GB2113684B - Antiatherosclerotic substituted ureas and thioureas - Google Patents

Antiatherosclerotic substituted ureas and thioureas

Info

Publication number
GB2113684B
GB2113684B GB08301863A GB8301863A GB2113684B GB 2113684 B GB2113684 B GB 2113684B GB 08301863 A GB08301863 A GB 08301863A GB 8301863 A GB8301863 A GB 8301863A GB 2113684 B GB2113684 B GB 2113684B
Authority
GB
United Kingdom
Prior art keywords
antiatherosclerotic
thioureas
substituted ureas
ureas
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08301863A
Other languages
English (en)
Other versions
GB2113684A (en
GB8301863D0 (en
Inventor
Vern Gordon Devries
Elwood Eugene Largis
Ransom Brown Conrow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB8301863D0 publication Critical patent/GB8301863D0/en
Publication of GB2113684A publication Critical patent/GB2113684A/en
Application granted granted Critical
Publication of GB2113684B publication Critical patent/GB2113684B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
GB08301863A 1982-01-26 1983-01-24 Antiatherosclerotic substituted ureas and thioureas Expired GB2113684B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (3)

Publication Number Publication Date
GB8301863D0 GB8301863D0 (en) 1983-02-23
GB2113684A GB2113684A (en) 1983-08-10
GB2113684B true GB2113684B (en) 1985-12-18

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08301863A Expired GB2113684B (en) 1982-01-26 1983-01-24 Antiatherosclerotic substituted ureas and thioureas

Country Status (20)

Country Link
KR (1) KR890001808B1 (fr)
AT (1) AT391313B (fr)
AU (1) AU562699B2 (fr)
CH (1) CH654571A5 (fr)
DE (1) DE3247581A1 (fr)
DK (1) DK160869C (fr)
ES (2) ES8406422A1 (fr)
FI (1) FI85013C (fr)
FR (1) FR2521134B1 (fr)
GB (1) GB2113684B (fr)
GR (1) GR77186B (fr)
HU (1) HU200746B (fr)
IE (1) IE54683B1 (fr)
IL (1) IL67417A (fr)
IT (1) IT1203647B (fr)
NL (1) NL8300269A (fr)
NO (1) NO158417C (fr)
PL (1) PL143836B1 (fr)
PT (1) PT76138A (fr)
SE (1) SE462653B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
ATE98223T1 (de) * 1988-03-30 1993-12-15 Warner Lambert Co N-(((2,6-disubstituierte)phenyl>n'- arylalkyl> harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel.
WO1991011994A1 (fr) * 1990-02-14 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Inhibiteur de la formation de lipoproteines denaturees de faible densite
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
JP3612328B2 (ja) * 1992-07-20 2005-01-19 エーザイ株式会社 ベンゼン誘導体
JP2003524574A (ja) * 1997-08-05 2003-08-19 ノボ ノルディスク アクティーゼルスカブ ２，５−及び３，５−二置換アニリン誘導体、その調製及び使用
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
CA2284864A1 (fr) * 1998-01-21 1999-07-29 Zymogenetics, Inc. Dialkylurees utilisees en tant que substances imitant la calcitonine
WO2009009122A2 (fr) * 2007-07-10 2009-01-15 Amgen Inc. Dérivés de l'urée et de diamines associées, leurs procédés de fabrication, et leurs utilisations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL212631A (fr) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
DE3247581A1 (de) 1983-08-04
NO830238L (no) 1983-07-27
SE8300370L (sv) 1983-07-27
PL143836B1 (en) 1988-03-31
ES519246A0 (es) 1984-08-01
FR2521134B1 (fr) 1987-01-09
FI85013C (fi) 1992-02-25
KR890001808B1 (ko) 1989-05-23
NL8300269A (nl) 1983-08-16
HU200746B (en) 1990-08-28
PL240284A1 (en) 1985-01-02
PT76138A (en) 1983-02-01
IL67417A (en) 1989-10-31
SE8300370D0 (sv) 1983-01-25
ES8505943A1 (es) 1985-07-01
DK160869B (da) 1991-04-29
AT391313B (de) 1990-09-25
DK160869C (da) 1991-10-14
IT1203647B (it) 1989-02-15
NO158417C (no) 1988-09-07
IE830146L (en) 1983-07-26
NO158417B (no) 1988-05-30
ATA23983A (de) 1990-03-15
DK28683D0 (da) 1983-01-25
ES531508A0 (es) 1985-07-01
GB2113684A (en) 1983-08-10
GR77186B (fr) 1984-09-11
FI85013B (fi) 1991-11-15
KR840002773A (ko) 1984-07-16
CH654571A5 (de) 1986-02-28
ES8406422A1 (es) 1984-08-01
GB8301863D0 (en) 1983-02-23
AU562699B2 (en) 1987-06-18
FR2521134A1 (fr) 1983-08-12
FI830247L (fi) 1983-07-27
AU1068183A (en) 1983-08-04
SE462653B (sv) 1990-08-06
IT8347605A0 (it) 1983-01-25
FI830247A0 (fi) 1983-01-25
DK28683A (da) 1983-07-27
IE54683B1 (en) 1990-01-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19960124