CA1086723A - Process for the preparation of 14-hydroxymorphinan derivatives - Google Patents

Process for the preparation of 14-hydroxymorphinan derivatives

Info

Publication number
CA1086723A
CA1086723A CA274,241A CA274241A CA1086723A CA 1086723 A CA1086723 A CA 1086723A CA 274241 A CA274241 A CA 274241A CA 1086723 A CA1086723 A CA 1086723A
Authority
CA
Canada
Prior art keywords
compound
boron
formula
borane
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA274,241A
Other languages
English (en)
French (fr)
Inventor
Ivo Monkovic
Henry Wong
Gary M.F. Lim
Carol Bachand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,795 external-priority patent/US4058531A/en
Priority claimed from US05/769,808 external-priority patent/US4139534A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to CA339,989A priority Critical patent/CA1091675A/en
Application granted granted Critical
Publication of CA1086723A publication Critical patent/CA1086723A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA274,241A 1976-03-23 1977-03-18 Process for the preparation of 14-hydroxymorphinan derivatives Expired CA1086723A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA339,989A CA1091675A (en) 1976-03-23 1979-11-16 2-cycloalkylmethyl-9,10-dihydroxy-1-(p- methoxybenzyl)perhydroisoquinoline compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US05/669,795 US4058531A (en) 1976-03-23 1976-03-23 Process for the preparation of 14-hydroxymorphinan derivatives
US669,795 1976-03-23
US05/769,808 US4139534A (en) 1977-02-17 1977-02-17 Process for the preparation of 14-hydroxymorphinan derivatives
US769,808 1977-02-17

Publications (1)

Publication Number Publication Date
CA1086723A true CA1086723A (en) 1980-09-30

Family

ID=27100195

Family Applications (1)

Application Number Title Priority Date Filing Date
CA274,241A Expired CA1086723A (en) 1976-03-23 1977-03-18 Process for the preparation of 14-hydroxymorphinan derivatives

Country Status (8)

Country Link
JP (1) JPS52136176A (ja)
CA (1) CA1086723A (ja)
CH (1) CH629783A5 (ja)
DK (2) DK155322C (ja)
FI (1) FI61486C (ja)
LU (1) LU77000A1 (ja)
NL (2) NL189846C (ja)
SE (1) SE431749B (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0373510U (ja) * 1989-11-15 1991-07-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
CA919668A (en) * 1970-06-20 1973-01-23 Murakami Masuo Morphinan derivatives
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
DK597188D0 (da) 1988-10-27
FI61486C (fi) 1982-08-10
SE431749B (sv) 1984-02-27
SE7703236L (sv) 1977-09-24
DK123877A (da) 1977-09-24
NL189846C (nl) 1993-08-16
JPS52136176A (en) 1977-11-14
JPS6139938B2 (ja) 1986-09-06
FI61486B (fi) 1982-04-30
NL7703000A (nl) 1977-09-27
CH629783A5 (en) 1982-05-14
NL189846B (nl) 1993-03-16
DK597188A (da) 1988-10-27
FI770865A (ja) 1977-09-24
NL960022I1 (nl) 1996-12-02
DK155322B (da) 1989-03-28
LU77000A1 (ja) 1977-10-03
DK155322C (da) 1989-09-11
DK160987C (da) 1991-11-11
DK160987B (da) 1991-05-13

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