CH624114A5 - - Google Patents

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Publication number
CH624114A5
CH624114A5 CH699380A CH699380A CH624114A5 CH 624114 A5 CH624114 A5 CH 624114A5 CH 699380 A CH699380 A CH 699380A CH 699380 A CH699380 A CH 699380A CH 624114 A5 CH624114 A5 CH 624114A5
Authority
CH
Switzerland
Prior art keywords
formula
acid
noroxymorphone
tetrahydrofurfuryl
addition salts
Prior art date
Application number
CH699380A
Other languages
German (de)
English (en)
Inventor
Herbert Dr Merz
Gerhard Dr Walther
Adolf Dr Langbein
Klaus Dr Stockhaus
Helmut Dr Wick
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of CH624114A5 publication Critical patent/CH624114A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH699380A 1975-08-27 1980-09-18 CH624114A5 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752538075 DE2538075A1 (de) 1975-08-27 1975-08-27 N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CH624114A5 true CH624114A5 (ja) 1981-07-15

Family

ID=5954931

Family Applications (5)

Application Number Title Priority Date Filing Date
CH1079676A CH622521A5 (ja) 1975-08-27 1976-08-25
CH699480A CH624115A5 (ja) 1975-08-27 1980-09-18
CH699680A CH624117A5 (ja) 1975-08-27 1980-09-18
CH699380A CH624114A5 (ja) 1975-08-27 1980-09-18
CH699580A CH624116A5 (ja) 1975-08-27 1980-09-18

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CH1079676A CH622521A5 (ja) 1975-08-27 1976-08-25
CH699480A CH624115A5 (ja) 1975-08-27 1980-09-18
CH699680A CH624117A5 (ja) 1975-08-27 1980-09-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH699580A CH624116A5 (ja) 1975-08-27 1980-09-18

Country Status (33)

Country Link
US (1) US4100288A (ja)
JP (1) JPS5231100A (ja)
AT (1) AT350737B (ja)
AU (1) AU499926B2 (ja)
BE (1) BE845563A (ja)
BG (2) BG27545A3 (ja)
CA (1) CA1068266A (ja)
CH (5) CH622521A5 (ja)
CS (2) CS192599B2 (ja)
DD (1) DD127145A5 (ja)
DE (1) DE2538075A1 (ja)
DK (1) DK143278C (ja)
ES (5) ES450897A1 (ja)
FI (1) FI762430A (ja)
FR (1) FR2321888A1 (ja)
GB (1) GB1519719A (ja)
GR (1) GR61158B (ja)
HU (1) HU176929B (ja)
IE (1) IE44069B1 (ja)
IL (1) IL50355A (ja)
LU (1) LU75667A1 (ja)
MX (1) MX4133E (ja)
NL (1) NL7609485A (ja)
NO (1) NO145793C (ja)
NZ (1) NZ181864A (ja)
PH (1) PH13780A (ja)
PL (2) PL109091B1 (ja)
PT (1) PT65521B (ja)
RO (1) RO69457A (ja)
SE (1) SE7609495L (ja)
SU (2) SU612631A3 (ja)
YU (1) YU208176A (ja)
ZA (1) ZA765120B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE3220831A1 (de) * 1982-06-03 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
EP2010539B1 (en) * 2006-04-21 2017-06-14 Nektar Therapeutics Stereoselective reduction of a morphinone
WO2012005795A1 (en) 2010-07-08 2012-01-12 Alkermes, Inc. Process for the synthesis of substituted morphinans
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
AU2014268361B2 (en) 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
CN111836813A (zh) * 2018-02-23 2020-10-27 罗德科技公司 新型阿片样化合物及其用途
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446370A (de) 1964-03-05 1967-11-15 Hoffmann La Roche Verfahren zur Herstellung von Phenanthren-Derivaten
DE2238839A1 (de) * 1972-08-07 1974-02-14 Boehringer Sohn Ingelheim Neue morphinon-derivate, deren saeureadditionssalze, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
ES454086A1 (es) 1977-11-16
ZA765120B (en) 1978-05-30
NO145793B (no) 1982-02-22
RO69457A (ro) 1981-04-30
ATA553976A (de) 1978-11-15
SU612631A3 (ru) 1978-06-25
IL50355A (en) 1979-11-30
CH624117A5 (ja) 1981-07-15
PT65521A (de) 1976-09-01
NZ181864A (en) 1978-06-20
PH13780A (en) 1980-09-26
FI762430A (ja) 1977-02-28
IE44069L (en) 1977-02-27
CH624115A5 (ja) 1981-07-15
DE2538075A1 (de) 1977-03-17
FR2321888A1 (fr) 1977-03-25
AT350737B (de) 1979-06-11
SE7609495L (sv) 1977-02-28
ES454084A1 (es) 1977-11-16
BG27546A4 (en) 1979-11-12
BG27545A3 (en) 1979-11-12
AU499926B2 (en) 1979-05-03
AU1720176A (en) 1978-03-02
CS192599B2 (en) 1979-08-31
MX4133E (es) 1982-01-06
IL50355A0 (en) 1976-10-31
GB1519719A (en) 1978-08-02
NL7609485A (nl) 1977-03-01
CH624116A5 (ja) 1981-07-15
NO762932L (ja) 1977-03-01
BE845563A (fr) 1977-02-28
ES450897A1 (es) 1977-12-01
SU638262A3 (ru) 1978-12-15
DK143278C (da) 1981-12-07
US4100288A (en) 1978-07-11
HU176929B (hu) 1981-06-28
ES454085A1 (es) 1977-11-16
JPS5231100A (en) 1977-03-09
DD127145A5 (ja) 1977-09-07
ES454087A2 (es) 1977-11-16
GR61158B (en) 1978-09-30
CH622521A5 (ja) 1981-04-15
PL110724B1 (en) 1980-07-31
DK143278B (da) 1981-08-03
FR2321888B1 (ja) 1980-01-11
YU208176A (en) 1982-08-31
PT65521B (de) 1978-07-04
LU75667A1 (ja) 1977-09-13
PL192020A1 (pl) 1979-03-12
NO145793C (no) 1982-06-02
DK386876A (da) 1977-02-28
IE44069B1 (en) 1981-08-12
CA1068266A (en) 1979-12-18
CS192564B2 (en) 1979-08-31
PL109091B1 (en) 1980-05-31

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