
Laboratoires Glaxo SA
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27254745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2340950(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB6009/76A external-priority patent/GB1571683A/en
Application filed by Laboratoires Glaxo SA, Glaxo Laboratories Ltd filed Critical Laboratoires Glaxo SA
Publication of FR2340950A1 publication Critical patent/FR2340950A1/fr
Application granted granted Critical
Publication of FR2340950B1 publication Critical patent/FR2340950B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7704339A 1976-02-16 1977-02-16 Esters du cefuroxime, leur procede de preparation et leur application en therapeutique Granted FR2340950A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB6009/76A GB1571683A (en) 1976-02-16 1976-02-16 Ester derivatives of cefuroxime
GB2730176 1976-06-30
GB2730276 1976-06-30

Publications (2)

Publication Number Publication Date
FR2340950A1 true FR2340950A1 (fr) 1977-09-09
FR2340950B1 FR2340950B1 (fr) 1980-02-01

Family

ID=27254745

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7704339A Granted FR2340950A1 (fr) 1976-02-16 1977-02-16 Esters du cefuroxime, leur procede de preparation et leur application en therapeutique

Country Status (16)

Country Link
US (1) US4267320A (fr)
JP (1) JPS52100494A (fr)
AT (1) AT358727B (fr)
AU (1) AU514236B2 (fr)
CA (1) CA1094545A (fr)
CH (2) CH628901A5 (fr)
CY (1) CY1181A (fr)
DE (1) DE2706413C2 (fr)
DK (1) DK149062C (fr)
FR (1) FR2340950A1 (fr)
HK (1) HK17185A (fr)
IL (1) IL51450A (fr)
KE (1) KE3260A (fr)
NL (2) NL185209C (fr)
SE (1) SE431986B (fr)
YU (1) YU40977B (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387988A1 (fr) * 1977-04-19 1978-11-17 Glaxo Lab Ltd Esters de cefuroxime, leur preparation et leur application therapeutique
FR2531087A1 (fr) * 1982-07-30 1984-02-03 Glaxo Group Ltd Nouvelle forme d'ester de cefuroxime, procede pour sa preparation et composition pharmaceutique la contenant
FR2549837A1 (fr) * 1983-07-29 1985-02-01 Glaxo Group Ltd Procede de preparation d'ester de 1-acetoxyethyle de cefuroxime
FR2591597A1 (fr) * 1985-09-30 1987-06-19 Glaxo Group Ltd Comprime pharmaceutique enrobe contenant de l'ester 1-acetoxyethylique de la cefuroxime et procede de preparation de celui-ci
FR2631031A1 (fr) * 1988-05-03 1989-11-10 Glaxo Group Ltd Procede de preparation de derives de cefuroxime et produits ainsi obtenus
FR2631032A1 (fr) * 1988-05-03 1989-11-10 Glaxo Group Ltd Procede de preparation de derives de cefuroxime et composes ainsi obtenus
EP0757991A1 (fr) * 1995-08-03 1997-02-12 ACS DOBFAR S.p.A. Forme cristalline de céfuroxime axétil biodisponible

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1093549A (fr) * 1976-02-16 1981-01-13 Michael Gregson Traduction non-disponible
GB1602736A (en) * 1977-08-12 1981-11-18 Glaxo Operations Ltd A-acetoxyethyl esters of 3-carbamoyloxymethyl-7-(2-(fur-2-yl)-2-methoxyiminoacetamido)ceph-3-em-4-carboxylic acids
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
JPH0586375U (ja) * 1991-07-11 1993-11-22 田中食品機械株式会社 ゴルフ練習用マット
JPH0541572U (ja) * 1991-11-15 1993-06-08 コナミ株式会社 遊戯機器用起伏形成装置
CN1111537C (zh) * 1997-05-15 2003-06-18 第一制糖株式会社 高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
IN186539B (fr) * 1997-09-29 2001-09-29 Ranbaxy Lab Ltd
ATE212638T1 (de) * 1998-02-20 2002-02-15 Fako Ilaclari A S Verfahren zur herstellung vom löslichen kristallinen cefuroxim axetil
US6384213B1 (en) 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
IN190831B (fr) 1999-03-19 2003-08-23 Ranbaxy Lab Ltd
WO2000056286A1 (fr) 1999-03-19 2000-09-28 Ranbaxy Laboratories Limited Procede de preparation d'une forme posologique orale biodisponible de cefuroxime axetil
CA2280925A1 (fr) 1999-07-29 2001-01-29 Bernard Charles Sherman Cefuroxime axetil stabilise
IN190849B (fr) * 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
DE60136229D1 (de) * 2001-07-25 2008-11-27 Lupin Ltd Verbessertes verfahren zur herstellung von cefuroxime axetil
ITMI20011763A1 (it) * 2001-08-10 2003-02-10 Antibioticos Spa Processo di preparazione di cefuroxime axelite ad elevata purezza
CZ12993U1 (cs) * 2001-11-23 2003-02-10 Glaxo Group Limited Farmaceutický prostředek
KR100552567B1 (ko) * 2003-08-23 2006-02-15 한국유나이티드제약 주식회사 수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법
CN1295234C (zh) * 2004-11-15 2007-01-17 中山大学 一种头孢呋辛酯非对映异构体的分离方法
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
DE102006019619A1 (de) * 2006-04-25 2007-10-31 Grünenthal GmbH Kristalline Modifikation von Cefuroximaxetil
WO2013038323A1 (fr) 2011-09-13 2013-03-21 Unimark Remedies Ltd. Compositions pharmaceutiques de céfuroxime axétil à goût masqué
CN111732599A (zh) * 2020-07-08 2020-10-02 江苏正大清江制药有限公司 一种合成头孢呋辛酯二聚体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1310642A (en) 1970-11-09 1973-03-21 Pfizer Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins
US3870713A (en) * 1970-12-07 1975-03-11 Pfizer Phosphono substituted alkylcephalosporins
CA996929A (en) * 1971-04-05 1976-09-14 Kohzi Nakano Acyloxyalkyl ester derivatives of penicillin
US3974153A (en) * 1971-05-14 1976-08-10 Glaxo Laboratories Limited 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
BE794844A (fr) * 1972-02-24 1973-08-01 Pfizer Alpha-carboxy-2-thienylmethylpenicilline et alpha-carboxy-2-thienylmethylcephalosporine,leurs esters et leurs sels
PL98296B1 (pl) 1973-02-07 1978-04-29 Politechnika Gdanskapo Sposob otrzymywania estrow acetoksymetylowych cefalosporyn
US3962227A (en) * 1973-02-23 1976-06-08 Eli Lilly And Company 3-halo cephalosporins
AR207148A1 (es) * 1974-05-02 1976-09-15 Rhone Poulenc Ind Procedimiento para la preparacion de un nuevo derivado de la cefalosporina

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387988A1 (fr) * 1977-04-19 1978-11-17 Glaxo Lab Ltd Esters de cefuroxime, leur preparation et leur application therapeutique
FR2531087A1 (fr) * 1982-07-30 1984-02-03 Glaxo Group Ltd Nouvelle forme d'ester de cefuroxime, procede pour sa preparation et composition pharmaceutique la contenant
EP0107276A2 (fr) * 1982-07-30 1984-05-02 Glaxo Group Limited Forme d'ester de céfuroxime, procédé pour leur préparation et compositions les contenant
EP0107276A3 (en) * 1982-07-30 1985-03-06 Glaxo Group Limited Novel form of cefuroxime ester, process for its preparation and composition containing it
FR2549837A1 (fr) * 1983-07-29 1985-02-01 Glaxo Group Ltd Procede de preparation d'ester de 1-acetoxyethyle de cefuroxime
FR2591597A1 (fr) * 1985-09-30 1987-06-19 Glaxo Group Ltd Comprime pharmaceutique enrobe contenant de l'ester 1-acetoxyethylique de la cefuroxime et procede de preparation de celui-ci
FR2631031A1 (fr) * 1988-05-03 1989-11-10 Glaxo Group Ltd Procede de preparation de derives de cefuroxime et produits ainsi obtenus
FR2631032A1 (fr) * 1988-05-03 1989-11-10 Glaxo Group Ltd Procede de preparation de derives de cefuroxime et composes ainsi obtenus
EP0757991A1 (fr) * 1995-08-03 1997-02-12 ACS DOBFAR S.p.A. Forme cristalline de céfuroxime axétil biodisponible
US5677443A (en) * 1995-08-03 1997-10-14 Acs Dobfar S.P.A. Bioavailable crystalline form of cefuroxime axetil

Also Published As

Publication number Publication date
NL930073I1 (nl) 1993-09-16
NL185209B (nl) 1989-09-18
CH628901A5 (de) 1982-03-31
SE431986B (sv) 1984-03-12
IL51450A0 (en) 1977-04-29
AU514236B2 (en) 1981-01-29
DK63877A (da) 1977-08-17
JPS633868B2 (fr) 1988-01-26
DK149062B (da) 1986-01-06
AT358727B (de) 1980-09-25
NL930073I2 (nl) 1993-11-01
DE2706413C2 (de) 1986-08-28
KE3260A (en) 1983-03-25
AU2228877A (en) 1978-08-24
DK149062C (da) 1986-06-16
US4267320A (en) 1981-05-12
YU40977B (en) 1986-10-31
CA1094545A (fr) 1981-01-27
CH634328A5 (de) 1983-01-31
YU41177A (en) 1982-06-30
DE2706413A1 (de) 1977-08-18
FR2340950B1 (fr) 1980-02-01
NL7701568A (nl) 1977-08-18
ATA100677A (de) 1980-02-15
SE7701668L (sv) 1977-08-17
JPS52100494A (en) 1977-08-23
HK17185A (en) 1985-03-22
IL51450A (en) 1980-11-30
NL185209C (nl) 1990-02-16
CY1181A (en) 1983-10-07

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0182, 920511

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0182, 770216

CL Concession to grant licences