CH629783A5 - Process for the preparation of 14-hydroxymorphinan derivatives - Google Patents

Process for the preparation of 14-hydroxymorphinan derivatives Download PDF

Info

Publication number
CH629783A5
CH629783A5 CH358077A CH358077A CH629783A5 CH 629783 A5 CH629783 A5 CH 629783A5 CH 358077 A CH358077 A CH 358077A CH 358077 A CH358077 A CH 358077A CH 629783 A5 CH629783 A5 CH 629783A5
Authority
CH
Switzerland
Prior art keywords
formula
compound
acid
borane
process step
Prior art date
Application number
CH358077A
Other languages
German (de)
English (en)
Inventor
Ivo Monkovic
Carol Bachand
Henry Wong
Gary Lim
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,795 external-priority patent/US4058531A/en
Priority claimed from US05/769,808 external-priority patent/US4139534A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CH629783A5 publication Critical patent/CH629783A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CH358077A 1976-03-23 1977-03-22 Process for the preparation of 14-hydroxymorphinan derivatives CH629783A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/669,795 US4058531A (en) 1976-03-23 1976-03-23 Process for the preparation of 14-hydroxymorphinan derivatives
US05/769,808 US4139534A (en) 1977-02-17 1977-02-17 Process for the preparation of 14-hydroxymorphinan derivatives

Publications (1)

Publication Number Publication Date
CH629783A5 true CH629783A5 (en) 1982-05-14

Family

ID=27100195

Family Applications (1)

Application Number Title Priority Date Filing Date
CH358077A CH629783A5 (en) 1976-03-23 1977-03-22 Process for the preparation of 14-hydroxymorphinan derivatives

Country Status (8)

Country Link
JP (1) JPS52136176A (ja)
CA (1) CA1086723A (ja)
CH (1) CH629783A5 (ja)
DK (2) DK155322C (ja)
FI (1) FI61486C (ja)
LU (1) LU77000A1 (ja)
NL (2) NL189846C (ja)
SE (1) SE431749B (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0373510U (ja) * 1989-11-15 1991-07-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
CA919668A (en) * 1970-06-20 1973-01-23 Murakami Masuo Morphinan derivatives
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
DK597188D0 (da) 1988-10-27
FI61486C (fi) 1982-08-10
SE431749B (sv) 1984-02-27
SE7703236L (sv) 1977-09-24
DK123877A (da) 1977-09-24
NL189846C (nl) 1993-08-16
JPS52136176A (en) 1977-11-14
JPS6139938B2 (ja) 1986-09-06
FI61486B (fi) 1982-04-30
NL7703000A (nl) 1977-09-27
CA1086723A (en) 1980-09-30
NL189846B (nl) 1993-03-16
DK597188A (da) 1988-10-27
FI770865A (ja) 1977-09-24
NL960022I1 (nl) 1996-12-02
DK155322B (da) 1989-03-28
LU77000A1 (ja) 1977-10-03
DK155322C (da) 1989-09-11
DK160987C (da) 1991-11-11
DK160987B (da) 1991-05-13

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Legal Events

Date Code Title Description
PL Patent ceased