IT1203647B - Uree e tiouree sostituite aventi attivita' antiaterosclerotica,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono - Google Patents
Uree e tiouree sostituite aventi attivita' antiaterosclerotica,procedimento per la loro preparazione e composizioni farmaceutiche che le contengonoInfo
- Publication number
- IT1203647B IT1203647B IT47605/83A IT4760583A IT1203647B IT 1203647 B IT1203647 B IT 1203647B IT 47605/83 A IT47605/83 A IT 47605/83A IT 4760583 A IT4760583 A IT 4760583A IT 1203647 B IT1203647 B IT 1203647B
- Authority
- IT
- Italy
- Prior art keywords
- thiouras
- therosclerotic
- ureas
- activities
- replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Furan Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
US06/342,698 US4387105A (en) | 1982-01-26 | 1982-01-26 | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8347605A0 IT8347605A0 (it) | 1983-01-25 |
IT1203647B true IT1203647B (it) | 1989-02-15 |
Family
ID=26993144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT47605/83A IT1203647B (it) | 1982-01-26 | 1983-01-25 | Uree e tiouree sostituite aventi attivita' antiaterosclerotica,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono |
Country Status (20)
Country | Link |
---|---|
KR (1) | KR890001808B1 (fr) |
AT (1) | AT391313B (fr) |
AU (1) | AU562699B2 (fr) |
CH (1) | CH654571A5 (fr) |
DE (1) | DE3247581A1 (fr) |
DK (1) | DK160869C (fr) |
ES (2) | ES519246A0 (fr) |
FI (1) | FI85013C (fr) |
FR (1) | FR2521134B1 (fr) |
GB (1) | GB2113684B (fr) |
GR (1) | GR77186B (fr) |
HU (1) | HU200746B (fr) |
IE (1) | IE54683B1 (fr) |
IL (1) | IL67417A (fr) |
IT (1) | IT1203647B (fr) |
NL (1) | NL8300269A (fr) |
NO (1) | NO158417C (fr) |
PL (1) | PL143836B1 (fr) |
PT (1) | PT76138A (fr) |
SE (1) | SE462653B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2138804A (en) * | 1983-04-27 | 1984-10-31 | Sumitomo Chemical Co | Fungicidal N-phenylcarbamates |
GB2149394B (en) * | 1983-07-19 | 1986-09-24 | American Cyanamid Co | Ureas |
US4818899A (en) * | 1986-12-03 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Second harmonic generation by carbamic acid derivatives |
ES2060682T3 (es) * | 1988-03-30 | 1994-12-01 | Warner Lambert Co | N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos. |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
CA2076012A1 (fr) * | 1990-02-14 | 1991-08-15 | Yasuyuki Kato | Agent inhibiteur de la formation de ldl denatures |
US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
CA2115915A1 (fr) * | 1992-07-20 | 1994-02-03 | Kenji Hayashi | Derives du benzene |
WO1999007672A1 (fr) * | 1997-08-05 | 1999-02-18 | Novo Nordisk A/S | Derivees d'anilines 2,5- et 3,5-disubstituees, leur preparation et utilisation |
TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
US6455566B1 (en) | 1997-09-03 | 2002-09-24 | Wyeth | Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents |
EP0975589A2 (fr) * | 1998-01-21 | 2000-02-02 | ZymoGenetics, Inc. | Dialkylurees utilisees en tant que substances imitant la calcitonine |
EP2176247A2 (fr) * | 2007-07-10 | 2010-04-21 | Amgen Inc. | Dérivés de l'urée et de diamines associées, leurs procédés de fabrication, et leurs utilisations |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL212631A (fr) * | 1949-12-06 | |||
US2688039A (en) * | 1952-02-08 | 1954-08-31 | Ciba Pharm Prod Inc | Halogen-containing di-(substituted phenyl)-thioureas |
US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
US3335142A (en) * | 1965-07-07 | 1967-08-08 | American Cyanamid Co | Process for the preparation of n, n'-disubstituted ureas |
US3659012A (en) * | 1969-05-26 | 1972-04-25 | Lilly Co Eli | Methods of treating helminth infections with thiourea derivatives |
US3728386A (en) * | 1970-07-27 | 1973-04-17 | Exxon Research Engineering Co | N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides |
US3928437A (en) * | 1970-09-02 | 1975-12-23 | Ciba Geigy Corp | Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas |
US3856952A (en) * | 1973-03-01 | 1974-12-24 | Pennwalt Corp | Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides |
US3903130A (en) * | 1974-05-03 | 1975-09-02 | Stauffer Chemical Co | 1-Trifluormethylphenyl-3-dicyanophenyl urea |
DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
-
1982
- 1982-12-05 IL IL67417A patent/IL67417A/xx not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/de not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/ko active
-
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 PL PL1983240284A patent/PL143836B1/pl unknown
- 1983-01-25 NO NO830238A patent/NO158417C/no unknown
- 1983-01-25 NL NL8300269A patent/NL8300269A/nl not_active Application Discontinuation
- 1983-01-25 HU HU83227A patent/HU200746B/hu not_active IP Right Cessation
- 1983-01-25 FR FR8301082A patent/FR2521134B1/fr not_active Expired
- 1983-01-25 CH CH404/83A patent/CH654571A5/de not_active IP Right Cessation
- 1983-01-25 IT IT47605/83A patent/IT1203647B/it active
- 1983-01-25 AT AT0023983A patent/AT391313B/de not_active IP Right Cessation
- 1983-01-25 ES ES519246A patent/ES519246A0/es active Granted
- 1983-01-25 SE SE8300370A patent/SE462653B/sv not_active IP Right Cessation
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
- 1983-01-25 DK DK028683A patent/DK160869C/da not_active IP Right Cessation
- 1983-01-25 PT PT76138A patent/PT76138A/pt not_active IP Right Cessation
- 1983-01-25 FI FI830247A patent/FI85013C/fi not_active IP Right Cessation
-
1984
- 1984-04-11 ES ES531508A patent/ES8505943A1/es not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT1201087B (it) | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche | |
IL69198A (en) | N-(bicyclic heterocyclyl)-4-piperidinamines,their preparation and pharmaceutical compositions containing them | |
IL70365A0 (en) | Substituted tetrapeptides,their manufacture and pharmaceutical compositions containing them | |
IT1168734B (it) | Cefem composti ad attivita' farmaceutica e procedimenti per la loro preparazione | |
IT1203647B (it) | Uree e tiouree sostituite aventi attivita' antiaterosclerotica,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono | |
IT1167123B (it) | Benzoazacicloalchilspiro-imidazolidine,procedimento per prepararle e composizioni farmaceutiche che le contengono | |
IT1200163B (it) | 8alfa-acilamminoergoline, loro preparazione e composizioni farmaceutiche che le contengono | |
IL69777A (en) | N-(1-(4-amino-6,7-dialkoxy-2-quinazolinyl)-4-piperidyl)-oxozolidine-2,4-diones,their preparation and pharmaceutical compositions containing them | |
IT8219486A0 (it) | Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche. | |
IT1177981B (it) | Amminociclopentani, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione | |
IT8320468A0 (it) | Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono. | |
IT1172268B (it) | Piperidinoguanidine sostituite,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono | |
IT1170361B (it) | Cianoguanidine, procedimento per ottenerle e composizioni farmaceutiche che le contengono | |
IT1167746B (it) | Nitroimidazoli ad attivita' tricomonacida, procedimento per la loro preparazione e relative composizioni farmaceutiche | |
IT8747852A0 (it) | Benzammidi sostituite, procedimento per la loro preparazione e composizioni farmaceutiche che le contengono | |
IT8219213A0 (it) | Composto ad attivita' mucoregolatri ce e antitosse,procedimento per lasua preparazione e relative composizioni farmaceutiche | |
IT1148621B (it) | 3-alchil,4-carbossi butirrilcarnitine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono | |
IT1198378B (it) | Composti idrossiminici e alcossiminici ad attivita' calcioanatagonista,procedimento per la loro preparazione e relative composizioni farmaceutiche | |
IT1217192B (it) | Tioeteri chinolinici,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono | |
IT1218324B (it) | Composti ad attivita' calcio-antagonista,metodo per la loro preparazione e composizioni farmaceutiche | |
IT1197654B (it) | Fenilossialchil-piperidine,procedimenti per prepararle e composizioni farmaceutiche che le contengono | |
IT8219215A0 (it) | Composto ad attivita' analgesica, antiinfiammatoria e mucoregolatrice procedimento per la sua preparazione e relative composizioni farmaceutiche | |
IT8219901A0 (it) | Composto ad attivita' antivirale, procedimento per la sua preparazione e relative composizioni farmaceutiche. | |
IT8321044A0 (it) | Per la loro preparazione e relative composti idrossiminici e composizioni farmaceutiche. alcossiminici ad attivita'calcio-antagonista, procedimento | |
IT8319981A0 (it) | Composti ad attivita' antivirale, procedimento per la loro preparazione e composizioni farmaceutiche cheli contengono. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950131 |