CH634819A5 - Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkyl-amino methyl]-benzhydrols. - Google Patents
Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkyl-amino methyl]-benzhydrols. Download PDFInfo
- Publication number
- CH634819A5 CH634819A5 CH830178A CH830178A CH634819A5 CH 634819 A5 CH634819 A5 CH 634819A5 CH 830178 A CH830178 A CH 830178A CH 830178 A CH830178 A CH 830178A CH 634819 A5 CH634819 A5 CH 634819A5
- Authority
- CH
- Switzerland
- Prior art keywords
- reaction
- compound
- formula
- methyl
- sodium borohydride
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 25
- 238000002360 preparation method Methods 0.000 title claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- 239000012279 sodium borohydride Substances 0.000 claims description 17
- 229910000033 sodium borohydride Inorganic materials 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 12
- 239000011541 reaction mixture Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 239000000460 chlorine Chemical group 0.000 claims description 6
- 239000012442 inert solvent Substances 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 230000002140 halogenating effect Effects 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 description 28
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 14
- 238000010992 reflux Methods 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000006722 reduction reaction Methods 0.000 description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 239000002002 slurry Substances 0.000 description 7
- 238000004809 thin layer chromatography Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000002904 solvent Substances 0.000 description 6
- 239000010410 layer Substances 0.000 description 5
- -1 lithium aluminum hydride Chemical compound 0.000 description 5
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- BFVYSPGKIADILF-UHFFFAOYSA-N 2-benzoyl-n-(2-chloroethyl)-n-methylbenzamide Chemical compound ClCCN(C)C(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 BFVYSPGKIADILF-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 4
- 239000012280 lithium aluminium hydride Substances 0.000 description 4
- GKJLBCCOYHLILR-UHFFFAOYSA-N 2-phenyl-3h-4,1-benzoxazocine Chemical compound C1OC=CC2=CC=CC=C2N=C1C1=CC=CC=C1 GKJLBCCOYHLILR-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003638 chemical reducing agent Substances 0.000 description 3
- QILSFLSDHQAZET-UHFFFAOYSA-N diphenylmethanol Chemical compound C=1C=CC=CC=1C(O)C1=CC=CC=C1 QILSFLSDHQAZET-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 2
- YQOHPRYMRZWLTA-UHFFFAOYSA-N 2-benzoyl-n-(2-hydroxyethyl)-n-methylbenzamide Chemical compound OCCN(C)C(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 YQOHPRYMRZWLTA-UHFFFAOYSA-N 0.000 description 2
- FGTYTUFKXYPTML-UHFFFAOYSA-N 2-benzoylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 FGTYTUFKXYPTML-UHFFFAOYSA-N 0.000 description 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- RJGUJPSNJFGFLK-UHFFFAOYSA-N 1,1-dichloroethane;hydrochloride Chemical compound Cl.CC(Cl)Cl RJGUJPSNJFGFLK-UHFFFAOYSA-N 0.000 description 1
- NHTAQNXZFMZXBU-UHFFFAOYSA-N 2-[[2-[hydroxy(phenyl)methyl]phenyl]methyl-methylamino]ethanol Chemical compound OCCN(C)CC1=CC=CC=C1C(O)C1=CC=CC=C1 NHTAQNXZFMZXBU-UHFFFAOYSA-N 0.000 description 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N N-alpha-Methylhistamine Chemical compound CNCCC1=CN=CN1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000010640 amide synthesis reaction Methods 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229910000085 borane Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000010667 large scale reaction Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB33006/77A GB1586578A (en) | 1977-08-05 | 1977-08-05 | Process for the preparation of 2-(n-(2-hydroxyyethyl)-n-lower alkylaminomethyl) benzhydrols |
Publications (1)
Publication Number | Publication Date |
---|---|
CH634819A5 true CH634819A5 (en) | 1983-02-28 |
Family
ID=10347271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH830178A CH634819A5 (en) | 1977-08-05 | 1978-08-04 | Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkyl-amino methyl]-benzhydrols. |
Country Status (24)
Country | Link |
---|---|
JP (1) | JPS5839145B2 (es) |
AT (1) | AT358010B (es) |
AU (1) | AU524563B2 (es) |
BE (1) | BE869550A (es) |
CA (1) | CA1117551A (es) |
CH (1) | CH634819A5 (es) |
CS (1) | CS202017B2 (es) |
DE (1) | DE2834312A1 (es) |
DK (1) | DK149120C (es) |
ES (1) | ES472301A1 (es) |
FI (1) | FI67536C (es) |
FR (1) | FR2399405A1 (es) |
GB (1) | GB1586578A (es) |
HU (1) | HU175657B (es) |
IL (1) | IL55286A (es) |
IT (1) | IT7826533A0 (es) |
MX (1) | MX5783E (es) |
NL (1) | NL7808113A (es) |
NO (1) | NO146023C (es) |
NZ (1) | NZ188068A (es) |
PL (1) | PL111230B1 (es) |
SE (1) | SE441826B (es) |
SU (1) | SU984403A3 (es) |
ZA (1) | ZA784437B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI800076A (fi) * | 1980-01-11 | 1981-07-12 | Farmos Oy | Foerfarande foer framstaellning av benzhydrolderivat |
DE3206660A1 (de) * | 1982-02-25 | 1983-09-01 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von o-acylamidomethylbenzyl-halogeniden |
EP1572672B1 (en) * | 2002-12-20 | 2008-08-13 | Sosei R&D Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3830803A (en) * | 1965-05-10 | 1974-08-20 | Riker Laboratories Inc | 5-loweralkyl-1-phenyl-1,3,4,6-tetrahydro-5h-benz(f)-2,5-oxazocines and 4-ones |
GB1391862A (en) * | 1973-04-04 | 1975-04-23 | Yeda Res & Dev | Benzodiazepines |
-
1977
- 1977-08-05 GB GB33006/77A patent/GB1586578A/en not_active Expired
-
1978
- 1978-08-02 SE SE7808337A patent/SE441826B/sv not_active IP Right Cessation
- 1978-08-02 DK DK342278A patent/DK149120C/da not_active IP Right Cessation
- 1978-08-02 NO NO782643A patent/NO146023C/no unknown
- 1978-08-02 ES ES472301A patent/ES472301A1/es not_active Expired
- 1978-08-02 NL NL787808113A patent/NL7808113A/xx active Search and Examination
- 1978-08-03 CA CA000308679A patent/CA1117551A/en not_active Expired
- 1978-08-04 JP JP53095155A patent/JPS5839145B2/ja not_active Expired
- 1978-08-04 PL PL1978208868A patent/PL111230B1/pl unknown
- 1978-08-04 DE DE19782834312 patent/DE2834312A1/de active Granted
- 1978-08-04 IL IL55286A patent/IL55286A/xx active IP Right Grant
- 1978-08-04 FI FI782404A patent/FI67536C/fi not_active IP Right Cessation
- 1978-08-04 AU AU38633/78A patent/AU524563B2/en not_active Expired
- 1978-08-04 BE BE189728A patent/BE869550A/xx not_active IP Right Cessation
- 1978-08-04 HU HU78RI681A patent/HU175657B/hu unknown
- 1978-08-04 CH CH830178A patent/CH634819A5/de not_active IP Right Cessation
- 1978-08-04 MX MX787290U patent/MX5783E/es unknown
- 1978-08-04 FR FR7823129A patent/FR2399405A1/fr active Granted
- 1978-08-04 SU SU782645753A patent/SU984403A3/ru active
- 1978-08-04 IT IT7826533A patent/IT7826533A0/it unknown
- 1978-08-04 CS CS785140A patent/CS202017B2/cs unknown
- 1978-08-04 NZ NZ188068A patent/NZ188068A/xx unknown
- 1978-08-04 ZA ZA00784437A patent/ZA784437B/xx unknown
- 1978-08-04 AT AT569678A patent/AT358010B/de not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |