KR840002773A - 치환우레아 및 티오우레아류의 제조방법 - Google Patents

치환우레아 및 티오우레아류의 제조방법 Download PDF

Info

Publication number
KR840002773A
KR840002773A KR1019820005843A KR820005843A KR840002773A KR 840002773 A KR840002773 A KR 840002773A KR 1019820005843 A KR1019820005843 A KR 1019820005843A KR 820005843 A KR820005843 A KR 820005843A KR 840002773 A KR840002773 A KR 840002773A
Authority
KR
South Korea
Prior art keywords
formula
compound
phenoxy
group
halo
Prior art date
Application number
KR1019820005843A
Other languages
English (en)
Other versions
KR890001808B1 (ko
Inventor
고오든 데브리이즈 버언 (외 2)
Original Assignee
죤 제이 헤이간
아메리칸 사이아나밋드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by 죤 제이 헤이간, 아메리칸 사이아나밋드 캄파니 filed Critical 죤 제이 헤이간
Publication of KR840002773A publication Critical patent/KR840002773A/ko
Application granted granted Critical
Publication of KR890001808B1 publication Critical patent/KR890001808B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음.

Description

치환우레아 및 티오우레아류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 구조식(III)의 아릴이소시아네이트 또는 아릴티오이소시아네이트를 하기 구조식(IV)의 2급 아민과 반응시키는 것으로 구성된 하기 구조식(II)의 화합물을 제조하는 방법.
    상기 식들에서, X는 수소, C1-C4알케닌, C1-C4알키닐, 하이드록시, C1-C4알콕시, 펜옥시, 메르캅토, C1-C4알킬디오, 아미노, C1-C4알킬아미노, 디-(C2-C4알킬)-아미노, 할로, 트리할로메틴, C1-C4알카노일, 벤조일, C1-C4알칸아미도, C1-C4알칸설포닐, C1-C4알칸설피닐, 벤젠설포닐, 톨루엔설포닐, 니트로, 시아노, 카복시, C1-C4카보알콕시, 카바모일, 설파밀, 메틸랜디옥시, 페닐, 오르토-페닐랜톨릴, 벤질, 할로벤질, 메틸벤질 및 기로 구성된 군으로부터 선택된 적어도 하나의 치환분이며(Y는 산소 및 유황으로 구성된 군으로부터 선택되며);R1과 R2는 동일 또는 상이한 것으로 C4-C12알킬, C4-C12알케닐, C4-C12알키닐, C4-C12사이클로알킬, C4-C12사이클로알킬알킬, C4-C14아르알킬, C7-C14아르알킬로 구성된 군으로부터 독립적으로 선택되며, 여기서 방향족환은 C1-C10알킬, C1-C4알콕시, 펜옥시, 벤질옥시, 메틸랜디옥시, C1-C4알킬티오, 페닐, 할로, 트리할로메틸, 아다만틸, C1-C4카보알콕시 및 니트로로 구성된 군으로부터 선택된 적어도 하나의 치환분을 함유하며; R3는 수소이다.
  2. 하기 구조식(V)의 화합물을 하기 구조식(IV)의 2급 아민과 반응시켜 하기 구조식(VI)의 중간체를 얻고 이 중간체를 하기 구조식(VI)의 아릴아민과 반응시키는 것으로 구성된 제1항에서와 같은 화합물을 제조하는 방법.
    상기 식들에서 Y, R1, R2, X, R3는 1항에서 정의한 바와 같으며 A와 B는 할로, C1-C4알콕시, C1-C4알킬티오, 펜옥시, 4-클로로펜옥시, 4-니트로펜옥시로 구성된 군으로부터 독립적으로 선택된다.
  3. 하기 구조식(V)의 화합물을 하기 구조식(VII)의 아릴아민과 반응시켜 하기 구조식(VIII)의 중간체를 얻고 이 중간체를 하기 구조식(IV)의 2급 아민과 반응시키는 것으로 구성된 제1항에서와 같은 화합물을 제조하는 방법.
    상기 식들에서 Y, X, R3, R1및 R2는 제1항에서 정의한 바와 같으며, A와 B는 할로, C1-C4알콕시, C1-C4알킬티오, 펜옥시, 4-클로로펜옥시, 4-니트로펜옥시로 구성된 군으로부터 독립적으로 선택된다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8205843A 1982-01-26 1982-12-28 우레아 및 티오우레아류의 제조방법 KR890001808B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US342693 1982-01-26
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US342.693 1982-01-26
US342.698 1982-01-26
US342698 1994-11-21

Publications (2)

Publication Number Publication Date
KR840002773A true KR840002773A (ko) 1984-07-16
KR890001808B1 KR890001808B1 (ko) 1989-05-23

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205843A KR890001808B1 (ko) 1982-01-26 1982-12-28 우레아 및 티오우레아류의 제조방법

Country Status (20)

Country Link
KR (1) KR890001808B1 (ko)
AT (1) AT391313B (ko)
AU (1) AU562699B2 (ko)
CH (1) CH654571A5 (ko)
DE (1) DE3247581A1 (ko)
DK (1) DK160869C (ko)
ES (2) ES519246A0 (ko)
FI (1) FI85013C (ko)
FR (1) FR2521134B1 (ko)
GB (1) GB2113684B (ko)
GR (1) GR77186B (ko)
HU (1) HU200746B (ko)
IE (1) IE54683B1 (ko)
IL (1) IL67417A (ko)
IT (1) IT1203647B (ko)
NL (1) NL8300269A (ko)
NO (1) NO158417C (ko)
PL (1) PL143836B1 (ko)
PT (1) PT76138A (ko)
SE (1) SE462653B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
ES2060682T3 (es) * 1988-03-30 1994-12-01 Warner Lambert Co N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
CA2076012A1 (en) * 1990-02-14 1991-08-15 Yasuyuki Kato Agent for inhibiting the formation of denatured ldl
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
CA2115915A1 (en) * 1992-07-20 1994-02-03 Kenji Hayashi Benzene derivatives
WO1999007672A1 (en) * 1997-08-05 1999-02-18 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
EP0975589A2 (en) * 1998-01-21 2000-02-02 ZymoGenetics, Inc. Dialkyl ureas as calcitonin mimetics
EP2176247A2 (en) * 2007-07-10 2010-04-21 Amgen Inc. Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL212631A (ko) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
ATA23983A (de) 1990-03-15
PL240284A1 (en) 1985-01-02
FI85013C (fi) 1992-02-25
DE3247581A1 (de) 1983-08-04
PL143836B1 (en) 1988-03-31
KR890001808B1 (ko) 1989-05-23
SE8300370D0 (sv) 1983-01-25
IT8347605A0 (it) 1983-01-25
ES531508A0 (es) 1985-07-01
GB2113684A (en) 1983-08-10
FI830247L (fi) 1983-07-27
NO158417B (no) 1988-05-30
GB8301863D0 (en) 1983-02-23
ES8406422A1 (es) 1984-08-01
AT391313B (de) 1990-09-25
SE8300370L (sv) 1983-07-27
DK28683D0 (da) 1983-01-25
DK160869B (da) 1991-04-29
AU562699B2 (en) 1987-06-18
IE830146L (en) 1983-07-26
NO830238L (no) 1983-07-27
SE462653B (sv) 1990-08-06
HU200746B (en) 1990-08-28
GR77186B (ko) 1984-09-11
DK160869C (da) 1991-10-14
PT76138A (en) 1983-02-01
AU1068183A (en) 1983-08-04
CH654571A5 (de) 1986-02-28
FR2521134A1 (fr) 1983-08-12
DK28683A (da) 1983-07-27
IE54683B1 (en) 1990-01-03
NO158417C (no) 1988-09-07
IT1203647B (it) 1989-02-15
FI830247A0 (fi) 1983-01-25
NL8300269A (nl) 1983-08-16
GB2113684B (en) 1985-12-18
ES8505943A1 (es) 1985-07-01
FR2521134B1 (fr) 1987-01-09
FI85013B (fi) 1991-11-15
ES519246A0 (es) 1984-08-01
IL67417A (en) 1989-10-31

Similar Documents

Publication Publication Date Title
KR840002773A (ko) 치환우레아 및 티오우레아류의 제조방법
DK99186A (da) Phenylcarbamater
JPS5356670A (en) N-benzoyl-n&#39;-pyridyloxyphenyl urea compounds, process for preparation ofthe same, and insecticides containing the same as active constituents
ES2056071T3 (es) Triazolinonas substituidas.
IL69901A0 (en) N-(cyclopropyl-triazinyl and-pyrimidinyl)-n&#39;-(arylsulfonyl) ureas,their preparation and their use as herbicides and plant growth regulants
CA2064636A1 (en) Sulphonylaminocarbonyltriazolinones having substituents bonded via oxygen
EP0246749A3 (en) Triazole herbicides
ES2161955T3 (es) Benzofuranil-ureas sustituidas con heterociclilcarbonilo.
DK0640081T3 (da) Substituerede phenylcarbarmater og phenylurinstoffer, deres fremstilling og deres anvendelse som 5-HT4-antagonister
AR245108A1 (es) Derivados de n-(2-nitrofenil)-n-pirimidina-2-il-urea. su obtencion e intermediarios, composiciones herbicidas y reguladoras del crecimiento de las plantas que los contienen.
ES484784A1 (es) Procedimiento para la obtencion de n-benzoil-n&#39;-terc.-alco- xicarbonilfenil-(tio)ureas sustituidas, de efecto insectici-da
DK412782A (da) Substituerede phenylurinstofderivater, deres fremstilling og mellemprodukter hertil samt deres anvendelse som herbicider
ATE8134T1 (de) N-benzoyl-n&#39;-phenylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von insekten.
EP0129408A3 (en) (3-alkyl-5-isothiazolyl)ureas
ES8402566A1 (es) Procedimiento para preparar fenilsulfonilisocianatos sustituidos.
IL71361A (en) 3-(pyrimidin-5-yl-oxyphenyl)-1-benzoyl(thio)ureas,processes for their preparation and pesticidal compositions containing them
ATE16926T1 (de) N-benzoyl-n&#39;-phenoxyphenylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen.
RU92004529A (ru) Производные 2-азабицикло /2,2,1/гепт-5-ен-2-уксусной кислоты
DE3460326D1 (en) Binder for cationically electrodepositable coating
IT1149846B (it) Processo per la sintesi di 1-ammino-3-p(b-metossi-etil)-fenosi-2-propanolo
FR2528040B1 (ko)
ES8306998A1 (es) Procedimiento para la obtencion de o-pirazol-4-il-carbamatos n-sustituidos.
ES2001701A6 (es) Un metodo para preparar compuesto de benzoilurea
ATE63540T1 (de) N-benzoyl-,n&#39;-phenoxyphenylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen.
ATE16099T1 (de) Verfahren zur herstellung von n-substituierten n- isocyanatocarbonyl-carbamaten.