JPS52136176A - Method of improving 144hydroxymorphinan derivatives - Google Patents

Method of improving 144hydroxymorphinan derivatives

Info

Publication number
JPS52136176A
JPS52136176A JP2871277A JP2871277A JPS52136176A JP S52136176 A JPS52136176 A JP S52136176A JP 2871277 A JP2871277 A JP 2871277A JP 2871277 A JP2871277 A JP 2871277A JP S52136176 A JPS52136176 A JP S52136176A
Authority
JP
Japan
Prior art keywords
derivatives
improving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2871277A
Other languages
English (en)
Other versions
JPS6139938B2 (ja
Inventor
Monkobitsuku Aibo
Baachiyando Kiyaroru
Uongu Henrii
Rimu Geerii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,795 external-priority patent/US4058531A/en
Priority claimed from US05/769,808 external-priority patent/US4139534A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS52136176A publication Critical patent/JPS52136176A/ja
Publication of JPS6139938B2 publication Critical patent/JPS6139938B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
JP2871277A 1976-03-23 1977-03-17 Method of improving 144hydroxymorphinan derivatives Granted JPS52136176A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/669,795 US4058531A (en) 1976-03-23 1976-03-23 Process for the preparation of 14-hydroxymorphinan derivatives
US05/769,808 US4139534A (en) 1977-02-17 1977-02-17 Process for the preparation of 14-hydroxymorphinan derivatives

Publications (2)

Publication Number Publication Date
JPS52136176A true JPS52136176A (en) 1977-11-14
JPS6139938B2 JPS6139938B2 (ja) 1986-09-06

Family

ID=27100195

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2871277A Granted JPS52136176A (en) 1976-03-23 1977-03-17 Method of improving 144hydroxymorphinan derivatives

Country Status (8)

Country Link
JP (1) JPS52136176A (ja)
CA (1) CA1086723A (ja)
CH (1) CH629783A5 (ja)
DK (2) DK155322C (ja)
FI (1) FI61486C (ja)
LU (1) LU77000A1 (ja)
NL (2) NL189846C (ja)
SE (1) SE431749B (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0373510U (ja) * 1989-11-15 1991-07-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
CA919668A (en) * 1970-06-20 1973-01-23 Murakami Masuo Morphinan derivatives
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
DK160987C (da) 1991-11-11
NL960022I1 (nl) 1996-12-02
CH629783A5 (en) 1982-05-14
DK160987B (da) 1991-05-13
DK155322B (da) 1989-03-28
SE431749B (sv) 1984-02-27
JPS6139938B2 (ja) 1986-09-06
DK597188D0 (da) 1988-10-27
NL7703000A (nl) 1977-09-27
SE7703236L (sv) 1977-09-24
DK155322C (da) 1989-09-11
DK597188A (da) 1988-10-27
FI61486B (fi) 1982-04-30
DK123877A (da) 1977-09-24
NL189846B (nl) 1993-03-16
FI770865A (ja) 1977-09-24
FI61486C (fi) 1982-08-10
CA1086723A (en) 1980-09-30
NL189846C (nl) 1993-08-16
LU77000A1 (ja) 1977-10-03

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