DK28683A - Fremgangsmaade til fremstilling af substituerede urinstoffer og thiourinstoffer - Google Patents

Fremgangsmaade til fremstilling af substituerede urinstoffer og thiourinstoffer Download PDF

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Publication number
DK28683A
DK28683A DK28683A DK28683A DK28683A DK 28683 A DK28683 A DK 28683A DK 28683 A DK28683 A DK 28683A DK 28683 A DK28683 A DK 28683A DK 28683 A DK28683 A DK 28683A
Authority
DK
Denmark
Prior art keywords
thiour
urines
ingredients
substituted
procedure
Prior art date
Application number
DK28683A
Other languages
English (en)
Other versions
DK160869C (da
DK160869B (da
DK28683D0 (da
Inventor
Vern Gordon Devries
Elwood Eugene Largis
Ransom Brown Conrow
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK28683D0 publication Critical patent/DK28683D0/da
Publication of DK28683A publication Critical patent/DK28683A/da
Publication of DK160869B publication Critical patent/DK160869B/da
Application granted granted Critical
Publication of DK160869C publication Critical patent/DK160869C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827X being H
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK028683A 1982-01-26 1983-01-25 Analogifremgangsmaade til fremstilling af substituerede urinstoffer og thiourinstoffer DK160869C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US34269382 1982-01-26
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US34269882 1982-01-26

Publications (4)

Publication Number Publication Date
DK28683D0 DK28683D0 (da) 1983-01-25
DK28683A true DK28683A (da) 1983-07-27
DK160869B DK160869B (da) 1991-04-29
DK160869C DK160869C (da) 1991-10-14

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
DK028683A DK160869C (da) 1982-01-26 1983-01-25 Analogifremgangsmaade til fremstilling af substituerede urinstoffer og thiourinstoffer

Country Status (20)

Country Link
KR (1) KR890001808B1 (da)
AT (1) AT391313B (da)
AU (1) AU562699B2 (da)
CH (1) CH654571A5 (da)
DE (1) DE3247581A1 (da)
DK (1) DK160869C (da)
ES (2) ES8406422A1 (da)
FI (1) FI85013C (da)
FR (1) FR2521134B1 (da)
GB (1) GB2113684B (da)
GR (1) GR77186B (da)
HU (1) HU200746B (da)
IE (1) IE54683B1 (da)
IL (1) IL67417A (da)
IT (1) IT1203647B (da)
NL (1) NL8300269A (da)
NO (1) NO158417C (da)
PL (1) PL143836B1 (da)
PT (1) PT76138A (da)
SE (1) SE462653B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
JPH0678298B2 (ja) * 1988-03-30 1994-10-05 ワーナー‐ランバート・コンパニー N‐〔〔(2,6‐ジ置換)フエニル〕‐n′‐アリールアルキル〕尿素
EP0515684A4 (en) * 1990-02-14 1993-04-21 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
EP0609457B1 (en) * 1992-07-20 1997-10-29 Eisai Co., Ltd. Benzene derivative
JP2003524574A (ja) * 1997-08-05 2003-08-19 ノボ ノルディスク アクティーゼルスカブ 2,5−及び3,5−二置換アニリン誘導体、その調製及び使用
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
WO1999037604A2 (en) * 1998-01-21 1999-07-29 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
US8324396B2 (en) * 2007-07-10 2012-12-04 Amgen Inc. Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (da) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
SE8300370L (sv) 1983-07-27
PT76138A (en) 1983-02-01
IL67417A (en) 1989-10-31
KR840002773A (ko) 1984-07-16
PL240284A1 (en) 1985-01-02
AU562699B2 (en) 1987-06-18
GB2113684B (en) 1985-12-18
FI85013B (fi) 1991-11-15
NO158417B (no) 1988-05-30
CH654571A5 (de) 1986-02-28
FI85013C (fi) 1992-02-25
DK160869C (da) 1991-10-14
AU1068183A (en) 1983-08-04
DE3247581A1 (de) 1983-08-04
IE830146L (en) 1983-07-26
GB2113684A (en) 1983-08-10
SE462653B (sv) 1990-08-06
SE8300370D0 (sv) 1983-01-25
ES531508A0 (es) 1985-07-01
NO830238L (no) 1983-07-27
DK160869B (da) 1991-04-29
GR77186B (da) 1984-09-11
DK28683D0 (da) 1983-01-25
GB8301863D0 (en) 1983-02-23
ATA23983A (de) 1990-03-15
FI830247A0 (fi) 1983-01-25
NO158417C (no) 1988-09-07
HU200746B (en) 1990-08-28
ES8505943A1 (es) 1985-07-01
PL143836B1 (en) 1988-03-31
IT1203647B (it) 1989-02-15
FI830247L (fi) 1983-07-27
NL8300269A (nl) 1983-08-16
FR2521134A1 (fr) 1983-08-12
IE54683B1 (en) 1990-01-03
AT391313B (de) 1990-09-25
ES519246A0 (es) 1984-08-01
ES8406422A1 (es) 1984-08-01
KR890001808B1 (ko) 1989-05-23
FR2521134B1 (fr) 1987-01-09
IT8347605A0 (it) 1983-01-25

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