CH631625A5 - Process for the production of a stable insulin preparation having a lasting action - Google Patents

Process for the production of a stable insulin preparation having a lasting action Download PDF

Info

Publication number
CH631625A5
CH631625A5 CH47076A CH47076A CH631625A5 CH 631625 A5 CH631625 A5 CH 631625A5 CH 47076 A CH47076 A CH 47076A CH 47076 A CH47076 A CH 47076A CH 631625 A5 CH631625 A5 CH 631625A5
Authority
CH
Switzerland
Prior art keywords
insulin
protein
solution
preparation
dissociating
Prior art date
Application number
CH47076A
Other languages
German (de)
English (en)
Inventor
Bruno Andre Hansen
Finn Hede Andresen
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of CH631625A5 publication Critical patent/CH631625A5/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • C07K14/625Extraction from natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CH47076A 1975-01-15 1976-01-15 Process for the production of a stable insulin preparation having a lasting action CH631625A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.

Publications (1)

Publication Number Publication Date
CH631625A5 true CH631625A5 (en) 1982-08-31

Family

ID=8089535

Family Applications (1)

Application Number Title Priority Date Filing Date
CH47076A CH631625A5 (en) 1975-01-15 1976-01-15 Process for the production of a stable insulin preparation having a lasting action

Country Status (36)

Country Link
JP (1) JPS5946939B2 (pt)
AR (1) AR213088A1 (pt)
AT (1) AT362492B (pt)
BE (1) BE837600A (pt)
BR (1) BR7600206A (pt)
CA (1) CA1094549A (pt)
CH (1) CH631625A5 (pt)
CS (1) CS208147B2 (pt)
DD (1) DD124379A5 (pt)
DE (1) DE2600971C2 (pt)
DK (1) DK140801B (pt)
EG (1) EG11988A (pt)
ES (1) ES444558A1 (pt)
FI (1) FI66751C (pt)
FR (1) FR2297634A1 (pt)
GB (1) GB1524431A (pt)
GR (1) GR58608B (pt)
HU (1) HU175142B (pt)
IE (1) IE42395B1 (pt)
IL (1) IL48845A (pt)
IN (1) IN143279B (pt)
IT (1) IT1054211B (pt)
KE (1) KE2919A (pt)
LU (1) LU74175A1 (pt)
MX (1) MX4052E (pt)
MY (1) MY7900169A (pt)
NL (1) NL166464C (pt)
NO (1) NO146698C (pt)
NZ (1) NZ179733A (pt)
OA (1) OA05209A (pt)
PL (1) PL99927B1 (pt)
PT (1) PT64696B (pt)
RO (1) RO71576A (pt)
SE (1) SE437219B (pt)
YU (1) YU8376A (pt)
ZA (1) ZA7658B (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278474A1 (en) * 1987-02-10 1988-08-17 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
EP0278473A1 (en) * 1987-02-10 1988-08-17 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK374579A (da) * 1979-09-07 1981-03-08 Nordisk Insulinlab Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
JP5670421B2 (ja) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング コンポーネント表面のコーティング方法
EP2432531B1 (de) 2009-05-18 2019-03-06 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
CA2781792C (en) 2009-11-25 2019-04-02 Boehringer Ingelheim International Gmbh Nebulizer
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
PL2835146T3 (pl) 2013-08-09 2021-04-06 Boehringer Ingelheim International Gmbh Nebulizator
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
ES2913297T3 (es) 2014-05-07 2022-06-01 Boehringer Ingelheim Int Nebulizador
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278474A1 (en) * 1987-02-10 1988-08-17 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
EP0278473A1 (en) * 1987-02-10 1988-08-17 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins

Also Published As

Publication number Publication date
PT64696A (fr) 1976-02-01
ATA21376A (de) 1980-10-15
FI760058A (pt) 1976-07-16
DK8375A (pt) 1976-07-16
NO146698B (no) 1982-08-16
GB1524431A (en) 1978-09-13
DD124379A5 (pt) 1977-02-16
JPS5946939B2 (ja) 1984-11-15
SE437219B (sv) 1985-02-18
FI66751C (fi) 1984-12-10
IE42395B1 (en) 1980-07-30
IT1054211B (it) 1981-11-10
AR213088A1 (es) 1978-12-15
FR2297634B1 (pt) 1979-03-30
IE42395L (en) 1976-07-15
IL48845A (en) 1981-06-29
NL166464C (nl) 1981-08-17
NL166464B (nl) 1981-03-16
BE837600A (fr) 1976-07-15
DE2600971C2 (de) 1985-12-12
NL7600338A (nl) 1976-07-19
OA05209A (fr) 1981-02-28
IN143279B (pt) 1977-10-29
PT64696B (fr) 1977-08-10
MY7900169A (en) 1979-12-31
DE2600971A1 (de) 1976-07-22
ZA7658B (en) 1976-12-29
GR58608B (en) 1977-11-10
HU175142B (hu) 1980-05-28
LU74175A1 (pt) 1977-03-18
YU8376A (en) 1982-06-30
PL99927B1 (pl) 1978-08-31
MX4052E (es) 1981-11-24
NO146698C (no) 1982-11-24
AU1030776A (en) 1977-07-21
KE2919A (en) 1979-03-30
AT362492B (de) 1981-05-25
DK140801B (da) 1979-11-19
DK140801C (pt) 1980-04-21
RO71576A (ro) 1980-12-30
ES444558A1 (es) 1977-05-16
SE7600284L (sv) 1976-07-16
JPS51125299A (en) 1976-11-01
BR7600206A (pt) 1976-08-31
FI66751B (fi) 1984-08-31
NO760118L (pt) 1976-07-16
EG11988A (en) 1978-06-30
CA1094549A (en) 1981-01-27
NZ179733A (en) 1978-04-28
CS208147B2 (en) 1981-08-31
FR2297634A1 (fr) 1976-08-13
IL48845A0 (en) 1976-03-31

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PL Patent ceased