FI66751C - Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan - Google Patents

Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan Download PDF

Info

Publication number
FI66751C
FI66751C FI760058A FI760058A FI66751C FI 66751 C FI66751 C FI 66751C FI 760058 A FI760058 A FI 760058A FI 760058 A FI760058 A FI 760058A FI 66751 C FI66751 C FI 66751C
Authority
FI
Finland
Prior art keywords
insulin
reaction
solution
urea
protamine
Prior art date
Application number
FI760058A
Other languages
English (en)
Finnish (fi)
Other versions
FI66751B (fi
FI760058A (pt
Inventor
Bruno Andre Hansen
Finn Hede Andresen
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of FI760058A publication Critical patent/FI760058A/fi
Publication of FI66751B publication Critical patent/FI66751B/fi
Application granted granted Critical
Publication of FI66751C publication Critical patent/FI66751C/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • C07K14/625Extraction from natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI760058A 1975-01-15 1976-01-12 Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan FI66751C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
DK8375 1975-01-15

Publications (3)

Publication Number Publication Date
FI760058A FI760058A (pt) 1976-07-16
FI66751B FI66751B (fi) 1984-08-31
FI66751C true FI66751C (fi) 1984-12-10

Family

ID=8089535

Family Applications (1)

Application Number Title Priority Date Filing Date
FI760058A FI66751C (fi) 1975-01-15 1976-01-12 Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan

Country Status (36)

Country Link
JP (1) JPS5946939B2 (pt)
AR (1) AR213088A1 (pt)
AT (1) AT362492B (pt)
BE (1) BE837600A (pt)
BR (1) BR7600206A (pt)
CA (1) CA1094549A (pt)
CH (1) CH631625A5 (pt)
CS (1) CS208147B2 (pt)
DD (1) DD124379A5 (pt)
DE (1) DE2600971C2 (pt)
DK (1) DK140801B (pt)
EG (1) EG11988A (pt)
ES (1) ES444558A1 (pt)
FI (1) FI66751C (pt)
FR (1) FR2297634A1 (pt)
GB (1) GB1524431A (pt)
GR (1) GR58608B (pt)
HU (1) HU175142B (pt)
IE (1) IE42395B1 (pt)
IL (1) IL48845A (pt)
IN (1) IN143279B (pt)
IT (1) IT1054211B (pt)
KE (1) KE2919A (pt)
LU (1) LU74175A1 (pt)
MX (1) MX4052E (pt)
MY (1) MY7900169A (pt)
NL (1) NL166464C (pt)
NO (1) NO146698C (pt)
NZ (1) NZ179733A (pt)
OA (1) OA05209A (pt)
PL (1) PL99927B1 (pt)
PT (1) PT64696B (pt)
RO (1) RO71576A (pt)
SE (1) SE437219B (pt)
YU (1) YU8376A (pt)
ZA (1) ZA7658B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK374579A (da) * 1979-09-07 1981-03-08 Nordisk Insulinlab Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
JP5670421B2 (ja) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング コンポーネント表面のコーティング方法
EP2432531B1 (de) 2009-05-18 2019-03-06 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5715640B2 (ja) 2009-11-25 2015-05-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
PL3139984T3 (pl) 2014-05-07 2021-11-08 Boehringer Ingelheim International Gmbh Nebulizator
CN106232166B (zh) 2014-05-07 2020-04-14 勃林格殷格翰国际有限公司 喷雾器
CN106255554B (zh) 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product

Also Published As

Publication number Publication date
RO71576A (ro) 1980-12-30
FI66751B (fi) 1984-08-31
IL48845A0 (en) 1976-03-31
MX4052E (es) 1981-11-24
LU74175A1 (pt) 1977-03-18
DK140801B (da) 1979-11-19
NO760118L (pt) 1976-07-16
YU8376A (en) 1982-06-30
AT362492B (de) 1981-05-25
DK8375A (pt) 1976-07-16
JPS5946939B2 (ja) 1984-11-15
AU1030776A (en) 1977-07-21
SE7600284L (sv) 1976-07-16
PT64696B (fr) 1977-08-10
NO146698C (no) 1982-11-24
IE42395L (en) 1976-07-15
NO146698B (no) 1982-08-16
FR2297634B1 (pt) 1979-03-30
PL99927B1 (pl) 1978-08-31
ZA7658B (en) 1976-12-29
DK140801C (pt) 1980-04-21
NL166464C (nl) 1981-08-17
JPS51125299A (en) 1976-11-01
ATA21376A (de) 1980-10-15
NZ179733A (en) 1978-04-28
IT1054211B (it) 1981-11-10
PT64696A (fr) 1976-02-01
OA05209A (fr) 1981-02-28
KE2919A (en) 1979-03-30
IL48845A (en) 1981-06-29
NL7600338A (nl) 1976-07-19
MY7900169A (en) 1979-12-31
IN143279B (pt) 1977-10-29
IE42395B1 (en) 1980-07-30
GR58608B (en) 1977-11-10
DD124379A5 (pt) 1977-02-16
FI760058A (pt) 1976-07-16
BE837600A (fr) 1976-07-15
CH631625A5 (en) 1982-08-31
ES444558A1 (es) 1977-05-16
GB1524431A (en) 1978-09-13
DE2600971A1 (de) 1976-07-22
AR213088A1 (es) 1978-12-15
HU175142B (hu) 1980-05-28
FR2297634A1 (fr) 1976-08-13
SE437219B (sv) 1985-02-18
DE2600971C2 (de) 1985-12-12
NL166464B (nl) 1981-03-16
CS208147B2 (en) 1981-08-31
EG11988A (en) 1978-06-30
BR7600206A (pt) 1976-08-31
CA1094549A (en) 1981-01-27

Similar Documents

Publication Publication Date Title
FI66751C (fi) Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan
US4183849A (en) Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
Brange Galenics of insulin: the physico-chemical and pharmaceutical aspects of insulin and insulin preparations
Bromer et al. Preparation and properties of fluoresceinthiocarbamyl insulins
US5631347A (en) Reducing gelation of a fatty acid-acylated protein
EP0194864B1 (en) Novel peptides
Erlanson et al. Purification and characterization of two proteins with co-lipase activity from porcine pancreas
CA1172978A (en) .alpha.-AMYLASE INACTIVATOR, A PROCESS FOR ITS PREPARATION, AN AGENT BASED ON THIS INACTIVATOR AND ITS USE
FI77876B (fi) Foerfarande foer framstaellning av humaninsulin eller en treoninb30-ester av humaninsulin eller ett salt eller komplex daerav.
EP0216833B1 (en) Novel insulin derivatives and pharmaceutical preparations containing these derivatives
US3907676A (en) Process for purifying insulin
IE50892B1 (en) Process for preparing insulin esters
Svendsen et al. Isolation and characterization of the folate-binding protein from cow's milk
Edmundson et al. Isolation and characterization of concanavalin A polypeptide chains
Hjorth et al. Purification and identification of high molecular weight products formed during storage of neutral formulation of human insulin
EP0032655B2 (en) A process in purification and concentration of the factor viii-complex
Free et al. Separation and properties of multiple components of bovine growth hormone
CA1113412A (en) Proteinic active substances
JP3470135B2 (ja) 成長ホルモンの結晶体を製造する方法およびそれにより得られる結晶体
JP2566919B2 (ja) α−インタ−フエロンの製造方法
KR20200038502A (ko) 신규한 아실화 인슐린 유사체 및 이의 용도
EP0146842B1 (en) Novel calcitonin and collection thereof
Tamura-Takahashi et al. Purification and properties of four biologically active components of whale luteinizing hormone
KR100229420B1 (ko) 대장균에서 발현된 닭 성장 호르몬의 정제 방법
Covelli et al. Carboxymethylation of the histidyl residues of insulin

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: NORDISK INSULINLABORATORIUM