DK140801B - Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat. - Google Patents

Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.

Info

Publication number
DK140801B
DK140801B DK8375AA DK8375A DK140801B DK 140801 B DK140801 B DK 140801B DK 8375A A DK8375A A DK 8375AA DK 8375 A DK8375 A DK 8375A DK 140801 B DK140801 B DK 140801B
Authority
DK
Denmark
Prior art keywords
preparation
acting insulin
stable long
insulin preparation
stable
Prior art date
Application number
DK8375AA
Other languages
Danish (da)
English (en)
Other versions
DK8375A (pt
DK140801C (pt
Inventor
Bruno Andre Hansen
Finn Hede Andresen
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Priority to DK8375AA priority Critical patent/DK140801B/da
Priority to ZA00760058A priority patent/ZA7658B/xx
Priority to GR49734A priority patent/GR58608B/el
Priority to IN41/CAL/76A priority patent/IN143279B/en
Priority to NZ179733A priority patent/NZ179733A/xx
Priority to CA243,587A priority patent/CA1094549A/en
Priority to FI760058A priority patent/FI66751C/fi
Priority to LU74175A priority patent/LU74175A1/xx
Priority to DE2600971A priority patent/DE2600971C2/de
Priority to IT19221/76A priority patent/IT1054211B/it
Priority to SE7600284A priority patent/SE437219B/xx
Priority to IE62/76A priority patent/IE42395B1/en
Priority to PT64696A priority patent/PT64696B/pt
Priority to GB1309/76A priority patent/GB1524431A/en
Priority to RO7684491A priority patent/RO71576A/ro
Priority to FR7600854A priority patent/FR2297634A1/fr
Priority to PL1976186526A priority patent/PL99927B1/pl
Priority to AT21376A priority patent/AT362492B/de
Priority to NO760118A priority patent/NO146698C/no
Priority to OA55703A priority patent/OA05209A/xx
Priority to BR7600206A priority patent/BR7600206A/pt
Priority to NL7600338.A priority patent/NL166464C/xx
Priority to DD190805A priority patent/DD124379A5/xx
Priority to YU00083/76A priority patent/YU8376A/xx
Priority to MX764822U priority patent/MX4052E/es
Priority to ES444558A priority patent/ES444558A1/es
Priority to HU76NO198A priority patent/HU175142B/hu
Priority to CH47076A priority patent/CH631625A5/de
Priority to CS76270A priority patent/CS208147B2/cs
Priority to BE163542A priority patent/BE837600A/xx
Priority to AU10307/76A priority patent/AU492004B2/en
Priority to IL48845A priority patent/IL48845A/xx
Priority to JP51003293A priority patent/JPS5946939B2/ja
Priority to EG16/76A priority patent/EG11988A/xx
Publication of DK8375A publication Critical patent/DK8375A/da
Priority to US05/858,916 priority patent/US4183849A/en
Priority to AR261924A priority patent/AR213088A1/es
Priority to KE2919A priority patent/KE2919A/xx
Publication of DK140801B publication Critical patent/DK140801B/da
Priority to MY169/79A priority patent/MY7900169A/xx
Application granted granted Critical
Publication of DK140801C publication Critical patent/DK140801C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK8375AA 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat. DK140801B (da)

Priority Applications (38)

Application Number Priority Date Filing Date Title
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
ZA00760058A ZA7658B (en) 1975-01-15 1976-01-06 A therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted efect
IN41/CAL/76A IN143279B (pt) 1975-01-15 1976-01-07
GR49734A GR58608B (en) 1975-01-15 1976-01-07 Process for the production of a stable insulin preparation with protracted effect
NZ179733A NZ179733A (en) 1975-01-15 1976-01-12 Stable insulin preparation
CA243,587A CA1094549A (en) 1975-01-15 1976-01-12 Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
FI760058A FI66751C (fi) 1975-01-15 1976-01-12 Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan
DE2600971A DE2600971C2 (de) 1975-01-15 1976-01-13 Verfahren zur Herstellung von Rinder-Insulin-Komplexen mit Dauerwirkung und diese Komplexe enthaltende Arzneimittel
IT19221/76A IT1054211B (it) 1975-01-15 1976-01-13 Preparazione d insulina e proce dimento per produrre una prepa razione stabile d insulina con effetto prolungato
SE7600284A SE437219B (sv) 1975-01-15 1976-01-13 Forfarande for framstellning av ett stabilt insulinpreparat med protraherad verkan
IE62/76A IE42395B1 (en) 1975-01-15 1976-01-13 Production of long acting insulin preparations
LU74175A LU74175A1 (pt) 1975-01-15 1976-01-13
OA55703A OA05209A (fr) 1975-01-15 1976-01-14 Procédé de production d'une préparation stable d'insuline.
RO7684491A RO71576A (ro) 1975-01-15 1976-01-14 Procedeu de obtinere a unui preparat stabil de insulina cu efect prelungit si antigenicitate scazuta
FR7600854A FR2297634A1 (fr) 1975-01-15 1976-01-14 Procede de production d'une preparation therapeutique stable d'insuline et produit obtenu
PL1976186526A PL99927B1 (pl) 1975-01-15 1976-01-14 Sposob wytwarzania trwalego preparatu insulinowego o przedluzonym dzialaniu
AT21376A AT362492B (de) 1975-01-15 1976-01-14 Verfahren zur herstellung eines stabilen insulinpraeparats mit dauerwirkung
NO760118A NO146698C (no) 1975-01-15 1976-01-14 Fremgangsmaate for fremstilling av et stabilt langtidsvirkende insulinprodukt.
PT64696A PT64696B (fr) 1975-01-15 1976-01-14 Procede de preparation de compositions d'insuline stables,avec action prolongee
BR7600206A BR7600206A (pt) 1975-01-15 1976-01-14 Processo para obter uma preparacao estavel de insulina de acao prolongada,bem como composicao e processo terapeuticos
NL7600338.A NL166464C (nl) 1975-01-15 1976-01-14 Werkwijze voor het bereiden van een stabiel insuline met langdurige werking en lage antigeenactiviteit.
DD190805A DD124379A5 (pt) 1975-01-15 1976-01-14
YU00083/76A YU8376A (en) 1975-01-15 1976-01-14 Process for producing a stable insulin preparation with retarded action
MX764822U MX4052E (es) 1975-01-15 1976-01-14 Procedimiento mejorado para la produccion de una preparacion de insulina estable con efecto prolongado
GB1309/76A GB1524431A (en) 1975-01-15 1976-01-14 Production of long acting insulin preparations
HU76NO198A HU175142B (hu) 1975-01-15 1976-01-15 Sposob poluchenija kompoziciju inzulina s dlinnojj aktivnost'ju i s malenkojj antigennojj aktivnost'ju
ES444558A ES444558A1 (es) 1975-01-15 1976-01-15 Procedimiento para la produccion de una preparacion estable de insulina.
CH47076A CH631625A5 (en) 1975-01-15 1976-01-15 Process for the production of a stable insulin preparation having a lasting action
CS76270A CS208147B2 (en) 1975-01-15 1976-01-15 Method of making the stabile low antigennous or the antigene of the plain insuline preparation of the protracted effect
BE163542A BE837600A (fr) 1975-01-15 1976-01-15 Composition d'insuline et son procede de preparation
AU10307/76A AU492004B2 (en) 1976-01-15 A therapeutic insulin preparation anda process forthe production ofa stable insulin preparation with protracted effect
IL48845A IL48845A (en) 1975-01-15 1976-01-15 Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
JP51003293A JPS5946939B2 (ja) 1975-01-15 1976-01-16 インシユリンの製造方法
EG16/76A EG11988A (en) 1975-01-15 1976-01-17 A process for producing a stable insulin preparation with protracted effect
US05/858,916 US4183849A (en) 1975-01-15 1977-12-08 Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
AR261924A AR213088A1 (es) 1975-01-15 1978-01-14 Procedimiento para la produccion de una preparacion de insulina estable con efecto prolongado
KE2919A KE2919A (en) 1975-01-15 1979-02-07 Production of long acting insulin preparations
MY169/79A MY7900169A (en) 1975-01-15 1979-12-30 Production of long acting insulin preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.

Publications (3)

Publication Number Publication Date
DK8375A DK8375A (pt) 1976-07-16
DK140801B true DK140801B (da) 1979-11-19
DK140801C DK140801C (pt) 1980-04-21

Family

ID=8089535

Family Applications (1)

Application Number Title Priority Date Filing Date
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.

Country Status (36)

Country Link
JP (1) JPS5946939B2 (pt)
AR (1) AR213088A1 (pt)
AT (1) AT362492B (pt)
BE (1) BE837600A (pt)
BR (1) BR7600206A (pt)
CA (1) CA1094549A (pt)
CH (1) CH631625A5 (pt)
CS (1) CS208147B2 (pt)
DD (1) DD124379A5 (pt)
DE (1) DE2600971C2 (pt)
DK (1) DK140801B (pt)
EG (1) EG11988A (pt)
ES (1) ES444558A1 (pt)
FI (1) FI66751C (pt)
FR (1) FR2297634A1 (pt)
GB (1) GB1524431A (pt)
GR (1) GR58608B (pt)
HU (1) HU175142B (pt)
IE (1) IE42395B1 (pt)
IL (1) IL48845A (pt)
IN (1) IN143279B (pt)
IT (1) IT1054211B (pt)
KE (1) KE2919A (pt)
LU (1) LU74175A1 (pt)
MX (1) MX4052E (pt)
MY (1) MY7900169A (pt)
NL (1) NL166464C (pt)
NO (1) NO146698C (pt)
NZ (1) NZ179733A (pt)
OA (1) OA05209A (pt)
PL (1) PL99927B1 (pt)
PT (1) PT64696B (pt)
RO (1) RO71576A (pt)
SE (1) SE437219B (pt)
YU (1) YU8376A (pt)
ZA (1) ZA7658B (pt)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK374579A (da) * 1979-09-07 1981-03-08 Nordisk Insulinlab Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer

Also Published As

Publication number Publication date
RO71576A (ro) 1980-12-30
FI66751B (fi) 1984-08-31
IL48845A0 (en) 1976-03-31
MX4052E (es) 1981-11-24
LU74175A1 (pt) 1977-03-18
NO760118L (pt) 1976-07-16
YU8376A (en) 1982-06-30
AT362492B (de) 1981-05-25
DK8375A (pt) 1976-07-16
JPS5946939B2 (ja) 1984-11-15
AU1030776A (en) 1977-07-21
SE7600284L (sv) 1976-07-16
PT64696B (fr) 1977-08-10
NO146698C (no) 1982-11-24
IE42395L (en) 1976-07-15
NO146698B (no) 1982-08-16
FR2297634B1 (pt) 1979-03-30
PL99927B1 (pl) 1978-08-31
ZA7658B (en) 1976-12-29
DK140801C (pt) 1980-04-21
NL166464C (nl) 1981-08-17
JPS51125299A (en) 1976-11-01
ATA21376A (de) 1980-10-15
NZ179733A (en) 1978-04-28
IT1054211B (it) 1981-11-10
PT64696A (fr) 1976-02-01
OA05209A (fr) 1981-02-28
KE2919A (en) 1979-03-30
IL48845A (en) 1981-06-29
NL7600338A (nl) 1976-07-19
MY7900169A (en) 1979-12-31
IN143279B (pt) 1977-10-29
IE42395B1 (en) 1980-07-30
GR58608B (en) 1977-11-10
DD124379A5 (pt) 1977-02-16
FI760058A (pt) 1976-07-16
BE837600A (fr) 1976-07-15
CH631625A5 (en) 1982-08-31
ES444558A1 (es) 1977-05-16
GB1524431A (en) 1978-09-13
DE2600971A1 (de) 1976-07-22
AR213088A1 (es) 1978-12-15
HU175142B (hu) 1980-05-28
FR2297634A1 (fr) 1976-08-13
FI66751C (fi) 1984-12-10
SE437219B (sv) 1985-02-18
DE2600971C2 (de) 1985-12-12
NL166464B (nl) 1981-03-16
CS208147B2 (en) 1981-08-31
EG11988A (en) 1978-06-30
BR7600206A (pt) 1976-08-31
CA1094549A (en) 1981-01-27

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