BE854133A - 1,3-dihydro-heteroarylspito(isobenzofurannes)et leur procede de preparation et leur application therapeutique - Google Patents

1,3-dihydro-heteroarylspito(isobenzofurannes)et leur procede de preparation et leur application therapeutique

Info

Publication number
BE854133A
BE854133A BE177158A BE177158A BE854133A BE 854133 A BE854133 A BE 854133A BE 177158 A BE177158 A BE 177158A BE 177158 A BE177158 A BE 177158A BE 854133 A BE854133 A BE 854133A
Authority
BE
Belgium
Prior art keywords
isobenzofurannes
heteroarylspito
dihydro
preparation process
therapeutic application
Prior art date
Application number
BE177158A
Other languages
English (en)
French (fr)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BE854133A publication Critical patent/BE854133A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
BE177158A 1976-04-29 1977-04-29 1,3-dihydro-heteroarylspito(isobenzofurannes)et leur procede de preparation et leur application therapeutique BE854133A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/681,509 US4031224A (en) 1976-04-29 1976-04-29 1,3-Dihydro-heteroarylspiro (isobenzofuran)s

Publications (1)

Publication Number Publication Date
BE854133A true BE854133A (fr) 1977-10-31

Family

ID=24735573

Family Applications (1)

Application Number Title Priority Date Filing Date
BE177158A BE854133A (fr) 1976-04-29 1977-04-29 1,3-dihydro-heteroarylspito(isobenzofurannes)et leur procede de preparation et leur application therapeutique

Country Status (22)

Country Link
US (1) US4031224A (xx)
JP (1) JPS52133974A (xx)
AT (1) AT368502B (xx)
AU (1) AU517471B2 (xx)
BE (1) BE854133A (xx)
CA (1) CA1084493A (xx)
DE (1) DE2718455A1 (xx)
DK (1) DK185977A (xx)
ES (1) ES458127A1 (xx)
FI (1) FI771337A (xx)
FR (1) FR2349587A1 (xx)
GB (1) GB1571077A (xx)
GR (1) GR71645B (xx)
IE (1) IE45037B1 (xx)
IL (1) IL51957A0 (xx)
IT (1) IT1113573B (xx)
LU (1) LU77215A1 (xx)
NL (1) NL7704425A (xx)
NO (1) NO771442L (xx)
PT (1) PT66492B (xx)
SE (1) SE7704857L (xx)
ZA (1) ZA772548B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409229A (en) * 1977-12-02 1983-10-11 Hoechst-Roussel Pharmaceuticals, Inc. Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
GB2044259B (en) * 1979-02-22 1983-08-03 Wellcome Found Imidazole derivatives and salts thereof synthesis and pharmaceutical formulations
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
EP0450761A1 (en) * 1990-03-02 1991-10-09 Merck & Co. Inc. Spirocyclic oxytocin antagonists
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
WO1998053823A1 (en) * 1997-05-29 1998-12-03 Eli Lilly And Company 5-HT1A AND 5-HT1Dα ANTAGONISTS
US6376505B1 (en) 1997-05-29 2002-04-23 Eli Lilly And Company 5-HT1A and 5-HT1Dαdalpha antagonists
WO2011137024A1 (en) * 2010-04-26 2011-11-03 Merck Sharp & Dohme Corp. Novel spiropiperidine prolylcarboxypeptidase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US3980787A (en) * 1975-08-25 1976-09-14 American Hoechst Corporation 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives

Also Published As

Publication number Publication date
CA1084493A (en) 1980-08-26
IE45037L (en) 1977-10-29
NL7704425A (nl) 1977-11-01
IE45037B1 (en) 1982-06-02
NO771442L (no) 1977-11-01
AT368502B (de) 1982-10-25
PT66492A (de) 1977-05-01
ZA772548B (en) 1978-04-26
FI771337A (xx) 1977-10-30
ATA302677A (de) 1982-02-15
US4031224A (en) 1977-06-21
GR71645B (xx) 1983-06-29
PT66492B (de) 1978-12-14
IT1113573B (it) 1986-01-20
AU517471B2 (en) 1981-08-06
DE2718455A1 (de) 1977-11-10
IL51957A0 (en) 1977-06-30
DK185977A (da) 1977-10-30
FR2349587B1 (xx) 1980-03-07
LU77215A1 (xx) 1977-12-01
GB1571077A (en) 1980-07-09
SE7704857L (sv) 1977-10-30
AU2464777A (en) 1978-11-02
FR2349587A1 (fr) 1977-11-25
ES458127A1 (es) 1978-11-01
JPS52133974A (en) 1977-11-09

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