ATA302677A - Verfahren zur herstellung von neuen 1,3-dihydro- heteroarylspiro/isobenzofuran)en und von deren optischen antipoden und pharmazeutisch vertraeglichen saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen 1,3-dihydro- heteroarylspiro/isobenzofuran)en und von deren optischen antipoden und pharmazeutisch vertraeglichen saeureadditionssalzen

Info

Publication number
ATA302677A
ATA302677A AT773026A AT302677A ATA302677A AT A302677 A ATA302677 A AT A302677A AT 773026 A AT773026 A AT 773026A AT 302677 A AT302677 A AT 302677A AT A302677 A ATA302677 A AT A302677A
Authority
AT
Austria
Prior art keywords
dihydroheteroarylspiro
isobenzofurane
new
production
acid addition
Prior art date
Application number
AT773026A
Other languages
English (en)
Other versions
AT368502B (de
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ATA302677A publication Critical patent/ATA302677A/de
Application granted granted Critical
Publication of AT368502B publication Critical patent/AT368502B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
AT0302677A 1976-04-29 1977-04-28 Verfahren zur herstellung von neuen 1,3-dihydro- heteroarylspiro(isobenzofuran)en und von deren optischen antipoden und pharmazeutisch vertraeglichen saeureadditionssalzen AT368502B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/681,509 US4031224A (en) 1976-04-29 1976-04-29 1,3-Dihydro-heteroarylspiro (isobenzofuran)s

Publications (2)

Publication Number Publication Date
ATA302677A true ATA302677A (de) 1982-02-15
AT368502B AT368502B (de) 1982-10-25

Family

ID=24735573

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0302677A AT368502B (de) 1976-04-29 1977-04-28 Verfahren zur herstellung von neuen 1,3-dihydro- heteroarylspiro(isobenzofuran)en und von deren optischen antipoden und pharmazeutisch vertraeglichen saeureadditionssalzen

Country Status (22)

Country Link
US (1) US4031224A (de)
JP (1) JPS52133974A (de)
AT (1) AT368502B (de)
AU (1) AU517471B2 (de)
BE (1) BE854133A (de)
CA (1) CA1084493A (de)
DE (1) DE2718455A1 (de)
DK (1) DK185977A (de)
ES (1) ES458127A1 (de)
FI (1) FI771337A (de)
FR (1) FR2349587A1 (de)
GB (1) GB1571077A (de)
GR (1) GR71645B (de)
IE (1) IE45037B1 (de)
IL (1) IL51957A0 (de)
IT (1) IT1113573B (de)
LU (1) LU77215A1 (de)
NL (1) NL7704425A (de)
NO (1) NO771442L (de)
PT (1) PT66492B (de)
SE (1) SE7704857L (de)
ZA (1) ZA772548B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409229A (en) * 1977-12-02 1983-10-11 Hoechst-Roussel Pharmaceuticals, Inc. Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
MC1315A1 (fr) * 1979-02-22 1981-03-10 Wellcome Found Derives de l'imidazole et leur synthese et preparation de medicaments contenant ces substances
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
EP0450761A1 (de) * 1990-03-02 1991-10-09 Merck & Co. Inc. Spirocyclische Oxtocin-Antagonisten
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
US6376505B1 (en) 1997-05-29 2002-04-23 Eli Lilly And Company 5-HT1A and 5-HT1Dαdalpha antagonists
WO1998053823A1 (en) * 1997-05-29 1998-12-03 Eli Lilly And Company 5-HT1A AND 5-HT1Dα ANTAGONISTS
WO2011137024A1 (en) * 2010-04-26 2011-11-03 Merck Sharp & Dohme Corp. Novel spiropiperidine prolylcarboxypeptidase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US3980787A (en) * 1975-08-25 1976-09-14 American Hoechst Corporation 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives

Also Published As

Publication number Publication date
US4031224A (en) 1977-06-21
IE45037L (en) 1977-10-29
IL51957A0 (en) 1977-06-30
DE2718455A1 (de) 1977-11-10
BE854133A (fr) 1977-10-31
PT66492A (de) 1977-05-01
ZA772548B (en) 1978-04-26
JPS52133974A (en) 1977-11-09
GR71645B (de) 1983-06-29
PT66492B (de) 1978-12-14
IT1113573B (it) 1986-01-20
NO771442L (no) 1977-11-01
FR2349587B1 (de) 1980-03-07
AT368502B (de) 1982-10-25
AU517471B2 (en) 1981-08-06
IE45037B1 (en) 1982-06-02
ES458127A1 (es) 1978-11-01
NL7704425A (nl) 1977-11-01
DK185977A (da) 1977-10-30
SE7704857L (sv) 1977-10-30
CA1084493A (en) 1980-08-26
GB1571077A (en) 1980-07-09
FI771337A (de) 1977-10-30
FR2349587A1 (fr) 1977-11-25
AU2464777A (en) 1978-11-02
LU77215A1 (de) 1977-12-01

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Legal Events

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ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee